Mitochondrial membrane potential and nucleosidic inhibitors of HIV reverse transcriptase: A cytometric approach

Mitochondrion

Volumn 4, Issue 2-3, 2004, Pages 271-278

  Ferraresi, Roberta ^a   Troiano, Leonarda ^a   Rossi, Daniela ^a   Gualdi, Elena ^a   Lugli, Enrico ^a   Mussini, Cristina ^b   Cossarizza, Andrea ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Flow cytometry; HAART; Mitochondria

Indexed keywords

ANTIVIRUS AGENT; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

ARTICLE; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG SENSITIVITY; FLOW CYTOMETRY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TOXICITY; PRIORITY JOURNAL;

EID: 9244223649     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2004.05.015     Document Type: Article

References (38)

1. R.P. Agarwal O.A. Olivero Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3′-azido-2′,3′-dideoxythymidine Mutat. Res. 390 1997 223-231
2. E. Arnaudo M. Dalakas S. Shanske C.T. Moraes S. DiMauro E.A. Schon Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy Lancet 337 1991 508-510
3. D. Barbieri L. Troiano E. Grasselli C. Agnesini E.A. Cristofalo D. Monti et al. Inhibition of apoptosis by zinc, a reappraisal Biochem. Biophys. Res. Commun. 187 1992 2156-2161
4. M. Barile D. Valenti G.A. Hobbs M.F. Abruzzese S.A. Keilbaugh S. Passarella et al. Mechanisms of toxicity of 3′-azido-3′-deoxythymidine. Its interaction with adenylate kinase Biochem. Pharmacol. 48 1994 1405-1412
5. M. Barile D. Valenti S. Passarella E. Quagliariello 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator Biochem. Pharmacol. 53 1997 913-920
6. K. Brinkman J.A. Smeitink J.A. Romijn P. Reiss Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy Lancet 354 1999 1112-1115
7. A. Carr K. Samaras D.J. Chisholm D.A. Cooper Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance Lancet 351 1883 1881-1883
8. C.L. Cherry M.E. Gahan J.C. McArthur S.R. Lewin J.F. Hoy S.L. Wesselingh Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat J. AIDS 30 2002 271-277
9. A. Cossarizza Tests for mitochondrial function and DNA, potentials and pitfalls Curr. Opin. Infect. Dis. 16 2003 5-10
10. A. Cossarizza G. Moyle Antiretroviral nucleoside and nucleotide analogues and the mitochondria (Editorial Review) AIDS 18 2004 137-151
11. A. Cossarizza S. Salvioli Flow cytometrical analysis of mitochondrial membrane potential In: J.P. Robinson Z. Darzynkiewicz P. Dean L.G. Dressler P. Rabinovitch C. Stewart H. Tanke L. Wheeless (Eds.) Current Protocols in Cytometry 2000 Wiley New York, NY, USA 9.14.1-9.14.7
12. A. Cossarizza M. Baccarani Contri G. Kalashnikova C. Franceschi A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation
13. A. Cossarizza C. Mussini A. Viganò Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs, actors or bystanders? BioEssays 23 2001 1070-1080
14. A. Cossarizza M. Pinti L. Moretti D. Bricalli R. Bianchi L. Troiano et al. Mitochondrial functionality and mitochondrial DNA content in lymphocytes of vertically-infected HIV+children with HAART-related lipodystrophy J. Infect. Dis. 185 2002 299-305
15. A. Cossarizza A. Riva M. Pinti S. Ammannato P. Fedeli C. Mussini et al. Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy Antiviral Ther. 8 2003 51-57
16. H.C. Côté B. Yip J.J. Asselin J.W. Chan R.S. Hogg P.R. Harrigan et al. Mitochondrial:nUclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens J. Infect. Dis. 187 1976 1972-1972
17. H.C.F. Côté Z.L. Brumme K.J.P. Craib C.S. Alexander B. Wynhoven L. Ting et al. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients New Engl. J. Med. 346 2002 811-820
