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Volumn 77, Issue 6, 1996, Pages 1079-1088

Combined overexpression of urokinase, urokinase receptor, and plasminogen activator inhibitor-1 is associated with breast cancer progression: An immunohistochemical comparison of normal, benign, and malignant breast tissues

Author keywords

Breast cancer; Neoplasm progression; Urokinase; Urokinase receptor

Indexed keywords

AVIDIN; BIOTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; UROKINASE RECEPTOR;

EID: 0029968743     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19960315)77:6<1079::AID-CNCR12>3.0.CO;2-Z     Document Type: Article
Times cited : (119)

References (41)
  • 2
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991; 64:327-36.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2
  • 3
    • 0025945850 scopus 로고
    • Direct plasminogen activation at the surface of normal and malignant cells
    • Pollanen J, Stephens RW, Vaheri A. Direct plasminogen activation at the surface of normal and malignant cells. Adv Cancer Res 1991;57:273-328.
    • (1991) Adv Cancer Res , vol.57 , pp. 273-328
    • Pollanen, J.1    Stephens, R.W.2    Vaheri, A.3
  • 4
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Pysiol Rev 1991;73:161-95.
    • (1991) Pysiol Rev , vol.73 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 5
    • 0024309860 scopus 로고
    • Growth factors in the regulation of pericellular proteolysis: A review
    • Laiho M, Keski-Oja J. Growth factors in the regulation of pericellular proteolysis: a review. Cancer Res 1989;49:2533-53.
    • (1989) Cancer Res , vol.49 , pp. 2533-2553
    • Laiho, M.1    Keski-Oja, J.2
  • 6
    • 0023197175 scopus 로고
    • Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors
    • Blasi F, Vassalli JD, Dano K. Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors. J Cell Biol 1987;104:801-4.
    • (1987) J Cell Biol , vol.104 , pp. 801-804
    • Blasi, F.1    Vassalli, J.D.2    Dano, K.3
  • 7
    • 0027550662 scopus 로고
    • Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness
    • Blasi F. Urokinase and urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness. Bioessays 1993;15:105-11.
    • (1993) Bioessays , vol.15 , pp. 105-111
    • Blasi, F.1
  • 8
    • 0023025270 scopus 로고
    • The plasminogen system and cell surface: Evidence for plasminogen and urokinase receptors on the same cell type
    • Plow EF, Freaney DE, Plescia J, Miles LA. The plasminogen system and cell surface: evidence for plasminogen and urokinase receptors on the same cell type. J Cell Biol 1993;103:2411-20.
    • (1993) J Cell Biol , vol.103 , pp. 2411-2420
    • Plow, E.F.1    Freaney, D.E.2    Plescia, J.3    Miles, L.A.4
  • 9
    • 0024238269 scopus 로고
    • In vivo invasion of modified chorioallantoic membrane by tumor cells: The role of cell surface bound urokinase
    • Ossowski L. In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface bound urokinase. J Cell Biol 1988;107:2437-45.
    • (1988) J Cell Biol , vol.107 , pp. 2437-2445
    • Ossowski, L.1
  • 10
    • 0026341460 scopus 로고
    • In vivo paracrine interaction between urokinase and its receptor: Effect on tumor cell invasion
    • Ossowski L, Clunie G, Masucci MT, Blasi F. In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol 1991;115:1107-12.
    • (1991) J Cell Biol , vol.115 , pp. 1107-1112
    • Ossowski, L.1    Clunie, G.2    Masucci, M.T.3    Blasi, F.4
  • 13
    • 0028338844 scopus 로고
    • Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro
    • Stahl A, Mueller BM. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res 1994;54:3066-71.
    • (1994) Cancer Res , vol.54 , pp. 3066-3071
    • Stahl, A.1    Mueller, B.M.2
  • 14
    • 0027202040 scopus 로고
    • Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line
    • Kariko K, Kuo A, Boyd D, Okada SS, Cines DB, Barnathan ES. Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. Cancer Res 1993;53:3109-17.
    • (1993) Cancer Res , vol.53 , pp. 3109-3117
    • Kariko, K.1    Kuo, A.2    Boyd, D.3    Okada, S.S.4    Cines, D.B.5    Barnathan, E.S.6
  • 15
    • 0025867052 scopus 로고
    • Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells
    • Cohen RL, Xi XP, Crowley CW, Lucas BK, Levinson AD, Shuman MA. Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells. Blood 1991;78:479-87.
    • (1991) Blood , vol.78 , pp. 479-487
    • Cohen, R.L.1    Xi, X.P.2    Crowley, C.W.3    Lucas, B.K.4    Levinson, A.D.5    Shuman, M.A.6
  • 16
    • 0025976287 scopus 로고
