Inhibitory properties of the anti-bothropic complex from Didelphis albiventris serum on toxic and pharmacological actions of metalloproteases and myotoxins from Bothrops asper venom

Biochemical Pharmacology

Volumn 62, Issue 11, 2001, Pages 1521-1529

  Trento, Edilson P ^a   Garcia, Omar S ^a   Rucavado, Alexandra ^b   França, Suzelei C ^c   Batalini, Claudemir ^a   Arantes, Eliane C ^d   Giglio, José R ^d   Soares, Andreimar M ^b,c,d  

^a UNIC   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anti bothropic complex; Anti ophidian activity; Bothrops asper; Didelphis albiventris; Metalloproteases; Myotoxic phospholipases A2; Snake venom

Indexed keywords

ANTI BOTHROPIC COMPLEX; ARGININE; CASEIN; FIBRIN; FIBRINOGEN; METALLOPROTEINASE; MYOTOXIN; PHOSPHOLIPASE A2; PROLINE; PROTEIN; PROTEIN BAH; PROTEIN BAP1; PROTEIN SUBUNIT; SEPHAROSE; TOXIN; UNCLASSIFIED DRUG; VENOM;

AFFINITY CHROMATOGRAPHY; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BLEEDING; BOTHROPS ASPER; CONTROLLED STUDY; DIDELPHIS ALBIVENTRIS; EDEMA; ENZYME ACTIVITY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; ISOELECTRIC POINT; MALE; MARSUPIAL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN ISOLATION; SEQUENCE HOMOLOGY; SNAKE;

AMINO ACIDS; ANIMALS; BLOOD PROTEINS; BOTHROPS; CARRIER PROTEINS; CROTALID VENOMS; HEMORRHAGE; METALLOENDOPEPTIDASES; NEUROTOXINS; OPOSSUMS; PHOSPHOLIPASES A; SEQUENCE ANALYSIS, PROTEIN;

EID: 0035581335     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00800-0     Document Type: Article

References (42)

1. Structure, function and biophysical aspects of the myotoxins from snake venoms
2. 2 myotoxins from Bothrops snake venoms
3. Hemorrhagic metalloproteinases from snake venoms
4. Snake venom proteases affecting hemostasis and thrombosis
5. Clinical toxicology of snakebite in Central America
6. Pathological changes induced by BaH1, a hemorrhagic metalloproteinase isolated from Bothrops asper (terciopelo) snake venom, on mouse capillary blood vessels
7. Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper
8. Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)
9. Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
10. Clinical toxicology of snakebite in Africa and the Middle East/Arabian Peninsula
11. Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom
12. Natural anti-snake venom proteins
13. Snake envenomation and protective natural endogenous proteins: A mini review of the recent developments (1991-1997)
14. Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine
15. Isolation and partial characterization of an anti-bothropic complex from the serum of South American Didelphidae
16. Inhibitory properties of the antibothropic complex from the South American opossum (Didelphis marsupialis) serum
17. Isolation and characterization of DM40 and DM43, two snake venom metalloproteinase inhibitors from Didelphis marsupialis serum
18. Isolation of protein factors from opossum (Didelphis albiventris) serum which protect against Bothrops jararaca venom
19. 2 from Bothrops venoms by the heteromeric protein complex of Didelphis albiventris opossum serum
20. Release of sarcoplasmic enzymes from skeletal muscle by Bothrops jararacussu venom: Antagonism by heparin and the serum of South American marsupials
21. Factors underlying the natural resistance of animals against snake venoms
22. Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum
23. Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum
24. 2 myotoxins from Bothrops snake venoms
25. A micro-biuret method for estimating proteins
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Isoelectric focusing of proteins in polyacrylamide gels
28. Rapid analysis of amino acids using pre-column derivatization
29. Studies on the quantitative method for determination of hemorrhagic activity of habu snake venom
30. Structural and functional characterization of neuwiedase, a nonhemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom
31. Structural and functional characterization of a myotoxin I from Bothrops moojeni (caissaca) snake venom
32. 2 homologue, from Bothrops neuwiedi pauloensis venom
33. Purification and properties of phospholipase A from porcine pancreas
34. Isolation from opossum serum of a metalloproteinase inhibitor homologous to human α1 B-glycoprotein
35. A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tesselata: Isolation, characterization and mechanism of neutralization
36. Molecular structure and mechanism of action of the crotoxin inhibitor from Crotalus durissus terrificus serum
37. 2 inhibitor from the plasma of Thailand cobra having structural similarity to urokinase-type plasminogen activator receptor and LY-6 related proteins
38. 2 myotoxin inhibitor from the plasma of the snake Bothrops asper
39. 2 myotoxins from its own venom: Isolation, molecular cloning and biological properties
40. Primary structure of the antihemorrhagic factor in serum of the Japanese Habu: A snake venom metalloproteinase inhibitor with double-headed cystatin domain
41. 2