Circadian variations of biochemical variables in aspartame treated rats

Pharmaceutical Biology

Volumn 42, Issue 1, 2004, Pages 1-7

  Rajasekar, P ^a   Subramanian, P ^a   Manivasagam, T ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Aspartame; Biochemical variables; Circadian rhythms

Indexed keywords

ASPARTAME; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE;

ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN LEVEL; BRAIN NUCLEUS; BRAIN REGION; CHOLESTEROL BLOOD LEVEL; CIRCADIAN RHYTHM; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; MALE; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; OSCILLATION; PROTEIN BLOOD LEVEL; RETINOHYPOTHALAMIC TRACT; SUPRACHIASMATIC NUCLEUS;

ANIMALIA;

EID: 9444293994     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200390500885     Document Type: Article

References (41)

1. Abdollahi, Nikfar, Abdoli (2001): Potentiation by nitric oxide synthase inhibitor and calcium channel blocker of aspartame induced antinociception in the neouse formalin test. Blackwell Sci Funda Clin Pharmacol 15: 117-123.
2. Beck B, Urlet A, Pierre Man J, Krongrad A (2002): Effects of long-term ingestion of aspartame on hypothalamic neuropeptide Y, pasma leptin and body weight gain and composition. J Physiol Behav 75: 41-47.
3. Berezkin MV, Grastisinskii EN, Kudinova VF, Batygov AN, Ponomareve LE, Prikazchikova O, Zhunkova GN (1992): Seasonal and circadian fluctuactions in blood biochemical indicators in mice in natural conditions and exposed to constant light. Bull EKSP Biol Med 114: 75-78.
4. Burns TS, Stargel WW, Tsehanz C, Kotdonis FN, Hurwitz A (1991): Aspartame and sucrose produce a similar increase in the plasma phenylalanine to large neutal amino acid ratio in healthy subjects. Pharmacology 43: 210-219.
5. Caillol M, Devinoy E, Lacroise MC, Schirar A (2000): Endothelial and neuronal nitric oxide synthases are present in the suprachiasmatic nuclei of syrian hamsters and rats. Eur J Neurosci 12: 649-61.
6. Coll AR, Arderiux F, Noguera AD (1993): Circadian rhythms of serum concentrations of 12 enzymes of clinical interest. Chronobiol Int 10: 190-202.
7. Csaki A, Kocsis K, Halasz B, Kiss J (2000): Localization of glutamatergic/ aspartatergic neurons projecting to the hypothalamic paraventricular nucleus studied by retero grade transport. J Neurosci 101: 637-655.
8. Devries MJ, Meijer JH (1991): Aspartate injections into the suprachaismatic region of Syrian hamsters do not mimic the effects of light on the circadian activity rhythys. Neurosci Lett 127: 215-218.
9. Disk (2000): Micromedex international health series. Aspartame neurologic clinical effects. Toxicol Inf Poison: 105.
10. Fings CS, Toltiff CR, Duonin RT (1970): Glucose determination by o-toluidine method using glacial acetic acid. In: G Toro PG Ackermann eds., Practical Clinical Chemistry. Boston. Little Brown and Bronon CO 115-118.
11. Forster CH, Winter C, Hofbauer A, Hall JC, Stanewsky R (2001): The circadian clock of fruit flies is blind after elimination of all known photoreceptor. J Neuron 30: 249-261.
12. Goerss AL, Wagner GC, Wendy L (2000): Acute effects of aspartame on aggression and neurochemistry of rats. Life Sci 67: 1325-1329.
13. Hannibal J (2002): Neurtransmitters of the retinohypothalamic tract. J Cell Tissue Res 309: 73-88.
14. Honma S, Katsuno Y, hinohara K, Abe H, Honma K [1996]: Circadian rhythm and response to light of extracellular glutamate and aspartate in rat suprachiasmatic nucleus. Am J Physiol 271: [Regulatory Integrative Comp Physiol 40] R579-R585.
15. Jones PJH, Schoeller DA (1990): Evidence of diurnal periodicity in human cholesterol synthesis. J Lipid Res 37: 667-693.
16. 3H-GABA from the suprachiasmatic nucleus in slices of rat hypothalamus. Brain Res Bull 16: 527-531.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951): Protein measurement with the Folin-phenol reagent. J Biol Chem 193: 265-275.
