Invariant aspartic acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding

Journal of General Physiology

Volumn 124, Issue 5, 2004, Pages 555-567

  Lee, Won Yong ^a,b   Sine, Steven M ^a  

^a Mayo Clinic College of Medicine   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Acetylcholine receptor; Hydrogen bond; Ligand binding site; Single channel kinetics; Structural model

Indexed keywords

ACETYLCHOLINE; ASPARTIC ACID; BINDING PROTEIN; HYDROXYL GROUP; LIGAND; NICOTINIC RECEPTOR;

ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; HYDROGEN BOND; KINETICS; LIGAND BINDING; MODEL; MOLECULAR INTERACTION; MUSCLE SPINDLE; MUTATION; PATCH CLAMP; RECEPTOR BINDING; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ASPARTIC ACID; BINDING SITES; CELL LINE; HUMANS; KIDNEY; KINETICS; LIGANDS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8644263906     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200409077     Document Type: Article

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