Placental Anatomy and Physiology

Obstetrics: Normal and Problem Pregnancies

Volumn , Issue , 2016, Pages 2-25

  Burton, Graham J ^a   Sibley, Colin P ^b   Jauniaux, Eric R M ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85130663917     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-323-32108-2.00001-9     Document Type: Chapter

References (104)

1. E Jauniaux., B Gulbis., GJ Burton The human first trimester gestational sac limits rather than facilitates oxygen transfer to the fetus-a review Placenta 24 suppl A 2003 S86-S93.
2. B Gellersen., K Reimann., A Samalecos., et al. Invasiveness of human endometrial stromal cells is promoted by decidualization and by trophoblast-derived signals Hum Reprod 25 2010 862-873.
3. E Jauniaux., J Johns., B Gulbis., et al. Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking Am J Obstet Gynecol 197 58 2007 e1-e6.
4. J Hustin., JP Schaaps Echographic and anatomic studies of the maternotrophoblastic border during the first trimester of pregnancy Am J Obstet Gynecol 157 1987 162-168.
5. GJ Burton., E Jauniaux., AL Watson Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd Collection revisited Am J Obstet Gynecol 181 1999 718-724.
6. JP Schaaps., J Hustin In vivo aspect of the maternal-trophoblastic border during the first trimester of gestation Trophoblast Res 3 1988 39-48.
7. E Jauniaux., AL Watson., J Hempstock., et al. Onset of maternal arterial bloodflow and placental oxidative stress: a possible factor in human early pregnancy failure Am J Pathol 157 2000 2111-2122.
8. R Pijnenborg., L Vercruysse., M Hanssens The uterine spiral arteries in human pregnancy: facts and controversies Placenta 27 2006 939-958.
9. LK Harris Review: Trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel Placenta 31 suppl 2010 S93-S98.
10. E Jauniaux., J Hempstock., N Greenwold., et al. Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies Am J Pathol 162 2003 115-125.
11. SE Hiby., R Apps., AM Sharkey., et al. Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2 J Clin Invest 120 2010 4102-4110.
12. GJ Burton., AW Woods., E Jauniaux., et al. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy Placenta 30 2009 473-482.
13. J Hustin., E Jauniaux., JP Schaaps Histological study of the materno-embryonic interface in spontaneous abortion Placenta 11 1990 477-486.
14. J Hempstock., E Jauniaux., N Greenwold., et al. The contribution of placental oxidative stress to early pregnancy failure Hum Pathol 34 2003 1265-1275.
15. IA Brosens The utero-placental vessels at term -the distribution and extent of physiological changes Trophoblast Res 3 1988 61-67.
16. CB Martin., HS McGaughey., IH Kaiser., et al. Intermittent functioning of the uteroplacental arteries Am J Obstet Gynecol 90 1964 819-823.
17. GJ Burton., HW Yung., T Cindrova-Davies., et al. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia Placenta 30 suppl A 2009 S43-S48.
18. JW Meekins., R Pijnenborg., M Hanssens., et al. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies Br J Obstet Gynaecol 101 1994 669-674.
19. GJ Burton., AL Watson., J Hempstock., et al. Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy J Clin Endocrinol Metab 87 2002 2954-2959.
20. CJ Jones., JD Aplin., GJ Burton First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium Placenta 31 2010 576-580.
21. J Hempstock., T Cindrova-Davies., E Jauniaux., et al. Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study Reprod Biol Endocrinol 2 2004 58.
22. J Arias-Stella The Arias-Stella reaction: facts and fancies four decades after Adv Anat Pathol 9 2002 12-23.
23. M Mikolajczyk., J Skrzypczak., K Szymanowski., et al. The assessment of LIF in uterine flushing -a possible new diagnostic tool in states of impaired infertility Reprod Biol 3 2003 259-270.
24. E Tuckerman., SM Laird., R Stewart., et al. Markers of endometrial function in women with unexplained recurrent pregnancy loss: a comparison between morphologically normal and retarded endometrium Hum Reprod 19 2004 196-205.
25. P Kaufmann., DK Sen., G Schweikhert Classification of human placental villi. 1. Histology Cell Tissue Res 200 1979 409-423.
