Neuropathic Itch

ITCH: Mechanisms and Treatment

Volumn , Issue , 2014, Pages 89-119

  Oaklander, Anne Louise ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85137453113     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b16573-11     Document Type: Chapter

References (164)

1. Abbott, L. G. (1998). Neuropathic pruritus. Australas J. Dermatol. 39(3): 198-199.
2. Ahmed, M. A., Mohamed, S. A., and Sayed, D. (2011). Long-term antalgic effects of repetitive transcranial magnetic stimulation of motor cortex and serum beta-endorphin in patients with phantom pain. Neurol. Res. 33(9): 953-958.
3. Amato, A. A., and Oaklander, A. L. (2004). Case records of the Massachusetts General Hospital. Case 16-2004. A 76-year-old woman with pain and numbness in the legs and feet. New Engl. J. Med. 350(21): 2181-2189.
4. Andreev, V. C., and Petkov, I. (1975). Skin manifestations associated with tumours of the brain. Br. J. Dermatol. 92(6): 675-678.
5. Asada, H., Yamaguchi, Y., Tsunoda, S., and Fukuda, Y. (1996). Relation of abnormal burst activity of spinal neurons to the recurrence of autotomy in rats. Neurosci. Lett. 213(2): 99-102.
6. Basbaum, A. I., and Wall, P. D. (1976). Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: The appearance of responding cells in a previously non-responsive region. Brain Res. 116(2): 181-204.
7. Becker, S. W. (1925). Dermatitis in association with disease or injury of the peripheral nerves. Arch. Derm. Syphilol. 12: 235.
8. Bhushan, M., Parry, E. J., and Telfer, N. R. (1999). Trigeminal trophic syndrome: Successful treatment with carbamazepine. Br. J. Dermatol. 141(4): 758-759.
9. Blumenkopf, B., and Lipman, J. J. (1991). Studies in autotomy: Its pathophysiology and use-fulness as a model of chronic pain [see comments]. Pain. 45(2): 203-209.
10. Brewer, K. L., Lee, J. W., Downs, H., Oaklander, A. L., and Yezierski, R. P. (2008). Dermatomal scratching after intramedullary quisqualate injection: Correlation with cutaneous dener-vation. J. Pain. 9(11): 999-1005.
11. Briner, R. P., Carlton, S. M., Coggeshall, R. E., and Chung, K. S. (1988). Evidence for unmy-elinated sensory fibres in the posterior columns in man. Brain 111(Pt 5): 999-1007.
12. Campbell, J. N., and Long, D. M. (1976). Peripheral nerve stimulation in the treatment of intractable pain. J. Neurosurg. 45(6): 692-699.
13. Canavero, S., Bonicalzi, V., and Massa-Micon, B. (1997). Central neurogenic pruritus: A lit-erature review. Acta Neurol. Belg. 97(4): 244-247.
14. Challapalli, V., Tremont-Lukats, I. W., McNicol, E. D., Lau, J., and Carr, D. B. (2005). Systemic administration of local anesthetic agents to relieve neuropathic pain. Cochrane Database Syst. Rev. (4) CD003345.
15. Chan, B. L., Witt, R., Charrow, A. P., Magee, A., Howard, R., Pasquina, P. F., Heilman, K. M., and Tsao, J. W. (2007). Mirror therapy for phantom limb pain. New Engl. J. Med. 357(21): 2206-2207.
16. Chandler, R. L. (1961). Encephalopathy in mice produced by inoculation with scrapie brain material. Lancet. 1(7191): 1378-1379.
17. Cliff, I. S., and Demis, D. J. (1967). Giant ulcer of the face following surgery for trigeminal neuralgia. Arch. Intern. Med. 119(2): 218-222.
18. Cohen, O. S., Chapman, J., Lee, H., Nitsan, Z., Appel, S., Hoffman, C., Rosenmann, H., Korczyn, A. D., and Prohovnik, I. (2011). Pruritus in familial Creutzfeldt-Jakob disease: A common symptom associated with central nervous system pathology. J. Neurol. 258(1): 89-95.
19. Cohen-Adad, J., Zhao, W., Wald, L. L., and Oaklander, A. L. (2012). 7T MRI of spinal cord injury. Neurology. 79(22): 2217.