    • Occurrence of components of fibrinolysis pathways in situ in neoplastic and nonneoplastic human breast tissue
    • Costantini V, Zacharski LR, Memoli VA, Kudryk BJ, Rousseau SM, Stump DC. Occurrence of components of fibrinolysis pathways in situ in neoplastic and nonneoplastic human breast tissue. Cancer Res 1991;51:354-8.
    • (1991) Cancer Res , vol.51 , pp. 354-358
    • Costantini, V.1    Zacharski, L.R.2    Memoli, V.A.3    Kudryk, B.J.4    Rousseau, S.M.5    Stump, D.C.6
  • 17
    • 0027215058 scopus 로고
    • Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma
    • Pyke C, Graem N, Ralfkiaer N, Hoeyer-Hansen G, Brunner N, Dano K. Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma. Cancer Res 1993;53:1911-5.
    • (1993) Cancer Res , vol.53 , pp. 1911-1915
    • Pyke, C.1    Graem, N.2    Ralfkiaer, N.3    Hoeyer-Hansen, G.4    Brunner, N.5    Dano, K.6
  • 18
    • 0027172158 scopus 로고
    • Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels
    • Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, et al. Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: comparison with urokinase levels. Cancer Res 1993;53:3198-206.
    • (1993) Cancer Res , vol.53 , pp. 3198-3206
    • Del Vecchio, S.1    Stoppelli, M.P.2    Carriero, M.V.3    Fonti, R.4    Massa, O.5    Li, P.Y.6
  • 19
    • 0028347646 scopus 로고
    • The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue
    • Bianchi E, Cohen RL, Thor AT, Todd III RF, Mizukami IF, Lawrence DA, et al. The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue. Cancer Res 1994;54:861-6.
    • (1994) Cancer Res , vol.54 , pp. 861-866
    • Bianchi, E.1    Cohen, R.L.2    Thor, A.T.3    Todd III, R.F.4    Mizukami, I.F.5    Lawrence, D.A.6
  • 20
    • 0027361935 scopus 로고
    • Expression and localization of elements of the plasminogen activation system in benign breast disease and in breast cancers
    • Jankun J, Merrick HW, Goldblatt PJ. Expression and localization of elements of the plasminogen activation system in benign breast disease and in breast cancers. J Cell Biochem 1993;53:135-44.
    • (1993) J Cell Biochem , vol.53 , pp. 135-144
    • Jankun, J.1    Merrick, H.W.2    Goldblatt, P.J.3
  • 21
    • 0026662503 scopus 로고
    • Flow cytofluorometry analysis of the urokinase receptor (uPAR) on tumor cells by fluorescent uPA ligand or monoclonal antibody 3936
    • Chucholowski N, Schmitt M, Rettenberger P, Schuren E, Moniwa N, Groetzki L, et al. Flow cytofluorometry analysis of the urokinase receptor (uPAR) on tumor cells by fluorescent uPA ligand or monoclonal antibody 3936. Fibrinolysis 1992;6(4 Suppl):95-102.
    • (1992) Fibrinolysis , vol.6 , Issue.4 SUPPL. , pp. 95-102
    • Chucholowski, N.1    Schmitt, M.2    Rettenberger, P.3    Schuren, E.4    Moniwa, N.5    Groetzki, L.6
  • 22
    • 0025845425 scopus 로고
    • Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA)
    • Kobayashi H, Schmitt M, Goretzki L, Chucholowski N, Calvete J, Kramer M, et al. Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA). J Biol Chem 1991;266:5147-52.
    • (1991) J Biol Chem , vol.266 , pp. 5147-5152
    • Kobayashi, H.1    Schmitt, M.2    Goretzki, L.3    Chucholowski, N.4    Calvete, J.5    Kramer, M.6
  • 23
    • 0028363578 scopus 로고
    • Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression
    • de Vries TJ, Quax PHA, Denijin M, Verrijp KN, Verheijen JA, Verspaget HW, et al. Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression. Am J Pathol 1994;144:70-81.
    • (1994) Am J Pathol , vol.144 , pp. 70-81
    • De Vries, T.J.1    Quax, P.H.A.2    Denijin, M.3    Verrijp, K.N.4    Verheijen, J.A.5    Verspaget, H.W.6
  • 25
    • 0023683287 scopus 로고
    • The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis
    • Bacus S, Flowers JL, Press MF, Bacus JW, McCarty K. The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis. Am J Clin Pathol 1988;90:233-9.
    • (1988) Am J Clin Pathol , vol.90 , pp. 233-239
    • Bacus, S.1    Flowers, J.L.2    Press, M.F.3    Bacus, J.W.4    McCarty, K.5
  • 27
    • 3643062550 scopus 로고
    • Functional and immunological evaluation of fibrinolysis pathway components in extracts of benign and malignant breast tissues: A comparison between cytosolic and membrane-bound reactants
    • Costantini V, Cazzato AO, Pasqualini ME, DeMonte P, Mariotti M, DeVeglia R, et al. Functional and immunological evaluation of fibrinolysis pathway components in extracts of benign and malignant breast tissues: a comparison between cytosolic and membrane-bound reactants [abstract]. Thromb Haemost 1995;73:1461.