26. EM Ramsey., MW Donner Placental Vasculature and Circulation. Anatomy, Physiology, Radiology, Clinical Aspects, Atlas and Textbook 1980 Georg Thieme Stuttgart 101.
27. TM Mayhew., C Ohadike., PN Baker., et al. Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction Placenta 24 2003 219-226.
28. CJ Jones., H Fox Ultrastructure of the normal human placenta Electron Microsc Rev 4 1991 129-178.
29. AM Carter Placental oxygen consumption. Part I: in vivo studies-a review Placenta 21 suppl A 2000 S31-S37.
30. M Hemberger., R Udayashankar., P Tesar., et al. ELF5-enforced transcriptonal networks define an epigentically regulated trophoblast stem cell compartment in the human placenta Hum Mol Genet 19 2010 2456-2467.
31. TM Mayhew., L Leach., R McGee., et al. Proliferation, differentiation and apoptosis in villous trophoblast at 13-41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes Placenta 20 1999 407-422.
32. JL Frendo., L Cronier., G Bertin., et al. Involvement of connexin 43 in human trophoblast cell fusion and differentiation J Cell Sci 116 2003 3413-3421.
33. M Mangeney., M Renard., G Schlecht-Louf., et al. Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins Proc Natl Acad Sci U S A 104 2007 20534-20539.
34. NM Fogarty., TM Mayhew., AC Ferguson-Smith., et al. A quantitative analysis of transcriptionally active syncytiotrophoblastic nuclei across human gestation J Anat 219 2011 601-610.
35. NM Fogarty., AC Ferguson-Smith., GJ Burton Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage Am J Pathol 183 2013 144-152.
36. P Brownbill., D Mahendran., D Owen., et al. Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytio-trophoblast Am J Physiol Regul Integr Comp Physiol 278 2000 R677-R683.
37. MS Longtine, Chen B., AO Odibo, Zhong Y., DM Nelson Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR Placenta 33 5 2012 352-359.
38. GJ Burton., DS Charnock-Jones., E Jauniaux Regulation of vascular growth and function in human placenta Reproduction 138 2009 895-902.
39. P Kaufmann., U Bruns., R Leiser., et al. The fetal vascularisation of term placental villi. II. Intermediate and terminal villi Anat Embryol (Berl) 173 1985 203-214.
40. TM Mayhew., DS Charnock Jones., P Kaufmann Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies Placenta 25 2004 127-139.
41. E Jauniaux., B Gulbis Fluid compartments of the embryonic environment Hum Reprod Update 6 2000 268-278.
42. E Jauniaux., B Gulbis., D Jurkovic., et al. Protein and steroid levels in embryonic cavities in early human pregnancy Hum Reprod 8 1993 782-787.
43. B Gulbis., E Jauniaux., F Cotton., et al. Protein and enzyme patterns in the fluid cavities of the first trimester gestational sac: relevance to the absorptive role of the secondary yolk sac Mol Hum Reprod 4 1998 857-862.
44. KA Burke., E Jauniaux., GJ Burton., et al. Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation Placenta 34 2013 1105-1109.
45. S Hauguel., JC Challier., L Cedard., et al. Metabolism of the human placenta perfused in vitro: glucose transfer and utilization, O2 consumption, lactate and ammonia production Pediatr Res 17 1983 729-732.
46. E Jauniaux., J Hempstock, Teng C., et al. Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy; maintenance of redox potential in a low oxygen environment J Clin Endocrinol Metab 90 2005 1171-1175.
47. AL Fowden., C Sibley., W Reik., et al. Imprinted genes, placental development and fetal growth Horm Res 65 suppl 3 2006 50-58.
48. HW Yung., S Calabrese., D Hynx., et al. Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction Am J Pathol 173 2008 451-462.
49. F Colleoni., N Padmanabhan., HW Yung., et al. Suppression of mitochondrial electron trnasport chain function in the hypoxic human placenta: a role for miR-210 and protein synthesis inhibition PLoS ONE 8 2013 e55194.
50. M Desforges., CP Sibley Placental nutrient supply and fetal growth Int J Dev Biol 54 2010 377-390.
51. MD Bain., DK Copas., A Taylor., et al. Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules J Physiol 431 1990 505-513.