20. Curtis, A. R., Oaklander, A. L., Johnson, A., and Yosipovitch, G. (2012). Trigeminal trophic syndrome from stroke: An under-recognized central neuropathic itch syndrome. Am. J. Clin. Dermatol. 13(2): 125-128.
21. Cushing, H. (1920). The major trigeminal neuralgias and their surgical treatment based on experiences with 332 Gasserian operations. Am. J. Med. Sci. 160: 157-184.
22. Davidson, S., Zhang, X., Khasabov, S. G., Moser, H. R., Honda, C. N., Simone, D. A., and Giesler, G. J., Jr. (2012). Pruriceptive spinothalamic tract neurons: Physiological proper-ties and projection targets in the primate. J. Neurophysiol. 108(6): 1711-1723.
23. Dey, D. D., Landrum, O., and Oaklander, A. L. (2005). Central neuropathic itch from spinal-cord cavernous hemangioma: A human case, a possible animal model, and hypotheses about pathogenesis. Pain 113(1-2): 233-237.
24. Dick, M. T., and Gonyea, E. (1990). Trigeminal neurotrophic ulceration with Wallenberg’s syndrome. Neurology. 40(10): 1634-1635.
25. Dostrovsky, J. O. (1999). Immediate and long-term plasticity in human somatosensory thala-mus and its involvement in phantom limbs. Pain Suppl. 6: S37-S43.
26. Drzezga, A., Darsow, U., Treede, R. D., Siebner, H., Frisch, M., Munz, F., Weilke, F., Ring, J., Schwaiger, M., and Bartenstein, P. (2001). Central activation by histamine-induced itch: Analogies to pain processing: A correlational analysis of O-15 H2O positron emission tomography studies. Pain 92(1-2): 295-305.
27. Duckrow, R. B., and Taub, A. (1977). The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy. Exp. Neurol. 54(1): 33-41.
28. Duke, E. E. (1983). Clinical experience with pimozide: Emphasis on its use in postherpetic neuralgia. J. Am. Acad. Dermatol. 8(6): 845-850.
29. Eisenberg, E., Barmeir, E., and Bergman, R. (1997). Notalgia paresthetica associated with nerve root impingement. J. Am. Acad. Dermatol. 37(6): 998-1000.
30. Elkersh, M. A., Simopoulos, T. T., Malik, A. B., Cho, E. H., and Bajwa, Z. H. (2003). Epidural clonidine relieves intractable neuropathic itch associated with herpes zoster-related pain. Reg. Anesth. Pain Med. 28(4): 344-346.
31. Elsone, L., Townsend, T., Mutch, K., Das, K., Boggild, M., Nurmikko, T., and Jacob, A. (2012). Neuropathic pruritus (itch) in neuromyelitis optica. Mult. Scler. 19(4): 475-479.
32. England, J. D., Gronseth, G. S., Franklin, G., Carter, G. T., Kinsella, L. J., Cohen, J. A., Asbury, A. K. et al. (2009). Practice parameter: Evaluation of distal symmetric poly-neuropathy: Role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology. 72(2): 177-184.
33. Ferrini, R., and Paice, J. (2004). How to initiate and monitor infusional lidocaine for severe and/or neuropathic pain. J. Support Oncol. 2: 90-94.
34. Finlay, A. Y. (1979). Trigeminal trophic syndrome. Arch. Dermatol. 115(9): 1118.
35. Fitzek, S., Baumgartner, U., Marx, J., Joachimski, F., Axer, H., Witte, O. W., and Fitzek, C. (2006). Pain and itch in Wallenberg’s syndrome: Anatomical-functional correlations. Suppl. Clin. Neurophysiol. 58: 187-194.
36. Fleischer, A. B., Meade, T. J., and Fleischer, A. B. (2011). Notalgia paresthetica: Successful treatment with exercises. Acta Derm. Venereol. 91(3): 356-357.
37. Fleury, V., Wayte, J., and Kiley, M. (2008). Topiramate-induced delusional parasitosis. J. Clin. Neurosci. 15(5): 597-599.
38. Freeman, R., Chase, K. P., and Risk, M. R. (2003). Quantitative sensory testing cannot dif-ferentiate simulated sensory loss from sensory neuropathy. Neurology. 60(3): 465-470.
