Efficient synthesis of 4-(3-fluoro-5-{[4-(2-methyl-1h-imidazol-1-yl)benzyl] -oxy}phenyl)tetrahydro-2h-pyran-4-carboxamide, a novel 5-lipoxygenase inhibitor

Synthesis

Volumn , Issue 16, 2004, Pages 2625-2628

  Mano, Takashi ^a   Stevens, Rodney W ^a   Nakao, Kazunari ^a   Okumura, Yoshiyuki ^a   Kawamura, Kiyoshi ^a   Ando, Akemi ^a   Matsuoka, Yoko ^a  

^a PFIZER INC   (United States)

Author keywords

Amides; Cyclizations; Drugs; Nitriles; Nucleophilic aromatic substitutions

Indexed keywords

AROMATIC COMPOUNDS; ENZYME INHIBITION; ENZYMES; ETHERS; HYDROLYSIS; SUBSTITUTION REACTIONS;

CARBOXAMIDE; CYCLIZATION; FACILE CONSTRUCTION;

SYNTHESIS (CHEMICAL);

4 [3 FLUORO 5 [[4 (2 METHYL 1H IMIDAZOL 1 YL)BENZYL]OXY]PHENYL]TETRAHYDRO 2H PYRAN 4 CARBOXAMIDE; AMIDE; DIMETHYL SULFOXIDE; DIPHENYL ETHER DERIVATIVE; LIPOXYGENASE INHIBITOR; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

EID: 8744222299     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-831227     Document Type: Article

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