Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia

Journal of Surgical Research

Volumn 122, Issue 2, 2004, Pages 263-273

  Alizadeh, Navid ^a   Pittet, Brigitte ^a   Tenorio, Xavier ^a   Pyke, Charles ^b   Baetens, Danielle ^c   Schlaudraff, Kai Uwe ^a   Montandon, Denys ^a   Ezban, Mirella ^b   Pepper, Michael S ^a,c,d  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d University Medical Center   (Switzerland)

Author keywords

anticoagulant; flap; FVIIai; ischemia; necrosis; rat; skin; thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 7A INHIBITOR; RIBONUCLEASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ANALYSIS; FEMALE; GRAFT SURVIVAL; HEMOSTASIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LASER DOPPLER FLOWMETRY; MICROVASCULAR ISCHEMIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTIAL THROMBOPLASTIN TIME; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; SKIN BLOOD FLOW; SKIN FLAP SURVIVAL; SKIN NECROSIS; SKIN PROTECTION; SPECIES COMPARISON; TISSUE STRUCTURE;

ACUTE DISEASE; ANIMALS; BLOOD COAGULATION; FACTOR VIIA; FEMALE; ISCHEMIA; NECROSIS; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; SKIN; SURGICAL FLAPS; THROMBOPLASTIN; THROMBOSIS; TIME FACTORS; TISSUE SURVIVAL;

EID: 8844224232     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2004.06.014     Document Type: Article

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