Toluene and p-xylene induced LLC-PK1 apoptosis

Drug and Chemical Toxicology

Volumn 27, Issue 4, 2004, Pages 425-432

  Al Ghamdi, Saeed S ^a   Raftery, Martin J ^b   Yaqoob, Muhammad M ^b  

^a UMM AL QURA UNIVERSITY   (Saudi Arabia)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Apoptosis; LLC PK1; Proximal tubular cells; Toluene; Xylene

Indexed keywords

TOLUENE; XYLENE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CHRONIC KIDNEY FAILURE; ENZYME RELEASE; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; NONHUMAN; OCCUPATIONAL TOXICOLOGY; SWINE; TOXICITY TESTING;

ANIMALS; APOPTOSIS; CELL LINE; DNA FRAGMENTATION; KIDNEY TUBULES, PROXIMAL; SWINE; TOLUENE; XYLENES;

ANIMALIA; SUS SCROFA;

EID: 8644284290     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-200039782     Document Type: Article

References (21)

1. Al-Ghamdi, S., Raftery, M., Yaqoob, M. (2003a). Acute solvent exposure induced activation of cytochrome P4502E1 causes proximal tubular cell necrosis by oxidative stress. Toxicol. In Vitro 17:335-341.
2. Al-Ghamdi, S. S., Raftery, M. J., Yaqoob, M. M. (2003b). Organic solvent-induced proximal tubular cell toxicity via caspase-3 activation. J. Toxicol., Clin. Toxicol. 41:967-971.
3. Arechabala, B., Coiffard, C., Rivalland, P., Coiffard, L. J., de Roeck-Holtzhauer, Y. (1999). Comparison of cytotoxicity of various surfactants tested on normal human fibroblast cultures using the neutral red test, MTT assay and LDH release. J. Appl. Toxicol. 19:163-165.
4. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
5. Halliwell, B., Gutteridge, M. C. (1999). Free Radicals in Biology and Medicine. 3rd ed. London: Oxford University Press.
6. Heining, P., Hoffmann, R. W. (1993). Light- and electron microscopical studies on the prolonged toxicity of trichloroethylene on rainbow trout (Oncorhynchus mykiss). Exp. Toxicol. Pathol. 45:167-176.
7. Hickey, E. J., Raje, R. R., Reid, V. E., Gross, S. M., Ray, S. D. (2001). Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic. Biol. Med. 31:139-152.
8. Lin, H. J., Shaffer, K. M., Chang, Y. H., Barker, J. L., Pancrazio, J. J., Stenger, D. A., Ma, W. (2002). Acute exposure of toluene transiently potentiates p42/44 mitogen-activated protein kinase (MAPK) activity in cultured rat cortical astrocytes. Neurosci. Lett. 332:103-106.
9. Malich, G., Markovic, B., Winder, C. (1997). The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines. Toxicology 124:179-192.
10. Mutti, A., Coccini, T., Alinovi, R., Toubeau, G., Broeckaert, F., Bergamaschi, E., Mozzoni, P., Nonclercq, D., Bernard, A., Manzo, L. (1999). Exposure to hydrocarbons and renal disease: an experimental animal model. Ren. Fail. 21:369-385.
11. Narvarte, J., Saba, S. R., Ramirez, G. (1989). Occupational exposure to organic solvents causing chronic tubulo-interstitial nephritis. Arch. Intern. Med. 149:154-159.
12. Ortiz, A. (2000). Nephrology forum: apoptotic regulatory proteins in renal injury. Kidney Int. 58:467-485.
13. Ortiz, A., Cuadrado, S. G., Lorz, C., Egido, J. (1996). Apoptosis in renal diseases. Front. Biosci. 1:D30-D47.
14. Ravnskov, U. (2000). Hydrocarbon exposure may cause glomerulonephritis and worsen renal function: evidence based on Hill's criteria for causality. Q. J. Med. 93 (8):551-556.
15. Sato, T., van Dixhoorn, M. G., Schroeijers, W. E., Huizinga, T. W., Reutelingsperger, C. P., Dana, M. R. (1996). Apoptosis of cultured rat glomerular mesangial cells induced by IgG2a monoclonal anti-Thy-1 antibodies. Kidney Int. 49:403-412.
16. Seaton, A. (1992). Organic solvents and the nervous system: time for a reappraisal? Q. J. Med. 84:637-639.
17. Thomas, G. L., Yang, B., Wagner, B. E., Savill, J., El Nahas, A. M. (1998). Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol. Dial. Transplant. 13:2216-2226.
18. Virag, L., Marmer, D. J., Szabo, C. (1998). Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation. Free Radic. Biol. Med. 25:1075-1082.
19. Yaqoob, M., Bell, G. M., Percy, D., Finn, R. (1992). Primary glomerulonephritis and hydrocarbon exposure: a case control study and literature review. Q. J. Med. 301:409-418.
20. Yaqoob, M., Patrick, A. W., McClelland, P., Stevenson, A., Mason, H., Percy, D. F., White, M. C., Bell, G. M. (1994a). Occupational hydrocarbon exposure in diabetic nephropathy. Diabet. Med. 11:789-793.
21. Yaqoob, M., King, A., Mclelland, P., McDicken, L, Bell, G. M. (1994b). Relationship between hydrocarbon exposure and nephrotoxicity in primary glomerulonephritis. Nephrol. Dial. Transplant. 9:1575-1579.