HIV Type 1 Antigen-Responsive CD4+ T-Lymphocytes in Exposed Yet HIV Type 1 Seronegative Ugandans

AIDS Research and Human Retroviruses

Volumn 20, Issue 1, 2004, Pages 67-75

  Kebba, Anthony ^a   Kaleebu, Pontiano ^a   Serwanga, Jennifer ^a   Rowland, Samantha ^b   Yirrell, David ^a,c   Downing, Robert ^d   Gilmour, Jill ^b   Imami, Nesrina ^b   Gotch, Frances ^b   Whitworth, Jimmy ^a  

^a UVRI   (Uganda)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d Centers Dis Contr Prev Uganda   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON;

ADULT; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EVALUATION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOASSAY; MALE; PRIORITY JOURNAL; SEXUAL INTERCOURSE; T LYMPHOCYTE; UGANDA; VIRUS LOAD; VIRUS REPLICATION;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV ANTIGENS; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HIV-1; HUMANS; INTERFERON TYPE II; MALE; SPOUSES; UGANDA; VIRAL LOAD;

EID: 9144257814     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922204322749512     Document Type: Article

References (37)

1. Byrne JA and Oldstone M: Biology of cloned cytotoxic T lymphocytes specific for lymphochoriomeningitis virus: Clearance of virus in vivo. J Virol 1984;51:682-686.
2. + cytotoxic T-lymphocyte activity associated with control of viraemia in primary human immunodeficiency virus type 1 infection. J Virol 1994;68:6103-6110.
3. Yang OO, Kalams S, Rosenzweig M, et al.: Efficient lyses of human immunodeficiency virus type-1-infected cells by cytotoxic T lymphocytes. J Virol 1996;70:5799-5806.
4. Levy, JA: HIV pathogenesis and long-term survival. AIDS 1993; 7:1401-1418.
5. + lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J Clin Invest 2001;107:1303-1310.
6. Sriwanthana B, Hodge T, Mastro TD, et al.: HIV-specific cytotoxic T lymphocytes, HLA-A11 and chemokine related factors may act synergistically to determine HIV resistance in CCR5 (32 negative female sex workers in Chiang Rai, northern Thailand). AIDS Res Hum Retroviruses 2001;17:719-734.
7. Fowke KR, Kaul R, Rosenthal KL, et al.: HIV-1-specific cellular immune responses among HIV-1-resistant sex workers. Immunol Cell Biol 2000;78:586-595.
8. Mazzoli S, Trabattoni D, Caputo SL, et al.: HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nat Med 1997;3:1250-1257.
9. Rowland SJ, Dong T, Fowke KR, et al.: Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J Clin Invest 1998;102:1758-1765.
10. Beyrer C, Artenstein AW, Rugpao S, et al.: Epidemiologic and biologic characterisation of a cohort of human immunodeficiency virus type 1 highly exposed, persistently sero-negative female sex workers in northern Thailand. Chiang Mai HEPS Working Group. J Infect Dis 1999;179:59-67.
11. Bernard N, Yannakis C, Lee J, and Tsoukas C: Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed sero-negative persons. J Infect Dis 1999;179: 538-547.
12. Goh W, Markee J, Akridge RE, et al.: Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 co-receptor defects. J Infect Dis 1999;179:548-557.
13. Bienzele D, MacDonald K, Smaill F, et al.: Factors contributing to the lack of human immunodeficiency virus type 1 (HIV-1) transmission in HIV-1-discordant partners. J Infect Dis 2000;182: 123-132.
14. Kaul R, Plummer FA, Kamani J, et al.: HIV-1-specific mucosal cytotoxic T lymphocyte responses in the cervix of HIV-1 resistant prostitutes in Nairobi. J Immunol 2000;164:1602-1609.
15. Skurnick JH, Palumbo P, DeVico A, et al.: Correlates of non-transmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis 2002;185:428-438.