52. P Brownbill., D Edwards., C Jones., et al. Mechanisms of alphafetoprotein transfer in the perfused human placental cotyledon from uncomplicated pregnancy J Clin Invest 96 1995 2220-2226.
53. J Stulc., J Svihovec., J Drabkova., et al. Electrical potential difference across the mid-term human placenta Acta Obstet Gynecol Scand 57 1978 125-126.
54. DJ Mellor., F Cockburn., MM Lees., et al. Distribution of ions and electrical potential differences between mother and fetus in the human at term J Obstet Gynaecol Br Commonw 76 1969 993-998.
55. S Ward., E Jauniaux., C Shannon., et al. Electrical potential difference between exocelomic fluid and maternal blood in early pregnancy Am J Physiol 274 1998 R1492-R1495.
56. DE Atkinson., RDH Boyd., CP Sibley Placental transfer JD Neill. Placental Transfer 2006 Elsevier Amsterdam 2787-2846.
57. PT Ayuk., D Theophanous., SW D’Souza., et al. L-arginine transport by the microvillous plasma membrane of the syncytiotrophoblast from human placenta in relation to nitric oxide production: effects of gestation, preeclampsia, and intrauterine growth restriction J Clin Endocrinol Metab 87 2002 747-751.
58. NP Illsley Glucose transporters in the human placenta Placenta 21 2000 14-22.
59. JL Hughes., IM Doughty., JD Glazier., et al. Activity and expression of the Na(+)/H(+) exchanger in the microvillous plasma membrane of the syncytiotrophoblast in relation to gestation and small for gestational age birth Pediatr Res 48 2000 652-659.
60. CP Sibley., RDH Boyd Mechanisms of transfer across the human placenta PA Polin., WW Fox. SH Abman Fetal and Neonatal Physiology 2004 Saunders Philadelphia 111-122.
61. RB Wilkening., G Meschia Fetal oxygen uptake, oxygenation, and acid-base balance as a function of uterine blood flow Am J Physiol 244 1983 H749-H755.
62. MU Baumann., S Deborde., NP Illsley Placental glucose transfer and fetal growth Endocrine 19 2002 13-22.
63. RM Lewis., S Brooks., IP Crocker., et al. Review: Modelling placental amino acid transfer-from transporters to placental function Placenta 34 suppl 2013 S46-S51.
64. RE Gimeno., DJ Hirsch., S Punreddy., et al. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality J Biol Chem 278 2003 49512-49516.
65. AK Duttaroy Transport of fatty acids across the human placenta: a review Prog Lipid Res 48 2009 52-61.
66. J Dancis., S Kammerman., V Jansen., et al. Transfer of urea, sodium, and chloride across the perfused human placenta Am J Obstet Gynecol 141 1981 677-681.
67. TJ Birdsey., RD Boyd., CP Sibley., et al. Microvillous membrane potential (Em) in villi from first trimester human placenta: comparison to Em at term Am J Physiol 273 1997 R1519-R1528.
68. G Riquelme Placental chloride channels: a review Placenta 30 2009 659-669.
69. L Belkacemi., I Bedard., L Simoneau., et al. Calcium channels, transporters and exchangers in placenta: a review Cell Calcium 37 2005 1-8.
70. CP Sibley., MA Turner., I Cetin., et al. Placental phenotypes of intrauterine growth Pediatr Res 58 2005 827-832.
71. CP Sibley Understanding placental nutrient transfer-why bother? New biomarkers of fetal growth J Physiol 587 2009 3431-3440.
72. KE Brett., ZM Ferraro., J Yockell-Lelievre., et al. Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta Int J Mol Sci 15 2014 16153-16185.
73. T Cindrova-Davies., EA Herrera, Niu Y., et al. Reduced cystathionine gamma-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator Am J Pathol 182 2013 1448-1458.
74. RC Tuckey Progesterone synthesis by the human placenta Placenta 26 2005 273-281.
75. RC Tuckey., Z Kostadinovic., KJ Cameron Cytochrome P-450scc activity and substrate supply in human placental trophoblasts Mol Cell Endocrinol 105 1994 103-109.
76. CR Mendelson, Jiang B., JM Shelton., et al. Transcriptional regulation of aromatase in placenta and ovary J Steroid Biochem Mol Biol 95 2005 25-33.
