Identity and regulation of stored and secreted progastrin-derived peptides in sheep

Endocrinology

Volumn 145, Issue 11, 2004, Pages 5129-5140

  Paterson, Adrienne C ^a   Lockhart, Sharon M ^a   Baker, Josephine ^a   Neumann, Greg ^a   Baldwin, Graham S ^a   Shulkes, Arthur ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN; HYDROCHLORIC ACID; OMEPRAZOLE; PEPTIDE; PROGASTRIN; PROTON PUMP INHIBITOR; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SHEEP; STOMACH ANTRUM; STOMACH PH;

ANESTHESIA; ANIMALS; ANTI-ULCER AGENTS; CHROMATOGRAPHY; CONSCIOUSNESS; GASTRINS; MASS SPECTROMETRY; OMEPRAZOLE; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; PYLORIC ANTRUM; SHEEP; SOMATOSTATIN;

EID: 9244264383     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0912     Document Type: Article

References (52)

1. Mersey SJ, Sachs G 1995 Gastric acid secretion. Physiol Rev 75:155-189
2. Walsh JH 1994 Gastrin. In: Walsh JH, Dockray GJ, eds. Gut peptides. New York: Raven Press; 75-122
3. Dockray GJ, Varro A, Dimaline R 1996 Gastric endocrine cells: gene expression, processing, and targeting of active products. Physiol Rev 76:767-798
4. Rehfeld JF 1998 The new biology of gastrointestinal hormones. Physiol Rev 78:1087-1108
5. Baldwin GS, Shulkes A 1998 Gastrin, gastrin receptors and colorectal carcinoma. Gut 42:581-584
6. Dockray GJ, Varro A, Dimaline R, Wang T 2001 The gastrins: their production and biological activities. Annu Rev Physiol 63:119-139
7. Iwase K, Evers BM, Hellmich MR, Guo Y, Higashide S, Kim HJ, Townsend CMJ 1997 Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 113:782-790
8. Koh TJ, Chen D 2000 Gastrin as a growth factor in the gastrointestinal tract. Regul Pept 93:37-44
9. Chen D, Zhao CM, Dockray GJ, Varro A, Van Hoek A, Sinclair NF, Wang TC, Koh TJ 2000 Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice. Gastroenterology 119:756-765
10. Dickinson CJ, Marino L, Yamada T 1990 Inhibition of the a amidation of gastrin; effects on gastric acid secretion. Am J Physiol 258:G810-G814
11. Palnaes Hansen C, Stadil F, Rehfeld JF 1996 Metabolism and influence of glycine-extended gastrin on gastric acid secretion in man. Digestion 57:22-29
12. Higashide S, Gomez G, Greeley Jr GH, Townsend Jr CM, Thompson JC 1996 Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats. Am J Physiol 270:G220-G224
13. Desmond H, Varro A, Young J, Gregory H, Nemeth J, Dockray GJ 1989 The constitution and properties of phosphorylated and unphosphorylated C-terminal fragments of progastrin from dog and ferret antrum. Regul Pept 25:223-233
14. Sandvik AK, Dockray GJ 1999 Biological activity of carboxy-terminal gastrin analogs. Eur J Pharmacol 364:199-203
15. Wang TC, Koh TJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Dockray GJ 1996 Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 98:1918-1929
16. Koh TJ, Dockray GJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Wang TC 1999 Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 103:1119-1126
17. Baldwin GS, Hollande F, Yang Z, Karelina Y, Paterson A, Strang R, Fourmy D, Neumann G, Shulkes A 2001 Biologically active recombinant human progastrin(6-80) contains a tightly bound calcium ion. J Biol Chem 276:7791-7796
18. Singh P, Lu X, Cobb S, Miller BT, Tarasova N, Varro A, Owlia A 2003 Progastrinl-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites. Am J Physiol 284:G328-G339
19. Rehfeld JF, van Solinge WW 1994 The tumor biology of gastrin and cholecystokinin. Adv Cancer Res 63:295-347
20. Ciccotosto GD, McLeish A, Hardy KJ, Shulkes A 1995 Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 109:1142-1153
21. Van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer UG, Rehfeld JF 1993 Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 104:1099-1107
22. Nemeth J, Taylor B, Pauwels S, Varro A, Dockray GJ 1993 Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 34:90-95
23. Del Valle J, Sugano K, Yamada T 1987 Progastrin and its glycine-extended posttranslational processing intermediates in human gastrointestinal tissues. Gastroenterology 92:1908-1912
24. Jensen S, Borch K, Hilsted L, Rehfeld JF 1989 Progastrin processing during antral G-cell hypersecretion in humans. Gastroenterology 96:1063-1070
