Novel antiarrhythmic compounds with combined class IB and class III mode of action

Current Medicinal Chemistry

Volumn 11, Issue 1, 2004, Pages 61-69

  Mátyus, Péter ^a   Varga, Ildikó ^b   Rettegi, Tivadar ^b   Simay, Antal ^b   Kállay, Nikolett ^a   Károlyházy, László ^a   Kocsis, Ákos ^a   Varró, András ^c   Pénzes, István ^d   Papp, Julius Gy ^c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b TEVA PHARMACEUTICALS   (Israel)

^c UNIVERSITY OF SZEGED   (Hungary)

^d Dept of Anesthesiol/Inten Therapy ^*  (Hungary)

Author keywords

Class I B; Class III antiarrhythmics; Dual mode of action; GYKI 16638; N (phenylalkyl) N (phenoxyalkyl)amines

Indexed keywords

ALIPHATIC AMINE; AMBASILIDE; AMIODARONE; ANTIARRHYTHMIC AGENT; CIBENZOLINE; DISOPYRAMIDE; DOFETILIDE; ENCAINIDE; FLECAINIDE; GYKI 16638; MEXILETINE; POTASSIUM CHANNEL BLOCKING AGENT; PROPAFENONE; PYRIDAZINONE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; SOTALOL; TOCAINIDE; UNCLASSIFIED DRUG;

ANTIARRHYTHMIC ACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DOG; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG USE; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; IN VIVO STUDY; MEDICAL DECISION MAKING; MEDICAL RESEARCH; MORTALITY; NONHUMAN; RABBIT; REVIEW; STRUCTURE ACTIVITY RELATION; TORSADE DES POINTES;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CORONARY DISEASE; DELAYED RECTIFIER POTASSIUM CHANNELS; DRUG DESIGN; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MEXILETINE; PAPILLARY MUSCLES; PHENETHYLAMINES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SOTALOL; SULFONAMIDES;

EID: 9144220806     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043456232     Document Type: Review

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