Nucleosome arrays reveal the two-start organization of the chromatin fiber

Science

Volumn 306, Issue 5701, 2004, Pages 1571-1573

  Dorigo, Benedetta ^a   Schalch, Thomas ^a   Kulangara, Alexandra ^a   Duda, Sylwia ^a   Schroeder, Rasmus R ^b   Richmond, Timothy J ^a  

^a ETH ZURICH   (Switzerland)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; DNA; FIBERS;

CHROMATIN FIBERS; GENE REGULATION;

GENES;

AMINO ACID; DISULFIDE; DNA; HISTONE;

GENE;

ARTICLE; CHROMATIN; CROSS LINKING; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; GENE; GENE CONTROL; GENOME; NUCLEOSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANIMALS; CHROMATIN; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTONES; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTATION; NUCLEOSOMES; PROTEIN FOLDING; XENOPUS LAEVIS;

CROSS LINKING; FIBERS; GENES; NUCLEIC ACIDS;

EUKARYOTA;

EID: 9444297879     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103124     Document Type: Article

References (23)

1. K. E. van Holde, Chromatin, Springer Series in Molecular Biology, A. Rich, Ed (Springer-Verlag, New York, 1988).
2. K. Luger, A. W. Maeder, R. K. Richmond, D. F. Sargent, T. J. Richmond, Nature 389, 251 (1997).
3. C. A. Davey, D. F. Sargent, K. Luger, A. W. Mäder, T. J. Richmond, J. Mol. Biol. 319, 1097 (2002).
4. T. J. Richmond, J. Widom, in Chromatin Structure and Gene Expression, S. C. R. Elgin, J. L. Workman, Eds. (Oxford Univ. Press, Oxford. 2000), pp. 1-23.
5. Y. O. Strukov, Y. Wang, A. S. Belmont, J. Cell Biol. 162, 23 (2003).
6. J. Widom, A. Klug, Cell 43, 207 (1985).
7. C. L. F. Woodcock, L.-L. Y. Frado, J. B. Rattner, J. Cell Biol. 99, 42 (1984).
8. J. T. Finch, A. Klug, Proc. Natl. Acad. Sci. U.S.A. 73. 1897 (1976).
9. F. Thoma, T. Koller, A. Klug, J. Cell Biol. 83, 403 (1979).
10. J. D. McGhee, J. M. Nickol, O. Felsenfeld, D. C. Rau, Cell 33, 831 (1983).
11. A. Worcel, S. Strogatz, D. Riley, Proc. Natl. Acad. Sci. U.S.A. 78, 1461 (1981).
12. S. P. Williams et al., Biophys. J. 49, 233 (1986).
13. B. Dorigo, T. Schalch, K. Bystricky, T. J. Richmond, J. Mol. Biol. 327, 85 (2003).
14. J. B. Rattner, B. A. Hamkalo, Chromosome 69, 363 (1978).
15. L. M. Carruthers, J. Bednar, C. L. Woodcock, J. C. Hansen, Biochemistry 37, 14776 (1998).
16. X. Shen, L. Yu, J. W. Weir, M. A. Gorovsky, Cell 82, 47 (1995).
17. H. G. Patterton, C. C. Landel, D. Landsman, C. L. Peterson, R. T. Simpson, J. Biol. Chem. 273, 7268 (1998).
18. J. L. Barra, L. Rhounim, J. L. Rossignol, G. Faugeron, Mol. Cell. Biol. 20, 61 (2000).
19. A. Ramon, M. I. Muro-Pastor, C. Scazzocchio, R. Gonzalez, Mol. Microbiol. 35, 223 (2000).
20. Y. Fan et al., Mol. Cell. Biol. 23, 4559 (2003).
21. J. Bednar, R. A. Horowitz, J. Dubochet, C. L. Woodcock, J. Cell Biol. 131, 1365 (1995).
22. B. Dorigo, T. J. Richmond, data not shown.
23. We thank M. Müller and H. Gross for assistance with EM and V. Ramakrishnan for providing the H1 expression plasmid. We are grateful for financial support from the Swiss National Science Foundation through the National Center for Competence in Research Structural Biology and a grant to T.J.R.