Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humans

Atherosclerosis

Volumn 177, Issue 2, 2004, Pages 443-450

  Korstanje, Ron ^a   Eriksson, Per ^b   Samnegård, Ann ^b   Olsson, Per G ^c   Forsman Semb, Kristina ^c   Sen, Saunak ^a   Churchill, Gary A ^a   Rollins, Jarod ^a   Harris, Stephen ^d   Hamsten, Anders ^b   Paigen, Beverly ^a  

^a JACKSON LABORATORY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

ANGPTL3; Atherosclerosis; Mouse; QTL

Indexed keywords

AMINO ACID; ANGIOPOIETIN LIKE PROTEIN 3; ARACHIDONIC ACID EPOXYGENASE; ENZYME; FIBRINOGEN; PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATH8 GENE; ATHEROSCLEROSIS; BASE PAIRING; CHROMOSOME 4; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; INBRED STRAIN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANIMALS; ARTERIOSCLEROSIS; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOD SCORE; MICE; MICE, INBRED STRAINS; QUANTITATIVE TRAIT LOCI;

EID: 8644282049     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.08.006     Document Type: Article

References (27)

1. B. Paigen, D. Mitchell, and K. Reue Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice Proc Natl Acad Sci USA 84 1987 3763 3767
2. J.L. Mu, J.K. Naggert, and K.L. Svenson Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J J Lipid Res 40 1999 1328 1335
3. M. Mehrabian, J. Wong, and X. Wang Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia Circ Res 89 2001 125 130
4. C.L. Welch, S. Bretschger, and N. Latib Localization of atherosclerosis susceptibility loci to chromosome 4 and 6 using the Ldlr knockout mouse model ProcNatl Acad Sci USA 98 2001 7946 7951
5. H.M. Dansky, P. Shu, and M. Donavan A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse Genetics 160 2002 1599 1608
6. B. Paigen Genetics of responsiveness to high-fat and high-cholesterol diets in the mouse Am J Clin Nutr 62 1995 458S 462S
7. D.A. Purcell-Huynh, A. Weinreb, and L.W. Castellani Genetic factors in lipoprotein metabolism: analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach J Clin Invest 96 1995 1845 1858
8. W.A. Pitman, M.H. Hunt, C. McFarland, and B. Paigen Genetic analysis of the difference in diet-induced atherosclerosis between the inbred mouse strains SM/J and NZB/BINJ Arterioscler Thromb VascBiol 18 1998 615 620
9. P.M. Nishina, J. Verstuyft, and B. Paigen Synthetic low and high fat diets for the study of atherosclerosis in the mouse J Lipid Res 31 1990 859 869
10. B. Paigen, A. Morrow, P.A. Holmes, D. Mitchell, and R.A. Williams Quantitative assessment of atherosclerotic lesions in mice Atherosclerosis 68 1987 231 240
11. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
12. P. Eriksson, H. Deguchi, and A. Samnegard Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease Arterioscler Thromb Vasc Biol. 24 3 2004 551 557
13. M. Ronaghi, M. Uhlen, and P. Nyren A sequencing method based on real-time pyrophosphate Science 281 1998 363 364
14. K.W. Broman Mapping quantitative trait loci in the case of a spike in the phenotype distribution Genetics 163 2003 1169 1175
15. G.A. Sen SChurchill A statistical framework for quantitative trait mapping Genetics 159 2001 371 387
16. S. Kiechl, C.J. Wiedermann, and J. Willeit Toll-like receptor 4 and atherogenesis Ann Med 35 2003 164 171
17. I. Smirnova, A. Poltorak, E.K.L. Chan, C. McBride, and B. Beutler Phylogenetic variation and polymorphism at the Toll-loke receptor 4 locus (Tlr4) Genome Biol 1 2000 002.1 002.10
18. M. Mehrabian, H. Allayee, and J. Wong Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circ Res 91 2002 120 126
19. D. Conklin, D. Gilbertson, and D.W. Taft Identification of a mammalian angiopoietin-related protein expressed specifically in liver Genomics 62 1999 477 482
20. R. Koishi, Y. Ando, and M. Ono Angptl3 regulates lipid metabolism in mice Nat Genet 30 2002 151 157
21. T. Shimizugawa, M. Ono, and M. Shimamura ANGPTL3 decreases very low denstiy lipoprotein triglyceride clearance by inhibition of lipoprotein lipase J Biol Chem 277 2002 33742 33748
22. G. Camenisch, M.T. Pisabarro, and D. Sherman ANGPTL3 stimulates endothelial cell adhesion and migration via integrin avb3 and induces blood vessel formation in vivo J Biol Chem 277 2002 17281 17290
23. Y. Ando, T. Shimizugawa, and S. Takeshita A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice J Lipid Res 2003
24. S. Wang, W. Shi, X-P. Wang, A. Ghazalpour, and A.J. Lusis Identification of a locus in ice that influences aortic aneurysm formation Proceedings of the AHA Scientific Sessions 2003 Orlando, FL, USA 2003 837
25. S. Kiechl, E. Lorenz, and M. Reindl Toll-like receptor 4 polymorphisms and atherogenesis New England J Med 347 2002 185 192
26. N.C. Arbour, E. Lorenz, and B.C. Schutte TLR4 mutations are associated with endotoxin hyporesponsiveness in humans Nat Genet 25 2000 187 191
27. M. Ono, T. Shimizugawa, and M. Shimamura Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3) J Biol Chem 278 2003 41804 41809