16. + T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease. J Infect Dis 2000;182:792-798.
17. Rosenberg ES and Walker BD: HIV type 1-specific helper T cells: A critical host defence. AIDS Res Hum Retroviruses 1998;14: 143-147.
18. Rosenberg ES, Billingsley JM, Caliendo AM, et al.: Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 1997;278:1447-1450.
19. Rosenberg S, Altfield M, Poon SH, et al.: Immune control of HIV-1 after early treatment of acute infection. Nature 2000;407: 523-526.
20. Malhotra U, Berrey M, Huang Y, et al.: Effect of combination antiretroviral therapy on T cell immunity in acute human immunodeficiency virus type 1 infection. J Infect Dis 2000;181:121-131.
21. Choi D, Dube S, Spicer TP, Slade HB, Jensen FC, and Poiesz BJ: HIV type 1 isolate Z321, the strain used to make a therapeutic HIV type 1 immunogen, is inter-subtype recombinant. AIDS Res Human Retroviruses 1997;13:357-361.
22. Hu DJ, Baggs J, Downing RG, et al.: Predominance of HIV-1 subtype A and D infections in Uganda. Emerg Infect Dis 2000; 6:609-615.
23. Moss RB, Wallace MR, Giermakowska WK, et al.: Phenotypic analysis of human immunodeficiency virus (HIV) type 1 cell mediated immune responses after treatment with an HIV-1 immunogen. J Infect Dis 1999;180:641-648.
24. Churdboonchart V, Sakondhavat C, Kulpradist S, et al.: A double blind, adjuvant controlled trial of human immunodeficiency virus type 1 (HIV-1) immunogen (Remune) monotherapy in asymptomatic, HIV-1-infected Thai subjects with CD4-cell counts of >300. Clin Diagn Immunol 2000;7:728-733.
25. Kuiken CL, Foley B, Hahn BH, et al.: Human Retroviruses and AIDS 1999: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Theoretical Biology and Biophysics Group. Los Alamos National Laboratory, Los Alamos, NM, 1999.
26. Kaleebu P, Whitworth J, Hamilton L, et al.: Molecular epidemiology of HIV type 1 in a rural community in Southwest Uganda. AIDS Res Hum Retroviruses 2000;16:393-401.
27. Yirrell DL, Pickering H, Palmarini G, et al.: Molecular epidemiological analysis of HIV in sexual networks in Uganda. AIDS 1998;12:285-290.
28. Van de Peer Y and De Wachter R: TREECON for Windows: A software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment. Comput Appl BioSci 1994;10:569-570.
29. Kimura M: A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 1980;16:111-120.
30. + T cell frequencies by flow cytometry: Evidence for a novel, antigen specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997;99:1739-1750.
31. Yirrell DL, Kaleebu P, Morgan D, et al.: Inter-and intra-genic inter-subtype HIV-1 recombination in rural and semi-urban Uganda. AIDS 2002;16:279-286.
32. Hart CE, Lennox JL, Pratt-Palmore M, et al.: Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tract. J Infect Dis 1999;179:871-872.
33. Reichelderfer PS, Coombs RW, Wright DJ, et al.: Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract: WHS study team. AIDS 2000;14:2101-2107.
34. Money DM, Arikan YY, Remple V, et al.: Genital tract and plasma immunodeficiency virus viral load throughout the menstrual cycle in women who are infected with ovulatory human immunodeficiency virus. Am J Obstet Gynecol 2003;188:122-128.
35. Parish CR: The relationship between cell mediated and humoral immunity. Transpl Rev 1972;13:35-66.
36. + T cell interactions are required for the primary generation of Th2 than Th1 cells. Eur J Immunol 2001;31:1765-1771.
37. Menon J and Bretscher P: Parasite dose determines the Th1/Th2 nature of the response to Leishmania major independently of infection route and strain of host or of parasite. Eur J Immunol 1998; 28:4020-4028.