    • (1995) Thromb Haemost , vol.73 , pp. 1461
    • Costantini, V.1    Cazzato, A.O.2    Pasqualini, M.E.3    Demonte, P.4    Mariotti, M.5    DeVeglia, R.6
  • 28
    • 0027313380 scopus 로고
    • Comparative localization of receptors for plasmin and for urokinase on MCF7 cells
    • Zhang S, Laurent M, Lopez-Alemany R, Mazar A, Henkin J, Ronne E, et al. Comparative localization of receptors for plasmin and for urokinase on MCF7 cells. Exp Cell Res 1993;207:290-9.
    • (1993) Exp Cell Res , vol.207 , pp. 290-299
    • Zhang, S.1    Laurent, M.2    Lopez-Alemany, R.3    Mazar, A.4    Henkin, J.5    Ronne, E.6
  • 31
    • 0021222137 scopus 로고
    • Characterization of plasminogen activators from normal human breast and colon and from breast and colon carcinomas
    • Tissot JD, Hauert J, Bachmann F. Characterization of plasminogen activators from normal human breast and colon and from breast and colon carcinomas. Int J Cancer 1984;34:295-302.
    • (1984) Int J Cancer , vol.34 , pp. 295-302
    • Tissot, J.D.1    Hauert, J.2    Bachmann, F.3
  • 32
    • 0026061569 scopus 로고
    • Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas
    • Pyke C, Kristensen P, Ralfkiaer E, Grondahl-Hansen J, Eriksen J, Blasi F, et al. Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. Am J Pathol 1991;138:111-7.
    • (1991) Am J Pathol , vol.138 , pp. 111-117
    • Pyke, C.1    Kristensen, P.2    Ralfkiaer, E.3    Grondahl-Hansen, J.4    Eriksen, J.5    Blasi, F.6
  • 33
  • 34
    • 0025127815 scopus 로고
    • Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer
    • Janicke F, Schmitt M, Hafter R, Hollrieder A, Babic R, Ulm K, et al. Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer. Fibrinolysis 1990;4:69-78.
    • (1990) Fibrinolysis , vol.4 , pp. 69-78
    • Janicke, F.1    Schmitt, M.2    Hafter, R.3    Hollrieder, A.4    Babic, R.5    Ulm, K.6
  • 35
    • 0018757458 scopus 로고
    • Mammary plasminogen activator: Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue
    • Ossowski L, Biegel D, Reich E. Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Cell 1979;16:929-40.
    • (1979) Cell , vol.16 , pp. 929-940
    • Ossowski, L.1    Biegel, D.2    Reich, E.3
  • 36
    • 0025995880 scopus 로고
    • Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer
    • Janicke F, Schmitt M, Graeff H. Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer. Semin Thromb Hemost 1991;17:303-12.
    • (1991) Semin Thromb Hemost , vol.17 , pp. 303-312
    • Janicke, F.1    Schmitt, M.2    Graeff, H.3
  • 37
    • 0027082979 scopus 로고
    • Urokinase CuPA and its inhibitor PAI-1 are strong, independent prognostic factors in node-negative breast cancer
    • Janicke F, Schmitt M, Fache L, Ulm K, Harbeck N, Hofler H, et al. Urokinase CuPA) and its inhibitor PAI-1 are strong, independent prognostic factors in node-negative breast cancer. Breast Cancer Res Treat 1993;24:195-208.
    • (1993) Breast Cancer Res Treat , vol.24 , pp. 195-208
    • Janicke, F.1    Schmitt, M.2    Fache, L.3    Ulm, K.4    Harbeck, N.5    Hofler, H.6
  • 38
    • 0027223048 scopus 로고
    • High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis
    • Grondahl-Hansen J, Christensen IJ, Rosenquist C, Brunner N, Mouridsen HT, Dano K, et al. High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis. Cancer Res 1993;53:2513-21.
    • (1993) Cancer Res , vol.53 , pp. 2513-2521
    • Grondahl-Hansen, J.1    Christensen, I.J.2    Rosenquist, C.3    Brunner, N.4    Mouridsen, H.T.5    Dano, K.6
  • 39
    • 0028127825 scopus 로고
    • Prognostic value of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas
    • Bouchet C, Spyratos F, Martin PM, Hacene K, Gentile A, Oglobine J. Prognostic value of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas. Br J Cancer 1994;69:398-405.
    • (1994) Br J Cancer , vol.69 , pp. 398-405
    • Bouchet, C.1    Spyratos, F.2    Martin, P.M.3    Hacene, K.4    Gentile, A.5    Oglobine, J.6
  • 41
    • 2042503759 scopus 로고
    • Functional inhibition of endogenously produced urokinase decreases cell proliferation in human melanoma cell line
    • Kirchlheimer JC, Wojta Christ G, Binder BR. Functional inhibition of endogenously produced urokinase decreases cell proliferation in human melanoma cell line. Proc Natl Acad Sci U S A 1989;86:5424-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5424-5428
    • Kirchlheimer, J.C.1    Wojta Christ, G.2    Binder, B.R.3


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