Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 18, 2004, Pages 4735-4739

  Snyder, Lawrence B ^a   Meng, Zhaoxing ^a   Mate, Robert ^a   D'Andrea, Stanley V ^a   Marinier, Anne ^a   Quesnelle, Claude A ^a   Gill, Patrice ^a   Den Bleyker, Kenneth L ^a   Fung Tomc, Joan C ^a   Frosco, MaryBeth ^a   Martel, Alain ^a   Barrett, John F ^a   Bronson, Joanne J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antibacterial; Bioisostere; Isoxazolinone; Oxazolidinone

Indexed keywords

ANTIINFECTIVE AGENT; ISOXAZOLIDINE DERIVATIVE; NITROGEN; OXAZOLIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; ATOM; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; NITROGEN; OXAZOLIDINONES; OXAZOLONE; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8544282444     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.076     Document Type: Article

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