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Volumn 76, Issue 6, 1997, Pages 812-818

Prognostic relevance of urokinase plasminogen activator detection in micrometastatic cells in the bone marrow of patients with primary breast cancer

Author keywords

Breast cancer; Micrometastasis; Prognostic factor; Tumour cell detection; Urokinase plasminogen activator (uPA)

Indexed keywords

ANTIBODY; CYCLOPHOSPHAMIDE; FLUOROURACIL; GLYCOPROTEIN; METHOTREXATE; TAMOXIFEN; UROKINASE;

EID: 8544263800     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.467     Document Type: Article
Times cited : (43)

References (47)
  • 1
    • 4243262152 scopus 로고
    • Monoclonal antibodies against breast cancer
    • Rygaard K, Brünner N and Spang-Thomsen M. (eds), S Karger: Basle
    • Bastert G, Eichler A and Kaul S (1987) Monoclonal antibodies against breast cancer. In Immune Deficient Animals in Biomedical Research, Rygaard K, Brünner N and Spang-Thomsen M. (eds), pp. 224-227. S Karger: Basle
    • (1987) Immune Deficient Animals in Biomedical Research , pp. 224-227
    • Bastert, G.1    Eichler, A.2    Kaul, S.3
  • 4
    • 0029992385 scopus 로고    scopus 로고
    • Immunohistochemical localisation of urokinase-type plasminogen activator, type-1 plasminogen activator inhibitor, urokinase receptor and α(2)macroglobulin receptor in human breast carcinomas
    • Christensen L, Wiborg-Simonsen AC, Heegaard CW, Moestrup SK, Anderson JA and Andreasen PA (1996) Immunohistochemical localisation of urokinase-type plasminogen activator, type-1 plasminogen activator inhibitor, urokinase receptor and α(2)macroglobulin receptor in human breast carcinomas. Int J Cancer 66: 441-452
    • (1996) Int J Cancer , vol.66 , pp. 441-452
    • Christensen, L.1    Wiborg-Simonsen, A.C.2    Heegaard, C.W.3    Moestrup, S.K.4    Anderson, J.A.5    Andreasen, P.A.6
  • 6
    • 0029968743 scopus 로고    scopus 로고
    • Combined overexpression of urokinase, urokinase receptor, and plasminogen activator inhibitor 1 is associated with breast cancer regression: An immunohistochemical comparison of normal, begnign and malignant breast tissues
    • Constantini V, Sidoni A, Deveglia R, Cattato OA, Welleza G, Ferri I, Bucciarelli E and Nenci GG (1996) Combined overexpression of urokinase, urokinase receptor, and plasminogen activator inhibitor 1 is associated with breast cancer regression: an immunohistochemical comparison of normal, begnign and malignant breast tissues. Cancer 77: 1079-1088
    • (1996) Cancer , vol.77 , pp. 1079-1088
    • Constantini, V.1    Sidoni, A.2    Deveglia, R.3    Cattato, O.A.4    Welleza, G.5    Ferri, I.6    Bucciarelli, E.7    Nenci, G.G.8
  • 7
    • 0026003325 scopus 로고
    • Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases
    • Cote RJ, Rosen PP, Lesser ML, Old LJ and Osborne MP (1991) Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 9: 1749-1756
    • (1991) J Clin Oncol , vol.9 , pp. 1749-1756
    • Cote, R.J.1    Rosen, P.P.2    Lesser, M.L.3    Old, L.J.4    Osborne, M.P.5
  • 8
    • 0000336139 scopus 로고
    • Regression models and life-tables
    • Cox DR (1972) Regression models and life-tables. J R Stat Soc (B) 34: 187-220
    • (1972) J R Stat Soc (B) , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 9
    • 0027095768 scopus 로고
    • Detection of tumor cells in bone marrow of patients with primary breast cancer: A prognostic factor for distant metastasis
    • Diel IJ, Kaufmann M, Goerner R, Costa SD, Kaul S and Bastert G (1992) Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis. J Clin Oncol 10: 1534-1539
    • (1992) J Clin Oncol , vol.10 , pp. 1534-1539
    • Diel, I.J.1    Kaufmann, M.2    Goerner, R.3    Costa, S.D.4    Kaul, S.5    Bastert, G.6
  • 10
    • 0028249876 scopus 로고
    • Monoclonal antibodies to detect breast cancer cells
    • DeVita VT, Hellman S and Rosenberg SA. (eds), Lippincott: Philadelphia
    • Diel IJ, Kaufmann M, Costa SD and Bastert G (1994) Monoclonal antibodies to detect breast cancer cells. In: Important Advances in Oncology. DeVita VT, Hellman S and Rosenberg SA. (eds), pp. 143-164. Lippincott: Philadelphia
    • (1994) Important Advances in Oncology , pp. 143-164
    • Diel, I.J.1    Kaufmann, M.2    Costa, S.D.3    Bastert, G.4
  • 11
    • 0029804573 scopus 로고    scopus 로고
    • Breast cancer patients with micrometastatic tumor cells in bone marrow at primary surgery - Prognostic impact in comparison to nodal status
