CD5-negative chronic lymphocytic leukemia with indolent clinical course and autoimmune thrombocytopenia, successfully treated with rituximab

American Journal of Hematology

Volumn 77, Issue 4, 2004, Pages 413-415

  Okamoto, Masashi ^a   Nakano, Sonoko ^a   Namura, Kyoko ^a   Yamada, Noriko ^a   Uchida, Ryo ^a   Fuchida, Shin Ichi ^a   Okano, Akira ^a   Ochiai, Naoya ^a   Shimazaki, Chihiro ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Autoimmune thrombocytopenia; CD5 negative; Chronic lymphocytic leukemia; CLL; MLUS; Monoclonal B lymphocytosis of undetermined significance; Rituximab

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD23 ANTIGEN; CD5 ANTIGEN; CELL MARKER; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; PROTEIN SMIG; RITUXIMAB; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW BIOPSY; CASE REPORT; CELL MATURATION; CHRONIC LYMPHATIC LEUKEMIA; DISEASE ASSOCIATION; DISEASE COURSE; FLOW CYTOMETRY; HEPATOSPLENOMEGALY; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOSIS; MALE; PRIORITY JOURNAL; SYMPTOMATOLOGY; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD5; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; FLOW CYTOMETRY; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; TREATMENT OUTCOME;

EID: 9644253073     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20223     Document Type: Article

References (10)

1. Jaffe ES, Harris NL, Stein H, Vardiman JW. World Health Organization classification of tumors: pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer; 2001.
2. - small B-cell leukemias are rarely classifiable as chronic lymphocytic leukemia. Am J Clin Pathol 1999;111:123-130.
3. Wang C, Amato D, Fernandes B. CD5-negative phenotype of monoclonal B-lymphocytosis of undetermined significance (MLUS). Am J Hematol 2002;69:147-149.
4. Keung YK, Buss D, Pettenati M, Powell BL. CD5-negative chronic lymphocytic leukemia or monoclonal B-lymphocytosis of undetermined significance? Am J Hematol 2002;70:334.
5. Sheikh SS, Kallakury BV, Al-Kuraya KA, Meek J, Hartmann DP, Bagg A. CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity? Am J Hematol 2002;71:306-310.
6. Kimby E, Mellstedt H, Bjorkholm M, Holm G. Clonal cell surface structures related to differentiation, activation and homing in B-cell chronic lymphocytic leukemia and monoclonal lymphocytosis of undetermined significance. Eur J Haematol 1989;43:452-459.
7. + and CD5 B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004;103:2337-2342.
8. Dillman RO. Treatment of low-grade B-cell lymphoma with the monoclonal antibody rituximab. Semin Oncol 2003;30:434-447.
9. Robak T. Monoclonal antibodies in the treatment of autoimmune cytopenias. Eur J Haematol 2004;72:79-88.
10. Mavromatis B, Cheson BD. Monoclonal antibody therapy of chronic lymphocytic leukemia. J Clin Oncol 2003;21:1874-1881.