Utilizing alternate target cells in treating HIV infection through scheduled treatment interruptions

Proceedings of the American Control Conference

Volumn 1, Issue , 2004, Pages 946-951

  Zurakowski, Ryan ^a   Teel, Andrew R ^a   Wodarz, Dominik ^b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIV INFECTION; HUMAN IMMUNE RESPONSE; IMMUNE CONTROL; MODEL PREDICTIVE CONTROL (MPC);

ANTIGENS; DISEASE CONTROL; IMMUNOLOGY; PATHOLOGY; PATIENT MONITORING; PREDICTIVE CONTROL SYSTEMS; VIRUSES;

CELLS;

EID: 8744275605     PISSN: 07431619     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (14)

1. D. Douek, J. Brenchley, M. Betts, D. Ambrozak, B. Hill, Y. Okamoto, J. Casazza, J. Kuruppu, K. Kunstman, S. Wollnsky, Z. Grossman, M. Dybul, A. Oxenlus, D. Price, M. Conners, and R. Koup. HIV preferentially infects HIV-specifi c CD4+ T cells. Nature, 417, 2002.
2. F. Garcia, M. Plana, G. Ortiz, S. Bonhoeffer, A. Soriano, C. Vidal, A. Cruceta, M. Arnedo, C. Gil, G. Pantaleo, T. Pumarola, T. Gallart, D. Nixon, J. Miro, and J. Gatell. The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection. AIDS, 15(9), 2001.
3. G. Grimm, M. J. Messina, A. R. Teel, and S. E. Tuna. Model predictive control when a local control lyapunov function is not available. In Proceedings of the 2003 American Control Conference, June 2003.
4. M. D. Hazenberg, S. A. Otto, B. H. B. van Benthem, M. T. L. Roos, R. A. Coutinho, J. M. A. Lange, D. Hamann, M. Prins, and F. Miedema. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS, 17(13):1881-8, Sep 2003.
5. P. Hunt, J. Martin, E. Sinclair, B. Bredt, E. Hagos, H. Lampiris, and S. Deeks. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus infected patients with sustained viral suppression during antiretroviral therapy. Journal of Infectious Diseases, 187(10), 2003.
6. C. M. Kellert and A. R. Teel. On robustness of stability and lyapunov functions for discontinuous difference equations. In Proceedings of the 41st IEEE Control and Decision Conference, Dec. 2002.
7. G. Ortiz, D. Nixon, A. Trkola, J. Binley, X. Jin, S. Bonhoeffer, P. Kuebler, S. Donahoe, M.-A. Demoitie, W. Kakimoto, T. Ketas, B. Clas, J. Heymann, L. Zhang, Y. Cao, A. Hurley, J. Moore, D. Ho, and M. Markowitz. HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. Journal of Clinical Immunology, 104, 1999.
8. Papagno, Spina, Marchant, Salio, Rufer, Little, Dong, Chesney, Waters, Easterbrook, Dunbar, Shepherd, Cerundolo, Emery, Griffi ths, Conlon, McMichael, Richman, Rowland-Jones, and Appay. Immune Activation and CD8(+) T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol, 2(2):E20, Feb 2004.
9. E. Papasavvas, G. Ortiz, R. Gross, J. Sun, E. C. Moore, J. Heymann, M. Moonis, J. K. Sandberg, L. A. Drohan, B. Gallagher, J. Shull, D. F. Nixon, J. Kostman, and L. Montaner. Enhancement of human immunodeficiency virus type 1-specific CD4 and CDS T cell responses in chronically infected patients after long-term viral suppression. Journal of Infectious Diseases, 182, 2000.
10. E. Rosenberg, M. Altfeld, S. Poon, M. Phillips, B. Wilkes, R. Eldridge, G. Robbins, R. D'Aquila, P. Goulder, and B. Walker. Immune control of HIV-1 after early treatment of acute infection. Nature, 407, 2000.
11. D. Wodarz. Helper-dependent vs. helper-independent CTL responses in HIV infection. Journal of Theoretical Biology, 213, 2001.
12. D. Wodarz, R. Arnaout, M. Nowak, and J. Lifson. Transient antiretroviral treatment during acute simian immunodefi ciency virus infection facilitates long-term control of the virus. Philosophical Transactions of the Royal Society of London in Biology, 355, 2000.
13. D. Wodarz and M. A. Nowak. Specifi c therapy regimes could lead to long-term immunological control of HIV. Proceedings of the National Academy of Sciences, 96(25), 1999.
14. R. Zurakowski and A. R. Teel. Enhancing immune response to HIV infection using MPC-based treatment scheduling. In Proceedings of the 2003 American Control Conference, June 2003.