Structure-activity relationship of phosmidosine: Importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 19, 2004, Pages 5193-5201

  Sekine, Mitsuo ^a   Okada, Kazuhisa ^a   Seio, Kohji ^a,b   Kakeya, Hideaki ^c   Osada, Hiroyuki ^c   Sasaki, Takuma ^d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

8 Oxoadenosine; Aminoacyl adenylate analog; Antitumor activity; Phosmidosine; Structure activity relationship

Indexed keywords

6 N ACETYL 7,8 DIHYDRO 8 OXODEOXYADENOSINE 5' [ETHYL N (PROLYL) PHOSPHOROAMIDATE]; 6 N ACETYLADENINE; 7,8 DIHYDRO 8 OXODEOXYADENOSINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE]; ADENINE; ADENOSINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE]; ADENOSINE PHOSPHATE; ANTINEOPLASTIC AGENT; CYTIDINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE]; DEOXYADENOSINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE]; GUANOSINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE]; N DIISOPROPYL N' (N TRITYLPROLYL)PHOSPHORODIAMIDITE; NUCLEOSIDE DERIVATIVE; PHOSPHORUS DERIVATIVE; PROLYLADENOSINE 5' PHOSPHATE; UNCLASSIFIED DRUG; URIDINE 5' [ETHYL N (PROLYL)PHOSPHOROAMIDATE];

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PEPTIDE SYNTHESIS; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYADENOSINES; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN BIOSYNTHESIS; PURINE NUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4444229909     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.021     Document Type: Article

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