39. Gazerani, P., Pedersen, N. S., Drewes, A. M., and Arendt-Nielsen, L. (2009). Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin. Br. J. Dermatol. 161(4): 737-745, doi:10.1111/j.1365-2133.2009.09305.x.
40. Georgiadis, A. L., Yamamoto, Y., Kwan, E. S., Pessin, M. S., and Caplan, L. R. (1999). Anatomy of sensory findings in patients with posterior cerebral artery territory infarc-tion. Arch. Neurol. 56: 835-838.
41. Gooding, S. M. D., Canter, P. H., Coelho, H. F., Boddy, K., and Ernst, E. (2010). Systematic review of topical capsaicin in the treatment of pruritus. Int. J. Dermatol. 49(8): 858-865.
42. Goodkin, R., Wingard, E., and Bernhard, J. D. (2003). Brachioradial pruritus: Cervical spine disease and neurogenic/neuropathic pruritus. J. Am. Acad. Dermatol. 48(4): 521-524.
43. Goulden, V., Toomey, P. J., and Highet, A. S. (1998). Successful treatment of notalgia par-esthetica with a paravertebral local anesthetic block. J. Am. Acad. Dermatol. 38(1): 114-116.
44. Hagermark, O., Hokfelt, T., and Pernow, B. (1978). Flare and itch induced by substance P in human skin. J. Invest. Dermatol. 71(4): 233-235.
45. Han, L., Ma, C., Liu, Q., Weng, H. J., Cui, Y., Tang, Z., Kim, Y. et al. (2012). A subpopulation of nociceptors specifically linked to itch. Nat. Neurosci. 16(2): 174-182.
46. Harper, N. (1985). Trigeminal trophic syndrome. Postgrad. Med. J. 61(715): 449-451.
47. Harris, W. (1940). An analysis of 1, 433 cases of paroxysmal trigeminal neuralgia (Trigeminal-Tic) and the end-results of gasserian alcohol injection. Brain. 63(3): 209-224.
48. Hartog, C. S., Kohl, M., and Reinhart, K. (2011). A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: Safety not adequately addressed. Anesth. Analg. 112(3): 635-645.
49. Henderson, W. R. (1967). Trigeminal neuralgia: The pain and its treatment. Br. Med. J. 1: 7-13.
50. Howell, J. B. (1962). Neurotrophic changes in the trigeminal territory. Arch. Dermatol. 86: 442-449.
51. Hsieh, J. C., Hagermark, O., Stahle-Backdahl, M., Ericson, K., Eriksson, L., Stone-Elander, S., and Ingvar, M. (1994). Urge to scratch represented in the human cerebral cortex dur-ing itch. J. Neurophysiol. 72(6): 3004-3008.
52. Jaeger, H. (1950). Un type noveau d’ulcere neurotrophique de l’aile du nez apres neurotomie retrogasserienne. Dermatologica 100(4-6): 201-206.
53. Jastreboff, P. J. (1990). Phantom auditory perception (tinnitus): Mechanisms of generation and perception. Neurosci. Res. 8: 221-254.
54. Jeannet, P. Y., Watts, G. D., Bird, T. D., and Chance, P. F. (2001). Craniofacial and cutaneous findings expand the phenotype of hereditary neuralgic amyotrophy. Neurology. 57(11): 1963-1968.
55. Jefferson, G., and Schorstein, J. (1955). Injuries of the trigeminal nerve, its ganglion and its divisions. Br. J. Surg. 42(176): 561-581.
56. Jensen, T. S., Baron, R., Haanpää, M., Kalso, E., Loeser, J. D., Rice, A. S. C., and Treede, R. D. (2011). A new definition of neuropathic pain. Pain. 152(10): 2204-2205.
57. Jensen, T. S., Baron, R., Haanpää, M., Kalso, E., Loeser, J. D., Rice, A. S. C., and Treede, R. D. (2012). Response to letters by Oaklander et al. and Horowitz. Pain. 153(4): 935-936.
58. Jinks, S. L., and Carstens, E. (2000). Superficial dorsal horn neurons identified by intracutaneous histamine: Chemonociceptive responses and modulation by morphine. J. Neurophysiol. 84(2): 616-627.
