Genetic approaches to solving common diseases

Journal of Neurology

Volumn 251, Issue 10, 2004, Pages 1169-1172

  Abou Sleiman, P M ^a   Healy, D G ^a   Wood, N W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Genetics; Haplotype; Population; Tagging

Indexed keywords

ALLELE; BRAIN CORTEX; DATA ANALYSIS; DRUG SENSITIVITY; EPILEPSY; FAMILIAL DISEASE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; GENOMICS; HIGH RISK POPULATION; HUMAN; INHERITANCE; MUSCLE; NEUROLOGIC DISEASE; NEUROSCIENCE; PARAMETER; PHARMACOGENOMICS; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; STATISTICAL ANALYSIS; TECHNIQUE; TREATMENT OUTCOME;

CHROMOSOME MAPPING; GENETIC PREDISPOSITION TO DISEASE; GENETICS, MEDICAL; GENETICS, POPULATION; HUMANS; NERVOUS SYSTEM DISEASES; PHARMACOGENETICS;

EID: 8744285359     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-004-0518-9     Document Type: Review

References (17)

1. Ardlie et al. (2002) Testing for population subdivision and association in four case control studies. Am J Hum Genet 71:304-311
2. Daly MJ et al. (2001) High-resolution haplotype structure in the human genome. Nat Gen 29:229-232
3. Freedman ML, Reich D, Penney KL et al. (2004) Assessing the impact of population stratification on genetic association studies. Nat Genet 36: 388-393
4. Gwinn-Hardy K, Farrer M (2002) Parkinson's genetics: An embarrassment of Riches. Ann Neurol 51:7-8
5. Goldstein, DB (2001). Islands of linkage disequilibrium. Nat Genet 29: 109-111
6. Goldstein DB, Weale ME (2001) Population Genomics: Linkage disequilibrium holds the key. Curr Biol 11: R576-R579
7. Jeffrys et al. (2001) Intensely punctuate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet 29:217-222
8. Johnson GCL et al. (2001) Haplotype tagging for the identification of common disease genes. Nat Genet 29: 233-237
9. Kruglyak L, Lander ES (1995) High-resolution genetic mapping of complex traits. Am J Hum Genet 56: 1212-1223
10. Pritchard JK et al. (2000) Association Mapping in Structured Populations. Am J Hum Genet 67:170-181
11. Ramsden DB, Parsons RB, Ho SL, Xie T, Waring RH, Williams AC (2001) Further studies in xenobiotic metabolism and Parkinson's disease. Adv Neurol 86:105-113
12. Reich DE, Goldstein DB (2001) Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol 20:4
13. Reich DE, Lander ES, et al. (2001) Linkage disequilibrium in the human genome. Nature 4:199-204
14. Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 348:1442-1448
15. Spacey SD, Wood NW (1999) The genetics of Parkinson's disease. Current Opin Neurol 12:427-432
16. Weiss KM, Terwilliger JD (2000) How many diseases does it take to map a gene with SNPs? Nat Genet 26:151-157
17. Wright AF, Carothers AD, Pirastu M (1999) Population choice in mapping genes for complex diseases. Nat Genet 23:397