Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 24, 2004, Pages 6343-6349

  Sekine, Mitsuo ^a,b   Okada, Kazuhisa ^a   Seio, Kohji ^a,b   Obata, Tohru ^c   Sasaki, Takuma ^c   Kakeya, Hideaki ^d   Osada, Hiroyuki ^d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d Japan Science and Technology Agency   (Japan)

Author keywords

8 Oxoadenosine; Aminoacyl adenylate analog; Antitumor activity; Phosmidosine; Structure activity relationship

Indexed keywords

6 N [N [3,6 DIOXA 8 (BIOTINYLAMIDO)OCTYL]CARBAMOYL] 2',3' O ISOPROPYLIDENE 7,8 DIHYDRO 8 OXOADENOSINE 5' ETHYL N (LEVO PROPYL)PHOSPHORAMIDATE; 6 N [N [3,6 DIOXA 8 [N' (4,4' DIMETHOXYTRITYL)BIOTINYLAMIDO]OCTYL] CARBAMOYL] 2',3' O ISOPROPYLIDENE 7,8 DIHYDRO 8 OXOADENOSINE; 6 N [N [3,6 DIOXA 8 [N' (4,4' DIMETHOXYTRITYL)BIOTINYLAMIDO]OCTYL] CARBAMOYL] 2',3' O ISOPROPYLIDENE 7,8 DIHYDRO 8 OXOADENOSINE 5' ETHYL N (N TRITYL LEVO PROPYL)PHOSPHORAMIDATE; 6 N ACETYLPHOSMIDOSINE; ADENOSINE DERIVATIVE; ANTINEOPLASTIC AGENT; FORMIC ACID DERIVATIVE; FUNCTIONAL GROUP; PHENYLCHLOROFORMATE; PHOSMIDOSINE; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BIOTIN; CELL LINE, TUMOR; CELL SURVIVAL; G1 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; PURINE NUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8844249960     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.037     Document Type: Article

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