59. Johnson, R. E., Kanigsberg, N. D., and Jimenez, C. L. (2000). Localized pruritus: A presenting symptom of a spinal cord tumor in a child with features of neurofibromatosis. J. Am. Acad. Dermatol. 43(5 Pt 2): 958-961.
60. Kamann, S., Flaig, M. J., and Korting, H. C. (2007). Hydroxyethyl starch-induced itch: Relevance of light microscopic analysis of semi-thin sections and electron microscopy. J. Dtsch. Dermatol. Ges. 5(3): 204-208.
61. Karnosh, U., and Scherb, R. E. (1940). Trophic lesions in the distribution of the trigeminal nerve. JAMA 115: 2144-2147.
62. Kavak, A., and Dosoglu, M. (2002). Can a spinal cord tumor cause brachioradial pruritus? J. Am. Acad. Dermatol. 46(3): 437-440.
63. Kavanagh, G. M., and Tidman, M. J. (2012). Botulinum A toxin and brachioradial pruritus. Br. J. Dermatol. 166(5): 1147.
64. Kavanagh, G. M., Tidman, M. J., McLaren, K. M., Goldberg, A., and Benton, E. C. (1996). The trigeminal trophic syndrome: An under-recognized complication. Clin. Exp. Dermatol. 21(4): 299-301.
65. King, C. A., Huff, F. J., and Jorizzo, J. L. (1982). Unilateral neurogenic pruritus: Paroxysmal itching associated with central nervous system lesions. Ann. Intern. Med. 97(2): 222-223.
66. Kinsella, L. J., Carney-Godley, K., and Feldmann, E. (1992). Lichen simplex chronicus as the initial manifestation of intramedullary neoplasm and syringomyelia. Neurosurgery. 30(3): 418-421.
67. Klemm, E., Bepperling, F., Burschka, M. A., and Mosges, R. (2007). Hemodilution therapy with hydroxyethyl starch solution (130/0.4) in unilateral idiopathic sudden sensorineu-ral hearing loss: A dose-finding, double-blind, placebo-controlled, international multi-center trial with 210 patients. Otol. Neurotol. 28(2): 157-170.
68. Knight, G. C. (1954). Herpes simplex and trigeminal neuralgia. Proc. R. Soc. Med. 47: 788-790.
69. Lee, C. C., Kuo, L. T., Wang, C. H., Scaravilli, F., and An, S. F. (2005). Accumulation of prion protein in the peripheral nervous system in human prion diseases. J. Neuropathol. Exp. Neurol. 64(8): 716-721.
70. Leung, A., Donohue, M., Xu, R., Lee, R., Lefaucheur, J. P., Khedr, E. M., Saitoh, Y. et al. (2009). rTMS for suppressing neuropathic pain: A meta-analysis. J. Pain. 10(12): 1205-1216.
71. Levitt, M., Ovelmen-Levitt, J., Rossitch, E., Jr., and Nashold, B. S., Jr. (1992). On the contro-versy of autotomy: A response to L. Kruger. Pain. 51(1): 120-121.
72. Lierman, L. M. (1988). Phantom breast experiences after mastectomy. Oncol. Nurs. Forum. 15(1): 41-44.
73. Lombard, M. C., Nashold, B. S., Jr., Albe-Fessard, D., Salman, N., and Sakr, C. (1979). Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain. Pain. 6(2): 163-174.
74. Loveman, A. B. (1933). An unusual dermatosis following section of the fifth cranial nerve. Arch. Derm. Syphilol. 28: 369-375.
75. Maciejewski, R., and Drop, A. (2002). Neurological symptoms as the result of enlarged dimensions and non-typical course of inferior superficial temporal vein. Folia Morphol. 61(1): 57-60.
76. Macovei, M., Popa, C., Alexianu, M. E., and Vulcan, P. (1991). Neurotrophic trigeminal syn-drome after pontine stroke. Rom. J. Neurol. Psychiatry 29(3-4): 153-158.
77. Maggi, C. A., Borsini, F., Santicioli, P., Geppetti, P., Abelli, L., Evangelista, S., Manzini, S., Theodorsson-Norheim, E., Somma, V., and Amenta, F. (1987). Cutaneous lesions in capsaicin-pretreated rats. A trophic role of capsaicin-sensitive afferents? Naunyn Schmiedebergs Arch. Pharmacol. 336(5): 538-545.