    • Diel IJ, Kaufmann M, Costa SD, Holle R, Von Minckwitz G, Solomayer EF, Kaul S and Bastert G (1996) Breast cancer patients with micrometastatic tumor cells in bone marrow at primary surgery - prognostic impact in comparison to nodal status. J Natl Cancer Inst 88: 1652-1658
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1652-1658
    • Diel, I.J.1    Kaufmann, M.2    Costa, S.D.3    Holle, R.4    Von Minckwitz, G.5    Solomayer, E.F.6    Kaul, S.7    Bastert, G.8
  • 12
  • 13
    • 0028114470 scopus 로고
    • Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer
    • Duffy MJ, Reilly D, McDermott E, O'Higgins N, Fennelly JJ and Andreasen PA (1994) Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer. Cancer Res 74: 2276-2280
    • (1994) Cancer Res , vol.74 , pp. 2276-2280
    • Duffy, M.J.1    Reilly, D.2    McDermott, E.3    O'Higgins, N.4    Fennelly, J.J.5    Andreasen, P.A.6
  • 14
    • 0029065722 scopus 로고
    • Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
    • Duggan C, Maguire T, McDermott E, O'Higgins N, Fennelly JJ and Duffy MJ (1995) Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer. Int J Cancer 61: 597-600
    • (1995) Int J Cancer , vol.61 , pp. 597-600
    • Duggan, C.1    Maguire, T.2    McDermott, E.3    O'Higgins, N.4    Fennelly, J.J.5    Duffy, M.J.6
  • 17
    • 0029021196 scopus 로고
    • Urokinase-type plasminogen activator and its inhibitor PAI-1: Predictors of poor response to tamoxifen therapy in recurrent breast cancer
    • Foekens JA, Look MP, Peters HA, van-Putten WL, Portengen H and Klijn JG (1995) Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer. J Natl Cancer Inst 87: 751-756
    • (1995) J Natl Cancer Inst , vol.87 , pp. 751-756
    • Foekens, J.A.1    Look, M.P.2    Peters, H.A.3    Van-Putten, W.L.4    Portengen, H.5    Klijn, J.G.6
  • 21
    • 0027223048 scopus 로고
    • High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis
    • Grundahl-Hansen J, Christensen IJ, Rosenquist C, Brunner N, Mouridsen HT, Dano K and Blichert-Toft M (1993) High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis. Cancer Res 53: 2513-2521
    • (1993) Cancer Res , vol.53 , pp. 2513-2521
    • Grundahl-Hansen, J.1    Christensen, I.J.2    Rosenquist, C.3    Brunner, N.4    Mouridsen, H.T.5    Dano, K.6    Blichert-Toft, M.7
  • 23
    • 0028885643 scopus 로고
    • Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer
    • Heiss MM, Allgayer H, Gruetzner KU, Funke I, Babic R, Jauch KW and Schildberg FW (1995a) Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer. Nature Med 1: 1035-1039
    • (1995) Nature Med , vol.1 , pp. 1035-1039
    • Heiss, M.M.1    Allgayer, H.2    Gruetzner, K.U.3    Funke, I.4    Babic, R.5    Jauch, K.W.6    Schildberg, F.W.7
  • 24
    • 0029097254 scopus 로고
    • Tumor-associated proteolysis and prognosis: New functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system
    • Heiss MM, Babic R, Allgayer H, Gruetzner KU, Jauch KW, Loehrs U and Schildberg FW (1995b) Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system. J Clin Oncol 13: 2084-2093
    • (1995) J Clin Oncol , vol.13 , pp. 2084-2093
    • Heiss, M.M.1    Babic, R.2    Allgayer, H.3    Gruetzner, K.U.4    Jauch, K.W.5    Loehrs, U.6    Schildberg, F.W.7
  • 25
    • 0026766968 scopus 로고
    • Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells
    • Henderson BR, Tansey WP, Phillips SM, Ramshaw IA and Kefford RF (1992) Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells. Cancer Res 52: 2489-2496
    • (1992) Cancer Res , vol.52 , pp. 2489-2496
    • Henderson, B.R.1    Tansey, W.P.2    Phillips, S.M.3    Ramshaw, I.A.4    Kefford, R.F.5
  • 27
    • 0027082979 scopus 로고
    • Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer
    • Jänicke F, Schmitt M, Pache L, Ulm K, Harbeck N, Höfler H and Graeff H (1993) Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer. Breast Cancer Res Treat 24: 195-208
    • (1993) Breast Cancer Res Treat , vol.24 , pp. 195-208
    • Jänicke, F.1    Schmitt, M.2    Pache, L.3    Ulm, K.4    Harbeck, N.5    Höfler, H.6    Graeff, H.7
  • 28
    • 0019214244 scopus 로고
    • A new trephine for closed bone marrow biopsy
    • Jamshidi K, Swaim WR and Raisz G (1980) A new trephine for closed bone marrow biopsy. Acta Haemat 64: 216
    • (1980) Acta Haemat , vol.64 , pp. 216
    • Jamshidi, K.1    Swaim, W.R.2    Raisz, G.3
  • 29
    • 0001677302 scopus 로고