25. Desmond H, Dockray GJ, Spurdens M 1985 Identification by specific radioimmunoassay of two novel peptides derived from the C-terminus of porcine preprogastrin. Regul Pept 11:133-142
26. Pauwels S, Desmond H, Dimaline R, Dockray GJ 1986 Identification of progastrin in gasrrinomas, antrum, and duodenum by a novel radioimmunoassay. J Clin Invest 77:376-381
27. Varro A, Desmond H, Pauwels S, Gregory H, Young J, Dockray GJ 1988 The human gastrin precursor. Characterization of phosphorylated forms and fragments. Biochem J 256:951-957
28. Varro A, Nemeth J, Bridson J, Lee C, Moore S, Dockray GJ 1990 Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products. J Biol Chem 265:21476-21481
29. Azuma T, Taggart RT, Walsh JH 1987 Effects of bombesin on the release of glycine-extended progastrin (gastrin G) in rat antral tissue culture. Gastroenterology 93:322-329
30. Sugano K, Park J, Dobbins WO, Yamada T 1987 Glycine-extended progastrin processing intermediates: accumulation and cosecretion with gastrin. Am J Physiol G502-G507
31. Hilsted L, Hansen CP 1988 Corelease of amidated and glycine-extended antral gastrins after a meal. Am J Physiol 255:G665-G669
32. Ciccotosto GD, Shulkes A 1992 Pharmacokinetics and organ specific metabolism of glycine-extended and amidated gastrin in sheep. Am J Physiol 263:G802-G809
33. Rahier J, Pauwels S, Dockray GJ 1987 Biosynthesis of gastrin. Localization of the precursor and peptide products using electron microscopic-immunogold methods. Gastroenterology 92:1146-1152
34. Dockray GJ 1999 Topical review. Gastrin and gastric epithelial physiology. J Physiol 518:315-324
35. Paterson AC, Baldwin GS, Shulkes A 2002 Metabolism of recombinant progastrin in sheep. Am J Physiol 283:E449-E456
36. Zavros Y, Fleming WR, Hardy KJ, Shulkes A 1998 Regulation of fundic and antral somatostatin secretion by CCK and gastrin. Am J Physiol 274:G742-G750
37. Moore C, Jie R, Shulkes A, Baldwin GS 1997 Molecular cloning and sequence of the ovine gastrin gene. DNA Seq 8:39-44
38. Shulkes A, Read M 1991 Regulation of somatostatin secretion by gastrin- and acid-dependent mechanisms. Endocrinology 129:2329-2334
39. +-ATPaSe and carbonic anhydrase in the sheep. Regul Pept 40:13-27
40. Varro A, Nemeth J, Bridson J, Lonovics J, Dockray GJ 1990 Modulation of posttranslational processing of gastrin precursor in dogs. Am J Physiol 258:G904-G909
41. Bundgaard JR, Birkedal H, Rehfeld JF 2004 Progastrin is directed to the regulated secretory pathway by synergistically acting basic and acidic motifs. J Biol Chem 279:5488-5493
42. 17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. Int J Cancer 94:307-313
43. Singh P, Velasco M, Given R, Varro A, Wang TC 2000 Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 119:162-171
44. Eng J, Gubler U, Raufman JP, Chang M, Mulmes JD, Pan YC, Yalow RS 1986 Cholecystokinin-associated COOH-terminal peptides are fully sulfated in pig brain. Proc Natl Acad Sci USA 83:2832-2835
45. Varro A, Young J, Gregory H, Cseh J, Dockray GJ 1986 Isolation, structure and properties of the C-terminal flanking peptide of preprocholecystokinin from rat brain. FEBS Lett 204:386-390
46. Adrian TE, Domin J, Bacarese-Hamilton AJ, Bloom SR 1986 Is the C-terminal flanking peptide of rat cholecystokinin double sulphated? FEBS Lett 196:5-8
47. Dockray GJ, Varro A, Desmond H, Young J, Gregory H, Gregory RA 1987 Post-translational processing of the porcine gastrin precursor by phosphorylation of the COOH-terminal fragment. J Biol Chem 262:8643-8647
48. Power DM, Dimaline R, Balaspiri L, Dockray GJ 1988 A novel gastrin-processing pathway in mammalian antrum. Biochim Biophys Acta 954:141-147
49. Kothary PC, Mahoney WC, Vinik AI 1987 Identification of gastrin molecular variants in gastrinoma syndrome. Regul Pept 17:71-84
50. Shulkes A, Hardy KJ 1982 Effect of somatostatin on basal concentrations of gastrin and pancreatic polypeptide in the fetal sheep. Biol Neonate 42:249-256
51. +-ATPase a-subunit gene expression through a novel receptor. J Biol Chem 270:11155-11160
52. Fox JG, Rogers AB, Ihrig M, Taylor NS, Whary MT, Dockray G, Varro A, Wang TC 2003 Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res 63:942-950