78. Mailis, A. (1996). Compulsive targeted self-injurious behaviour in humans with neuropathic pain: A counterpart of animal autotomy? Four case reports and literature review. Pain. 64(3): 569-578.
79. Massey, E. W. (1984). Unilateral neurogenic pruritus following stroke. Stroke. 15(5): 901-903.
80. Massey, E. W., and Massey, J. M. (1986). Forearm neuropathy and pruritus. South Med. J. 79(10): 1259-1260.
81. Massey, E. W., and Pleet, A. B. (1979). Localized pruritus-notalgia paresthetica. Arch. Dermatol. 115(8): 982-983.
82. Massey, E. W., and Pleet, A. B. (1981). Electromyographic evaluation of notalgia paresthetica. Neurology. 31(5): 642.
83. Matthews, W. (2005). The symptoms and signs of multiple sclerosis. In McAlpine’s Multiple Sclerosis, 4th ed. Philadelphia, PA: Churchill Livingstone, p. 326.
84. Mayer, R. D., and Smith, N. P. (1993). Improvement of trigeminal neurotrophic ulceration with pimozide in a cognitively impaired elderly woman-A case report. Clin. Exp. Dermatol. 18(2): 171-173.
85. McCann, M. E., Waters, P., Goumnerova, L. C., and Berde, C. (2004). Self-mutilation in young children following brachial plexus birth injury. Pain 110(1-2): 123-129.
86. McKenzie, K. G. (1933). Observations on the results of the operative treatment of trigeminal neuralgia. Can. Med. Assoc. J. 22: 492-496.
87. McLean, N. R., and Watson, A. C. (1982). Reconstruction of a defect of the ala nasi follow-ing trigeminal anaesthesia with an innervated forehead flap. Br. J. Plast. Surg. 35(2): 201-203.
88. Meiss, F., Boerner, D., Marsch, W. C., and Fischer, M. (2002). Gabapentin-A promising treatment in glossodynia. Clin. Exp. Dermatol. 27(6): 525-526.
89. Merskey, H., and Bogduk, N. (1994). Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms, 2nd ed. Seattle: IASP Press.
90. Meyer, R. A., Raja, S. N., and Campbell, J. N. (1985). Coupling of action potential activity between unmyelinated fibers in the peripheral nerve of monkey. Science. 227(4683): 184-187.
91. Mochizuki, H., Inui, K., Tanabe, H. C., Akiyama, L. F., Otsuru, N., Yamashiro, K., Sasaki, A., Nakata, H., Sadato, N., and Kakigi, R. (2009). Time course of activity in itch-related brain regions: A combined MEG-MRI study. J. Neurophysiol. 102(5): 2657-2666.
92. Mochizuki, H., Tashiro, M., Kano, M., Sakurada, Y., Itoh, M., and Yanai, K. (2003). Imaging of central itch modulation in the human brain using positron emission tomography. Pain 105(1-2): 339-346.
93. Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O. et al. (1999). Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80(1-2): 67-82.
94. Nakamizo, S., Miyachi, Y., and Kabashima, K. (2010). Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin. Acta Derm. Venereol. 90(6): 654-655.
95. Nguyen, J. P., Nizard, J., Keravel, Y., and Lefaucheur, J. P. (2011). Invasive brain stimulation for the treatment of neuropathic pain. Nat. Rev. Neurol. 7(12): 699-709.
96. Oaklander, A. L., and Belzberg, A. J. (1997). Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia. Brain Res. Mol. Brain Res. 52(1): 162-165.
97. Oaklander, A. L., Bowsher, D., Galer, B. S., Haanpää, M. L., and Jensen, M. P. (2003). Herpes zoster itch: Preliminary epidemiologic data. J. Pain. 4(6): 338-343.
98. Oaklander, A. L., and Brown, J. M. (2004). Unilateral nerve injury produces bilateral loss of distal innervation. Ann. Neurol. 55(5): 639-644.
99. Oaklander, A. L., Cohen, S. P., and Raju, S. V. (2002). Intractable postherpetic itch and cutane-ous deafferentation after facial shingles. Pain 96(1-2): 9-12.
100. Oaklander, A. L., Dey, D., and Landrum, O. (2005). Response to letter by Dr Yezierski and Vierck. Pain. 115(3): 420-421.
