Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders

Biological Psychiatry

Volumn 55, Issue 1, 2004, Pages 40-45

  Horiuchi, Yasue ^a   Nakayama, Junko ^a   Ishiguro, Hiroki ^a   Ohtsuki, Tsuyuka ^a   Detera Wadleigh, Sevilla D ^b   Toyota, Tomoko ^c   Yamada, Kazuo ^c   Nankai, Masahiro ^d   Shibuya, Haruo ^e   Yoshikawa, Takeo ^c   Arinami, Tadao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d TOKYO METROPOLITAN POLICE HOSPITAL   (Japan)

^e National Hospital Organization Hanamaki Hospital   (Japan)

Author keywords

Association; GABRA1; Genetics; Mood disorder; Transmission disequilibrium test

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA 1; UNCLASSIFIED DRUG;

ADULT; ALPHA CHAIN; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; EVALUATION; FEMALE; GENE MUTATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MOOD DISORDER; PEDIGREE; PRIORITY JOURNAL; SCREENING;

EID: 9144254111     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00689-9     Document Type: Article

References (19)

1. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics. 11:1955;375-386.
2. Barrueto F. Jr, Su M., Nelson L.S. Valproic acid is a structural analog of GABA that enters various metabolic pathways and has many clinical effects. J Emerg Med. 23:2002;303-304.
3. Coon H., Hicks A.A., Bailey M.E., Hoff M., Holik J., Harvey R.J., et al. Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatr Genet. 4:1994;185-191. ; discussion: 304-305.
4. Cossette P., Liu L., Brisebois K., Dong H., Lortie A., Vanasse M., et al. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nat Genet. 31:2002;184-189.
5. Devlin B., Roeder K. Genomic control for association studies. Biometrics. 55:1999;997-1004.
6. Dudbridge F., Koeleman B.P., Todd J.A., Clayton D.G. Unbiased applica-tion of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet. 66:2000;2009-2012.
7. Fawcett J. Valproate use in acute mania and bipolar disorder An international perspective . J Clin Psychiatry. 50:(suppl):1989;10-12.
8. Johnson K.J., Sander T., Hicks A.A., van Marle A., Janz D., Mullan M.J., et al. Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics. 14:1992;745-748.
9. Moss S.J., Smart T.G. Constructing inhibitory synapses. Nat Rev Neurosci. 2:2001;240-250.
10. Mukhopadhyay N., Almasy L., Schroeder M., Mulvihill W.P., Weeks D.E. Mega2, a data-handling program for facilitating genetic linkage and association analyses. Am J Hum Genet. 65:1999;A436.
11. Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees A preliminary report . Am J Med Genet. 74:1997;227-237.
12. Petty F., Trivedi M.H., Fulton M., Rush A.J. Benzodiazepines as antidepressants Does GABA play a role in depression? Biol Psychiatry. 38:1995;578-591.
13. Rice J.P., Goate A., Williams J.T., Bierut L., Dorr D., Wu W., et al. Initial genome scan of the NIMH genetics initiative bipolar pedigrees Chromosomes 1, 6, 8, 10, and 12 . Am J Med Genet. 74:1997;247-253.
14. Serretti A., Lilli R., Lorenzi C., Franchini L., Di Bella D., Catalano M., et al. Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. Psychiatry Res. 87:1999;7-19.
15. Serretti A., Macciardi F., Cusin C., Lattuada E., Lilli R., Di Bella D., et al. GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. Psychiatr Genet. 8:1998;251-254.
16. Shiah I.S., Yatham L.N. GABA function in mood disorders An update and critical review . Life Sci. 63:1998;1289-1303.
17. Sieghart W., Fuchs K., Tretter V., Ebert V., Jechlinger M., Hoger H., et al. Structure and subunit composition of GABA(A) receptors. Neurochem Int. 34:1999;379-385.
18. Weiss S.R., Post R.M. Kindling Separate vs. shared mechanisms in affective disorders and epilepsy . Neuropsychobiology. 38:1998;167-180.
19. Yamada K, Watanabe A, Iwayama-Shigeno Y, Yoshikawa T (in press): Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disorders. Neurosci Lett.