18. Meller ST, Gebhart GF (1993): Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 2: 127-136.
19. Mietencen TA (1982): Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. J Lipid Res 23: 466-473.
20. Mintz EM, Marvel CL, Gillespie CF, Price KM, Albers HE (1999): Activation of NMDA receptors in the suprachiasmatic nucleus produces light-like phase shifts of the circadian clock in vivo. J Neurosci 19: 5124-5130.
21. Moller SE (1991): Effect of aspartame and protein administered in phenylalanine equivalence doses, on plasma netural amino acids, aspartate, insulin, and glucose in man. Pharmacol Toxicol 68: 408-412.
22. Nguyen UN, Dumoulin G, Henriet MT, Reganrd J (1998): Aspartame ingestion increases urinary calcium, but not oxalate excretion, in healthy subjects. Clin Endocrinol Metabol 83: 165-168.
23. Pappu AS, Illingworth DR (1994): Diurnal variations in the plasma concentrations of mevalonicacid in patients with abeta lipoproteinaemia. Eur J Clin Invest 24: 698-702.
24. Pfleiderer G (1969): In: Methods of Enzymatic Analysis. Bergmeyer HU Ed, New York and London, Academic Press, pp. 381-383.
25. Rajakrishnan V, Subramanian P, Viswanathan P, Menon VP (1999): Effect of chronic ethanol ingestion on biochemical circadian rhythms in Wistar rats. Alcohol 18: 147-152.
26. Ranney RE, Oppermann JA (1979): A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man. J Environ Pathol Toxicol 2: 979-985.
27. Reitman S, Frankel AS (1957): A colorimetric method for the determination of serum glutamic, oxaloacetic and glutamic pyruvic transaminases. Am J Clin Path 28: 53-56.
28. Sharma KP, Coulombe RA (1987): Effects of intense sweeteners on hunger, food intake and body weight. Food Chem Toxicol 25: 565-568.
29. Smith RQ (2000): Transport of glutamate and other aminoacids at the blood brain barrier. J Nutr 30: 1016S-1022S.
30. Subramanian P, Balamurugan E (1999): Temporal oscillations of serum electrolytes in N-phathaloyl GABA-treated rats. Pharmacol Biochem Behav 62: 551-514.
31. Subramanian P, Menon VP, Arokiam FV, Rajakrishnan V (1998): Lithium modulates biochemical circadian rhythms in Wistar rats. Chronobiol Int 15: 29-38.
32. Subramanian P, Sivabalan S, Menon VP, Vasudevan K (2000) Influence of chronic zinc supplementation on biochemical variables and circadian rhythms in Wistar rats. J Nutr Res 20: 413-425.
33. Subramanian P, Sunderasen S, Balamurugan E (2001): Temporal oscillations of phosphatases in N-phthaloyl gamma-aminobutyric acid treated rats. Indian J Exptl Biol 36: 1141-1143.
34. Takeuchi Y, Takahashi K (1994): Circadian variations of amino acid content of suprachiasmatic nucleus in rats. Neuroscience Lett 178: 275-278.
35. Torie K, Mimura T, Takasaki Y, Ichimura M (1985): Dietary aspartame with protein on plasma and brain amino acids, brain monoamines and behaviour in rats. J Physiol Behav 36: 765-771.
36. Touitou Y, Rein berg A, Bogdan A, Auzeby A, Beck H, Touitou C (1986): Differences between young and elderly subjects in variations of total plasma proteins and blood volume as reflected by hemoglobin, hematocrit and erythrocyte counts. Clin Chem 32: 801-804.
37. Ueberberg H, Laque K, Trieb G (1984): Comparative studies on the circadian rhythm of conticosterone lipid and cholesterol levels in adrenals and blood of rats. Chronobiol Int 1: 41-49.
38. Vandenpol AN (1980): The hypothalamic suprachiasmatic nucleus of the rat intrinsic anatomy. J Comp Neurol 191: 661-702.
39. Yagub A, Eldred WD (1991): Localization of aspartate like immuno reactivity in the retina of the turtle (Pseudemys scripta). J Comp Neurol 312: 584-598.
40. Yokogoshi H, Roberts CH, Caballero B, Wurtman RJ (1984): Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxy indoles. Am J Clin Nutr 40: 1-7.
41. Zlatkis A, Zak B, Boyle AJ (1953): A new method for the direct determination of serum cholesterol. J Lab Clin Med 45: 486.