101. Oaklander, A. L., Long, D. M., Larvie, M., and Davidson, C. J. (2013). Case Records of the Massachusetts General Hospital: A 77-year-old woman with long-standing unilateral thoracic pain and incontinence. New Engl. J. Med. in press. 36(9): 853-861.
102. Oaklander, A. L., Romans, K., Horasek, S., Stocks, A., Hauer, P., and Meyer, R. A. (1998). Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage. Ann. Neurol. 44(5): 789-795.
103. Oaklander, A. L., Seo, W. K., and Ho Park, M. (2009). Neuropathic pruritus following Wallenberg syndrome. Neurology. 73(19): 1605-1606.
104. Oaklander, A. L., Wilson, P. R., Moskovitz, P. A., Manning, D. C., Lubenow, T., Levine, J. D., Harden, R. N. et al. (2012). Response to “A new definition of neuropathic pain.” Pain. 153(4): 934-935.
105. Ostermann, P. O. (1976). Paroxysmal itching in multiple sclerosis. Br. J. Dermatol. 95(5): 555-558.
106. Pappagallo, M., Oaklander, A. L., Quatrano-Piacentini, A. L., Clark, M. R., and Raja, S. N. (2000). Heterogenous patterns of sensory dysfunction in postherpetic neuralgia suggest multiple pathophysiologic mechanisms. Anesthesiology. 92(3): 691-698.
107. Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M. et al. (2002). A heat-sensitive TRP channel expressed in keratinocytes. Science. 296(5575): 2046-2049.
108. Petrie, L., Heath, B., and Harold, D. (1989). Scrapie: Report of an outbreak and brief review. Can. Vet. J. 30(4): 321-327.
109. Philpott, O. S. (1941). Trophic ulcer complicating operative procedures for the relief of tri-geminal neuralgia. Rocky Mountain Med. J. 38: 626-629.
110. Raison-Peyron, N., Meunier, L., Acevedo, M., and Meynadier, J. (1999). Notalgia paresthetica:Clinical, physiopathological and therapeutic aspects. A study of 12 cases. J. Eur. Acad. Dermatol. Venereol. 12(3): 215-221.
111. Ranoux, D., Attal, N., Morain, F., and Bouhassira, D. (2008). Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain. Ann. Neurol. 64(3): 274-283.
112. Rapin, I., and Ruben, R. J. (1976). Patterns of anomalies in children with malformed ears. Laryngoscope. 86(10): 1469-1502.
113. Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J., Cohen, S., Jung, C., Hu, L. et al. (2010). Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 65(6): 886-898.
114. Rossitch, E., Jr., Abdulhak, M., Ovelmen-Levitt, J., Levitt, M., and Nashold, B. S., Jr. (1993). The expression of deafferentation dysesthesias reduced by dorsal root entry zone lesions in the rat. J. Neurosurg. 78(4): 598-602.
115. Sacks, O. (2012). Hallucinations. New York: Alfred A. Knopf.
116. Sandroni, P. (2002). Central neuropathic itch: a new treatment option? Neurology. 59(5): 778-779.
117. Sarkis, D., Souteyrand, J. P., and Albe-Fessard, D. (1984). Self-stimulation in the ventral teg-mental area suppresses self-mutilation in rats with forelimb deafferentiation. Neurosci. Lett. 44(2): 199-204.
118. Savin, J. A. (1975). Studies of scratching during sleep. Proc. R. Soc. Med. 68(8): 529.
119. Savin, J. A., Adam, K., Oswald, I., and Paterson, W. D. (1990). Pruritus and nocturnal waken-ings. J. Am. Acad. Dermatol. 23(4 Pt 1): 767-768.
120. Savin, J. A., Paterson, W. D., and Oswald, I. (1973). Scratching during sleep. Lancet. 2(7824): 296-297.
121. Savitsky, N., and Elpern, S. P. (1948). Gangrene of face following occlusion of posterior infe-rior cerebellar artery. Arch. Neurol. Psychiatry 60: 388-391.
122. Savk, E., Bolukbasi, O., Akyol, A., and Karaman, G. (2001). Open pilot study on oxcarbaze-pine for the treatment of notalgia paresthetica. J. Am. Acad. Dermatol. 45(4): 630-632.