    • Monoclonal antibodies reactive with tumor-associated epitopes of breast mucin glycoproteins
    • Kaul S, Windecker S and Bastert G (1989) Monoclonal antibodies reactive with tumor-associated epitopes of breast mucin glycoproteins Proc Am Assoc Cancer Res 30: 349
    • (1989) Proc Am Assoc Cancer Res , vol.30 , pp. 349
    • Kaul, S.1    Windecker, S.2    Bastert, G.3
  • 32
    • 0025376433 scopus 로고
    • Biochemical and biological aspects of the plasminogen activator system
    • Mayer M (1990) Biochemical and biological aspects of the plasminogen activator system. Clin Biochem 23: 197-211
    • (1990) Clin Biochem , vol.23 , pp. 197-211
    • Mayer, M.1
  • 34
    • 0023797050 scopus 로고
    • Relationship of membrane-bound tissue type and urokinase type-plasminogen activators in human breast cancers to estrogen and epidermal growth factor receptors
    • Needham GK, Nicholson S, Angus B, Farndon JR and Harris AL (1988) Relationship of membrane-bound tissue type and urokinase type-plasminogen activators in human breast cancers to estrogen and epidermal growth factor receptors. Cancer Res 48: 6603-6607
    • (1988) Cancer Res , vol.48 , pp. 6603-6607
    • Needham, G.K.1    Nicholson, S.2    Angus, B.3    Farndon, J.R.4    Harris, A.L.5
  • 36
    • 0025797735 scopus 로고
    • Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow
    • Osborne MP, Wong GY, Asina S, Old LJ, Cote RJ and Rosen PP (1991) Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow. Cancer Res 51: 2706-2709
    • (1991) Cancer Res , vol.51 , pp. 2706-2709
    • Osborne, M.P.1    Wong, G.Y.2    Asina, S.3    Old, L.J.4    Cote, R.J.5    Rosen, P.P.6
  • 37
    • 0025968060 scopus 로고
    • Inhibition of urokinase-type plasminogen activator by antibodies: The effect on dissemination of a human tumor in the nude mouse
    • Ossowski L, Russo-Payne H and Wilson EL (1991) Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse. Cancer Res 51: 274-281
    • (1991) Cancer Res , vol.51 , pp. 274-281
    • Ossowski, L.1    Russo-Payne, H.2    Wilson, E.L.3
  • 39
    • 0028070859 scopus 로고
    • Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue
    • Pedersen H, Brünner N, Francis D, Osterlind K, Ronne E, Hausen HH, Dano K and Grondahl-Hansen J (1994) Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue. Cancer Res 54: 4671-4675
    • (1994) Cancer Res , vol.54 , pp. 4671-4675
    • Pedersen, H.1    Brünner, N.2    Francis, D.3    Osterlind, K.4    Ronne, E.5    Hausen, H.H.6    Dano, K.7    Grondahl-Hansen, J.8
  • 40
    • 0027215058 scopus 로고
    • Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma
    • Pyke C, Graem N, Ralfkiaer E, Ronne E, Hoyer-Hansen G, Brunner N and Dano K (1993) Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma. Cancer Res 53: 1911-1915
    • (1993) Cancer Res , vol.53 , pp. 1911-1915
    • Pyke, C.1    Graem, N.2    Ralfkiaer, E.3    Ronne, E.4    Hoyer-Hansen, G.5    Brunner, N.6    Dano, K.7
  • 42
    • 0024548766 scopus 로고
    • A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma
    • Rosen PR, Groshen S, Saigo PE, Kinne DW and Hellman S (1989) A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma. J Clin Oncol 7: 355-366
    • (1989) J Clin Oncol , vol.7 , pp. 355-366
    • Rosen, P.R.1    Groshen, S.2    Saigo, P.E.3    Kinne, D.W.4    Hellman, S.5
  • 44
    • 0025526239 scopus 로고
    • Tumor-associated fibrinolysis: The prognostic relevance of plasminogen activators uPA and tPA in human breast cancer
    • Schmitt M, Jänicke F and Graeff H (1990) Tumor-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer. Blood Coagul Fibrinolysis 1: 695-702
    • (1990) Blood Coagul Fibrinolysis , vol.1 , pp. 695-702
    • Schmitt, M.1    Jänicke, F.2    Graeff, H.3
  • 46
    • 0024294979 scopus 로고
    • Micrometastases in bone marrow in patients with breast cancer
    • Untch M, Harbeck N and Eiermann W (1988) Micrometastases in bone marrow in patients with breast cancer (letter). Br Med J 296: 290
    • (1988) Br Med J , vol.296 , pp. 290
    • Untch, M.1    Harbeck, N.2    Eiermann, W.3
  • 47
    • 8544243581 scopus 로고
    • Biochemical characterization of the mucin like tumor associated antigen TAG-12
    • Werner M, Kaul S and Bastert G (1988) Biochemical characterization of the mucin like tumor associated antigen TAG-12. J Cancer Res Clin Oncol 114: 59
    • (1988) J Cancer Res Clin Oncol , vol.114 , pp. 59
    • Werner, M.1    Kaul, S.2    Bastert, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.