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8744225720
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note
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(b) Sigma-Aldrich pricing: N,O-dimethylhydroxylamine•HCl costs $195/mol, while morpholine is only $13/mol (calculation based on 100 g bottles).
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47
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37049108024
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Dimethylphenylsilyllithium is easily prepared from the incubation of commercially available dimethylphenylsilyl chloride and finely cut lithium metal in THF at 0°C for 40 h. The resulting dark red suspension is used after titration according to: Fleming, I.; Newton, T. W.; Roessler, F. J. Chem. Soc., Perkin Trans. 1 1981, 2527-2532.
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8744256820
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note
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Table 2, entry 3, has been performed on a 55 mmol scale to yield acylsilane 3c. See Supporting Information for details.
-
-
-
-
51
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8744296177
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note
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Employing additional 2-substituted aromatic heterocycles (e.g., N-methyl pyrroyl, thiophen-2-yl) was not successful using the current reaction conditions.
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