123. Savk, E., Dikicioglu, E., Culhaci, N., Karaman, G., and Sendur, N. (2002). Immunohistochemical findings in notalgia paresthetica. Dermatology. 204(2): 88-93.
124. Savk, E., and Savk, S. O. (2004). On brachioradial pruritus and notalgia paresthetica. J. Am. Acad. Dermatol. 50(5): 800-801.
125. Savk, O., and Savk, E. (2005). Investigation of spinal pathology in notalgia paresthetica. J. Am. Acad. Dermatol. 52(6): 1085-1087.
126. Schorstein, J. (1943). Erosion of the ala nasi following trigeminal denervation. J. Neurol. Psychiatry 6: 46-51.
127. Schultz, G., and Melzack, R. (1991). The Charles Bonnet syndrome: “Phantom visual images.” Perception 20: 809-825.
128. Scott, C., Perry, M. J., Raven, P. E., Massey, E. J., and Lisney, S. J. (2000). Capsaicin-sensitive afferents are involved in signalling transneuronal effects between cutaneous sensory nerves. Neuroscience. 95(2): 535-541.
129. Shabtai, H., Nisipeanu, P., Chapman, J., and Korczyn, A. D. (1996). Pruritus in Creutzfeldt-Jakob disease. Neurology. 46(4): 940-941.
130. Shapiro, P. E., and Braun, C. W. (1987). Unilateral pruritus after a stroke. Arch. Dermatol. 123(11): 1527-1530.
131. Shir, Y., Ratner, A., and Seltzer, Z. (1997). Diet can modify autotomy behavior in rats follow-ing peripheral neurectomy. Neurosci. Lett. 236: 71-74.
132. Sikand, P., Shimada, S. G., Green, B. G., and LaMotte, R. H. (2011). Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain. 152(11): 2485-2494.
133. Simone, D. A., Nolano, M., Johnson, T., Wendelschafer-Crabb, G., and Kennedy, W. R. (1998). Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: Correlation with sensory function. J. Neurosci. 18(21): 8947-8959.
134. Simone, D. A., Zhang, X., Li, J., Zhang, J. M., Honda, C. N., LaMotte, R. H., and Giesler, G. J., Jr. (2004). Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli. J. Neurophysiol. 91(1): 213-222.
135. Spalletta, G., Piras, F., Alex, R. I., Caltagirone, C., and Fagioli, S. (2012). Fronto-thalamic volumetry markers of somatic delusions and hallucinations in schizophrenia. Psychiatry Res. 202(1): 54-64.
136. Spillane, J. D., and Wells, C. E. C. (1959). Isolated trigeminal neuropathy: A report of 16 cases. Brain 82: 391-426.
137. Springall, D. R., Karanth, S. S., Kirkham, N., Darley, C. R., and Polak, J. M. (1991). Symptoms of notalgia paresthetica may be explained by increased dermal innervation. J. Invest. Dermatol. 97(3): 555-561.
138. Ständer, S., Weisshaar, E., Mettang, T., Szepietowski, J. C., Carstens, E., Ikoma, A., Bergasa, N. V. et al. (2007). Clinical classification of itch: A position paper of the International Forum for the Study of Itch. Acta Derm. Venereol. 87(4): 291-294.
139. Stefaniu, A., Romascanu, G., and Calarasu, R. (1973). Glossopharyngeal neuralgia causing tonsillar autotraumatism. Otorinolaringologie. 18(6): 453-456.
140. Sullivan, M. J., and Drake, M. E., Jr. (1984). Unilateral pruritus and Nocardia brain abscess. Neurology. 34(6): 828-829.
141. Summers, C. G., and MacDonald, J. T. (1988). Paroxysmal facial itch: A presenting sign of childhood brainstem glioma. J. Child Neurol. 3(3): 189-192.
142. Sweet, W. H. (1981). Animal models of chronic pain: their possible validation from human experience with posterior rhizotomy and congenital analgesia (Part I of the second John J. Bonica lecture). Pain. 10(3): 275-295.
143. Thielen, A. M., Vokatch, N., and Borradori, L. (2008). Chronic hemicorporal prurigo related to a posttraumatic Brown-Séquard syndrome. Dermatology. 217(1): 45-47.
