Synthesis of galanthamine analogs as acetylcholinesterase inhibitors via intramolecular heck cvclization

Journal of the Chinese Chemical Society

Volumn 50, Issue 3 A, 2003, Pages 449-456

  Liang, Pi Hui ^a   Hsin, Ling Wei ^a   Pong, Sung Ling ^a   Hsu, Chia Huei ^a   Cheng, Chen Yu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Galanthamine; Intramolecular heck reaction

Indexed keywords

EID: 8644234636     PISSN: 00094536     EISSN: None     Source Type: Journal    
DOI: 10.1002/jccs.200300071     Document Type: Article

References (23)

1. Mucke, H. A. M. Drugs Today 1997, 33, 251.
2. Weinstock, M. CNS Drugs 1999, 12, 307.
3. Rainer, M. Drugs Today 1997, 33, 273.
4. Hoshino, O. In The Alkaloids; Cordell, G. A., Ed.; Academic Press: New York, 1998; Vol. 51, p 323.
5. Martin, S. F. In The Alkaloids; Brossi, A., Ed.; Academic Press: New York, 1987; Vol. 30, p 251.
6. Shieh, W.-C; Carlson, J. A. J. Org. Chem. 1994, 59, 5463.
7. Barton, D. H. R.; Kirby, G. W. J. Chem. Soc. 1962, 806.
8. Kametani, T.; Yamaki, K.; Terui, T. J. Heterocycl. Chem. 1973, 10, 35.
9. Vlahov, R,; Krikorian, D.; Spassov, G.; Chinoua, M.; Ulahov, F.; Parushev, S.; Snatzke, G.; Ernst, L.; Klieslich, K.; Abraham, W.-R.; Sheldrick, W. S. Tetrahedron 1988, 45, 3329.
10. Szewczyk, J.; Wilson, J. W.; Lewin, A, H.; Carroll, F. I. J. Heterocycl. Chem. 1995, 32, 195.
11. Chaplin, D. A.; Fraser, N.; Tiffin, P. D. Tetrahedron Lett. 1997, 38, 7931.
12. Kita, Y.; Arisawa, M.; Gyoten, M.; Nakajima, M.; Hamada, R.; Tohma, H.; Takada, T. J. Org. Chem. 1998, 63, 6625.
13. Kuenburg, B.; Czollner, L.; Frohlich, J.; Jordis, U. Org. Process Res. Rev. 1999, 3, 425.
14. Cheng, C. Y.; Liou, J. P.; Lee, M. J. Tetrahedron Lett. 1997, 38, 4571.
15. Tasi, Y. C.; Liou, J. P.; Liao, R.; Cheng, C. Y; Tao, P. L. Bioorg. Med. Chem. Lett. 1998, 8, 1813.
16. Liou, J. P.; Cheng, C. Y. Tetrahedron Lett. 2000, 41, 915.
17. Mitsnobu O. Synthesis 1981, 1, 1.
18. Jeffery, T. Tetrahedron 1996, 52, 10113.
19. Abelman, M. M.; Oh, T.; Overman, L. E. J. Org. Chem. 1987, 52, 4130.
20. Lee, M. J., PhD. thesis, National Taiwan University, July. 1999.
21. Czollner, L.; Frantstis, W.; Kuenburg, B.; Heenig, U.; Frohlich, J.; Jordis, U. Tetrahedron Lett. 1998, 39, 2087.
22. Ellman, G. L.; Courtney, K, D.; Valentino, A. Jr.; Featherstone, R. M. Biochemical Pharmacology 1961, 7, 85.
23. Bartolucci, C; Perola, E.; Pilger, C.; Fels, G.; Lamba, D. Proteins: Struct, Funct, Genet 2001, 42, 182.