18. M.C. Dalakas C. Semino-Mora M. Leon-Monzon Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2′3′-dideoxycytidine (ddC) Lab. Invest. 81 2001 1537-1544
19. A. Foli F. Benvenuto G. Piccinini A. Bareggi A. Cossarizza J. Lisziewicz et al. Direct analysis of mitochondrial toxicity of antiretroviral drugs AIDS 15 2001 1687-1694
20. P. Lestienne Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro Biochem. Biophys. Res. Commun. 146 1987 1146-1153
21. S. Lopez O. Mirò E. Martinez E. Pedrol B. Rodriguez-Santiago A. Milinkovic et al. Mitochondrial effects of antiretroviral therapies in asymptomatic patients Antiviral Ther. 9 2004 47-55
22. G. McComsey D.J. Tan M. Lederman E. Wilson L.J. Wong Analysis of mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with of without lipoatrophy AIDS 16 2002 513-518
23. O. Mirò M. Gomez E. Pedrol F. Cardellach V. Nunes J. Casademont Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy AIDS 14 2000 1855-1857
24. O. Mirò S. Lopez E. Pedrol B. Rodriguez-Santiago E. Martinez A. Soler et al. Mitochondrial DNA depletion and respiratory chain enzyme deficiencies are present in peripheral blood mononuclear cells of HIV-infected patients with HAART-related lipodystrophy Antiviral Ther. 8 2003 333-338
25. J.S. Montaner H.C. Côté M. Harris R.S. Hogg B. Yip J.W. Chan et al. Mitochondrial toxicity in the era of HAART, evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy J. AIDS Suppl 1 2003 S85-S90
26. X.R. Pan-Zhou L. Cui X.J. Zhou J.P. Sommadossi V.M. Darley-Usmar Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells Antimicrob. Agents Chemother. 44 2000 496-503
27. M. Pinti L. Troiano M. Nasi R. Ferraresi J. Dobrucki A. Cossarizza Hepatoma HepG2 cells as a model for in vitro studies on mitochondrial toxicity of antiviral drugs, which correlation with the patient? J. Biol. Regulat. Homeost. Agents 17 2003 166-171
28. R. Polo S. Martinez P. Madrigal M. Gonzalez-Munoz Factors associated with mitochondrial dysfunction in circulating peripheral blood lymphocytes from HIV-infected people J. AIDS 34 2003 32-36
29. M. Reers T.W. Smith L.B. Chen J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential Biochemistry 30 1991 4480-4486
30. S. Safrin C. Grunfeld Fat distribution and metabolic changes in patients with HIV infection AIDS 13 1999 2493-2505
31. S. Salvioli G. Storci M. Pinti D. Quaglino L. Moretti M. Merlo-Pich et al. Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stress-induced proteins that impact on redux status and mitochondrial metabolism Cell Death Differ. 10 2003 163-174
32. C.M. Shikuma N. Hu F. Yost C. Waslien S. Shimizu B. Shiramizu Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy AIDS 15 2001 1801-1809
33. B. Shiramizu K.M. Shikuma L. Kamemoto M. Gerschenson G. Erdem M. Pinti et al. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving HAART during pregnancy J. AIDS 32 2003 370-374
34. S.T. Smiley M. Reers C. Mottola-Hartshorn M. Lin A. Chen T.W. Smith et al. Intracellular heterogeneity in mitochondrial membrane potential revealed by a J-aggregate-forming lipophilic cation JC-1 Proc. Natl Acad. Sci. USA 88 1991 3671-3675
35. D. Valenti M. Barile S. Passarella AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria Int. J. Mol. Med. 6 2000 93-96
36. C. Vigouroux S. Gharakhanian Y. Salhi T.H. Nguyen N. Adda W. Rozenbaum et al. Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease Diabetes Metab. 25 1999 383-392
37. U.A. Walker B. Setzer N. Venhoff Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors AIDS 16 2002 2165-2173
38. M.G. Zaera O. Mirò E. Pedrol A. Soler M. Picon F. Cardellach J. Casademont V. Nunes Mitochondrial involvement in antiretroviral therapy-related lipodystrophy AIDS 15 2001 1643-1651