144. Thomas, J., Parimalam, S., Selvi, G. T., Augustine, S. M., and Muthuswami, T. C. (1991). Trigeminal trophic syndrome in Hansen’s disease. Int. J. Lepr. Other Mycobact. Dis. 59(3): 479-480.
145. Tseng, S. H., and Lin, S. M. (1998). Substantia nigra lesion suppresses the antagonistic effects of N-methyl-D-aspartate receptor antagonist (MK-801) on the autotomy in the rat. Neurosci. Lett. 255(3): 167-171.
146. van Alfen, N., and van Engelen, B. G. M. (2006). The clinical spectrum of neuralgic amyotro-phy in 246 cases. Brain. 129(2): 438-450.
147. Veien, N. K., and Laurberg, G. (2011). Brachioradial pruritus: A follow-up of 76 patients. Acta Derm. Venereol. 91(2): 183-185.
148. Vuadens, P., Regli, F., Dolivo, M., and Uske, A. (1994). Segmental pruritus and intramedullary vascular malformation. Schweiz. Arch. Neurol. Psychiatr. 145(3): 13-16.
149. Wahlgren, C. F. (1995). Measurement of itch. Semin. Dermatol. 14(4): 277-284.
150. Wall, P. D., Devor, M., Inbal, R., Scadding, J. W., Schonfeld, D., Seltzer, Z., and Tomkiewicz, M. M. (1979). Autotomy following peripheral nerve lesions: Experimental anaesthesia dolorosa. Pain. 7(2): 103-111.
151. Wallenberg, A. (1901). Klinische Beiträge zur Diagnostik acuter Herderkrankungen des ver-längerten Markes und der Brücke. Dtsch. Zeitsch. Nervenheil. 19: 227-248.
152. Wallengren, J., and Bartosik, J. (2010). Botulinum toxin type A for neuropathic itch. Br. J. Dermatol. 163(2): 424-426.
153. Walton, S., and Keczkes, K. (1985). Trigeminal neurotrophic ulceration-A report of four patients. Clin. Exp. Dermatol. 10(5): 485-490.
154. Warren, J. C. (1828). Cases of neuralgia, or painful affections of nerves. Boston Med. Surg. J. 1(1): 1-6.
155. Watson, W. C. (1973). Intravenous lignocaine for relief of intractable itch. Lancet. 1(7796): 211.
156. Weeks, S. R., and Tsao, J. W. (2010). Incorporation of another person’s limb into body image relieves phantom limb pain: A case study. Neurocase. 16(6): 461-465.
157. Westerhof, W., and Bos, J. D. (1983). Trigeminal trophic syndrome: A successful treatment with transcutaneous electrical stimulation. Br. J. Dermatol. 108(5): 601-604.
158. Wolf, J. K. (1971). The Classical Brain Stem Syndromes: Translations of the Original Papers with Notes on the Evolution of Clinical Neuroanatomy. Springfield, IL: Charles C. Thomas.
159. Woolf, C. J., and Wall, P. D. (1982). Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain Res. 242: 77-85.
160. Yamamoto, M., Yabuki, S., Hayabara, T., and Otsuki, S. (1981). Paroxysmal itching in mul-tiple sclerosis: A report of three cases. J. Neurol. Neurosurg. Psychiatry. 44(1): 19-22.
161. Yezierski, R. P., Liu, S., Ruenes, G. L., Kajander, K. J., and Brewer, K. L. (1998). Excitotoxic spinal cord injury: Behavioral and morphological characteristics of a central pain model. Pain. 75(1): 141-155.
162. Zhao, P., Barr, T. P., Hou, Q., Dib-Hajj, S. D., Black, J. A., Albrecht, P. J., Petersen, K. et al. (2008). Voltage-gated sodium channel expression in rat and human epidermal keratino-cytes: Evidence for a role in pain. Pain. 139(1): 90-105.
163. Ziccardi, V. B., Rosenthal, M. S., and Ochs, M. W. (1996). Trigeminal trophic syndrome: A case of maxillofacial self-mutilation. J. Oral Maxillofac. Surg. 54(3): 347-350.
164. Zotova, E. G., and Arezzo, J. C. (2013). Non-invasive evaluation of nerve conduction in small diameter fibers in the rat. Physiol. J. 2013: 254789.