77. Bo M., I Boime Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo J Biol Chem 267 1992 3179-3184.
78. JL Jameson., AN Hollenberg Regulation of chorionic gonadotropin gene expression Endocr Rev 14 1993 203-221.
79. P Licht., A Losch., R Dittrich., et al. Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis Hum Reprod Update 4 1998 532-538.
80. S Banerjee., A Smallwood., AE Chambers., et al. A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down’s syndrome pregnancies Reprod Biol Endocrinol 3 2005 25.
81. LA Cole Hyperglycosylated hCG, a review Placenta 31 2010 653-664.
82. S Shenhav., O Gemer., E Sassoon., et al. Mid-trimester triple test levels in early and late onset severe pre-eclampsia Prenat Diagn 22 2002 579-582.
83. A Kharfi., Y Giguere., P De Grandpre., et al. Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies Clin Biochem 38 2005 717-721.
84. MC Lacroix., J Guibourdenche., JL Frendo., et al. Human placental growth hormone-a review Placenta 23 suppl A 2002 S87-S94.
85. DR Tessier., ZM Ferraro., A Gruslin Role of leptin in pregnancy: consequences of maternal obesity Placenta 34 2013 205-211.
86. M Kalousova., A Muravska., T Zima Pregnancy-associated plasma protein A (PAPP-A) and preeclampsia Adv Clin Chem 63 2014 169-209.
87. S Suri., S Muttukrishna., E Jauniaux 2D-Ultrasound and endocrinologic evaluation of placentation in early pregnancy and its relationship to fetal birthweight in normal pregnancies and pre-eclampsia Placenta 34 2013 745-750.
88. VL Clifton Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival Placenta 31 suppl 2010 S33-S39.
89. JG Eriksson., E Kajantie., C Osmond., et al. Boys live dangerously in the womb Am J Hum Biol 22 2010 330-335.
90. S Muralimanoharan., A Maloyan., L Myatt Evidence of sexual dimorphism in the placental function with severe preeclampsia Placenta 34 12 2013 1183-1189.
91. T Jansson., K Ylven., M Wennergren., et al. Glucose transport and system A activity in syncytiotrophoblast microvillous and basal plasma membranes in intrauterine growth restriction Placenta 23 2002 392-399.
92. T Jansson., V Scholtbach., TL Powell Placental transport of leucine and lysine is reduced in intrauterine growth restriction Pediatr Res 44 1998 532-537.
93. S Norberg., TL Powell., T Jansson Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters Pediatr Res 44 1998 233-238.
94. S Roos., TL Powell., T Jansson Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression and regulation Am J Physiol Regul Integr Comp Physiol 287 2004 R886-R893.
95. T Jansson., M Wennergren., NP Illsley Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation J Clin Endocrinol Metab 77 1993 1554-1562.
96. M Johansson., L Karlsson., M Wennergren., et al. Activity and protein expression of Na+/K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction J Clin Endocrinol Metab 88 2003 2831-2837.
97. H Strid., E Bucht., T Jansson., et al. ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes Placenta 24 2003 445-452.
98. M Johansson., JD Glazier., CP Sibley., et al. Activity and protein expression of the Na+/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies J Clin Endocrinol Metab 87 2002 5686-5694.
99. P Settle., K Mynett., P Speake., et al. Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta Placenta 25 2004 496-504.
100. CA Boyd., EK Lund L-proline transport by brush border membrane vesicles prepared from human placenta J Physiol 315 1981 9-19.
101. JA Whitsett., ET Wallick [3H]ouabain binding and Na+-K+-ATPase activity in human placenta Am J Physiol 238 1980 E38-E45.
102. D Lajeunesse., MG Brunette Sodium gradient-dependent phosphate transport in placental brush border membrane vesicles Placenta 9 1988 117-128.
103. DF Balkovetz., FH Leibach., VB Mahesh., et al. Na+-H+ exchanger of human placental brush-border membrane: identification and characterization Am J Physiol 251 1986 C852-C860.
104. M Bara., JC Challier., A Guiet-Bara Membrane potential and input resistance in syncytiotrophoblast of human term placenta in vitro Placenta 9 1988 139-146.