Quantification of residual EDU (N-ethyl-N′-(dimethylaminopropyl) carbodiimide (EDC) hydrolyzed urea derivative) and other residual by LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 813, Issue 1-2, 2004, Pages 103-112

  Lei, Q Paula ^a   Lamb, David H ^a   Shannon, Anthony G ^a   Cai, Xinxing ^a   Heller, Ronald K ^a   Huang, Michael ^a   Zablackis, Earl ^a   Ryall, Robert ^a   Cash, Patricia ^a  

^a Aventis Pasteur   (United States)

Author keywords

Assay transfer; LC MS; Polysaccharide protein conjugate vaccine; Quantification; Residual material; Validation

Indexed keywords

CARBODIIMIDE; COUPLING REAGENTS;

DERIVATIVES; HYDROLYSIS; POLYSACCHARIDES; QUALITY CONTROL; UREA; VACCINES;

CHROMATOGRAPHY;

DIPHTHERIA VACCINE; EDOXUDINE; LYSINE; MENINGOCOCCUS VACCINE;

ACCURACY; ARTICLE; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETHYLDIMETHYLAMINOPROPYL CARBODIIMIDE; HYDROLYSIS; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 8844256615     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.09.015     Document Type: Article

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