Pharmacological characterization of rebamipide: Its cholecystokinin CCK 1 receptor binding profile and effects on Ca 2+ mobilization and amylase release in rat pancreatic acinar cells

European Journal of Pharmacology

Volumn 505, Issue 1-3, 2004, Pages 61-66

  Moon, Seok Jun ^a   An, Jeong Mi ^a   Kim, Juyeon ^a   Lee, Syng Ill ^a   Ahn, Wooin ^b   Kim, Kyung Hwan ^b   Seo, Jeong Taeg ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Ca 2+ i oscillation; Amylase; Cholecystokinin CCK 1 receptor; Rebamipide

Indexed keywords

AMYLASE; CARBACHOL; CHOLECYSTOKININ A RECEPTOR; FORSKOLIN; REBAMIPIDE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACINAR CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME INHIBITION; ENZYME RELEASE; IC 50; MALE; NONHUMAN; OSCILLATION; PANCREAS CELL; PRIORITY JOURNAL; PROBABILITY; RAT; STRUCTURE ANALYSIS;

ALANINE; AMYLASES; ANIMALS; ANTIOXIDANTS; BINDING, COMPETITIVE; CALCIUM; CELLS, CULTURED; CHOLECYSTOKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; IODINE RADIOISOTOPES; KINETICS; PANCREAS; QUINOLONES; RATS; RECEPTOR, CHOLECYSTOKININ A; SINCALIDE; SUCCINIMIDES;

EID: 8844269126     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.10.032     Document Type: Article

References (26)

1. P. Bernfeld Amylase alpha and beta Methods Enzymol. 5 1955 139 148
2. 2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate EMBO J. 19 2000 2549 2557
3. H.Y. Gaisano, U.G. Klueppelberg, D.I. Pinon, M.A. Pfenning, S.P. Powers, and L.J. Miller Novel tool for the study of cholecystokinin-stimulated pancreatic enzyme secretion J. Clin. Invest. 83 1989 321 325
4. H.Y. Gaisano, D. Wong, L. Sheu, and J.K. Foskett Calcium release by cholecystokinin analogue OPE is IP3 dependent in single rat pancreatic acinar cells Am. J. Physiol. 267 1994 C220 C228
5. 2+ indicators with greatly improved fluorescent properties J. Biol. Chem. 260 1985 3440 3450
6. K. Haruma, and M. Ito Review article: clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide Aliment. Pharmacol. Ther. 18 2003 153 159
7. R. Herranz Cholecystokinin antagonists: pharmacological and therapeutic potential Med. Res. Rev. 23 2003 559 605
8. S. Iinuma, Y. Naito, T. Yoshikawa, S. Takahashi, T. Takemura, N. Yoshida, and M. Kondo In vitro studies indicating antioxidative properties of rebamipide Dig. Dis. Sci. 43 1998 35S 39S
9. 2+-dependent cell death in rat pancreatic acinar cells Gastroenterology 122 2002 1941 1953
10. 2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini J. Biol. Chem. 265 1990 6247 6254
11. 1 receptors in rat pancreatic acinar cells Eur. J. Pharmacol. 388 2000 17 20
12. K. Ochi, H. Harada, and K. Satake Clinical evaluation of cholecystokinin-A-receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan Digestion 60 1999 81 85
13. K. Ogino, T. Hobara, H. Ishiyama, K. Yamasaki, H. Kobayashi, Y. Izumi, and S. Oka Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats Eur. J. Pharmacol. 212 1992 9 13
14. M. Raraty, J. Ward, G. Erdemli, C. Vaillant, J.P. Neoptolemos, R. Sutton, and O.H. Petersen Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells Proc. Natl. Acad. Sci. U. S. A. 97 2000 13126 13131
15. H. Sankaran, I.D. Goldfine, C.W. Deveney, K.Y. Wong, and J.A. Williams Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini J. Biol. Chem. 255 1980 1849 1853
16. H.U. Schulz, C. Niederau, H. Klonowski-Stumpe, W. Halangk, R. Luthen, and H. Lippert Oxidative stress in acute pancreatitis Hepato-gastroenterol. 46 1999 2736 2750
17. J.Y. Seo, H. Kim, J.T. Seo, and K.H. Kim Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants Pharmacology 64 2002 63 70
18. E.A. Shaffer Review article: control of gall-bladder motor function Aliment. Pharmacol. Ther. 14 2000 2 8
19. H.A. Stark, C.M. Sharp, V.E. Sutliff, J. Martinez, R.T. Jensen, and J.D. Gardner CCK-JMV-180: a peptide that distinguishes high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors Biochim. Biophys. Acta 1010 1989 145 150
20. 2+ concentration J. Biol. Chem. 268 1993 18654 18658
21. J.B. Ward, O.H. Petersen, S.A. Jenkins, and R. Sutton Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis? Lancet 346 1995 1016 1019
22. J.A. Williams Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells Annu. Rev. Physiol. 63 2001 77 97
23. J.A. Williams, and G.T. Blevins Jr. Cholecystokinin and regulation of pancreatic acinar cell function Physiol. Rev. 73 1993 701 723
24. S.C. Woods Gastrointestinal satiety signals: I. An overview of gastrointestinal signals that influence food intake Am. J. Physiol.: Gasterointest. Liver Physiol. 286 2004 G7 G13
25. K. Yamasaki, T. Kanbe, T. Chijiwa, H. Ishiyama, and S. Morita Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat Eur. J. Pharmacol. 142 1987 23 29
26. i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion Biochim. Biophys. Acta 1136 1992 175 180