A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation

Journal of Anatomy

Volumn 219, Issue 5, 2011, Pages 601-610

  Fogarty, N M E ^a   Mayhew, T M ^b   Ferguson Smith, A C ^a   Burton, G J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Human placenta; Stereology; Syncytiotrophoblast; Transcription

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLINE; DNA DIRECTED RNA POLYMERASE; MESSENGER RNA; PROTEIN UPSTREAM BINDING FACTOR; RNA POLYMERASE II; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CYTOTROPHOBLAST; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PLACENTA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SYNCYTIOTROPHOBLAST; SYNCYTIUM; TROPHOBLAST;

BIOLOGICAL MARKERS; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GESTATIONAL AGE; HUMANS; IMMUNOHISTOCHEMISTRY; PLACENTA; POL1 TRANSCRIPTION INITIATION COMPLEX PROTEINS; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PREGNANCY TRIMESTER, THIRD; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA POLYMERASE II; TRANSCRIPTION, GENETIC; TROPHOBLASTS;

EID: 80053915312     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2011.01417.x     Document Type: Article

References (34)

1. Cantle SJ, Kaufmann P, Luckhardt M, et al. (1987) Interpretation of syncytial sprouts and bridges in the human placenta. Placenta 8, 221-234.
2. Cheng YH, Nicholson RC, King B, etal. (2000) Corticotropin-releasing hormone gene expression in primary placental cells is modulated by cyclic adenosine 3', 5'-monophosphate. J Clin Endocrinol Metab 85, 1239-1244.
3. Cole LA (2010) Hyperglycosylated hCG, a review. Placenta 31, 653-664.
4. De Cesare D, Fimia GM, Sassone-Corsi P (1999) Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci 24, 281-285.
5. Delidaki M, Gu M, Hein A, etal. (2011) Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line. Mol Cell Endocrinol 332, 213-220.
6. Depoix C, Tee MK, Taylor RN (2011) Molecular regulation of human placental growth factor (PlGF) gene expression in placental villi and trophoblast cells is mediated via the protein kinase A pathway. Reprod Sci 18, 219-228.
7. Ellery PM, Cindrova-Davies T, Jauniaux E, etal. (2009) Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta. Placenta 30, 329-334.
8. Fox H (1965) The significance of villous syncytial knots in the human placenta. J Obstet Gynaecol Br Common 72, 347-355.
9. Galton M (1962) DNA content of placental nuclei. J Cell Biol 13, 183-191.
10. Gaspard UJ, Hustin J, Reuter AM, etal. (1980) Immunofluorescent localization of placental lactogen, chorionic gonadotrophin and its alpha and beta subunits in organ cultures of human placenta. Placenta 1, 135-144.
11. Gaunt M, Ockleford CD (1986) Microinjection of human placenta. II: biological application. Placenta 7, 325-331.
12. Gauster M, Siwetz M, Orendi K, etal. (2010) Caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion. Cell Death Differ 17, 336-345.
13. Glibetic M, Taylor L, Larson D, etal. (1995) The RNA polymerase I transcription factor UBF is the product of a primary response gene. J Biol Chem 270, 4209-4212.
14. Huppertz B, Frank HG, Kaufmann P (1999a) The apoptosis cascade - morphological and immunohistochemical methods for its visualization. Anat Embryol (Berl) 200, 1-18.
15. Huppertz B, Frank HG, Reister F, etal. (1999b) Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro. Lab Invest 79, 1687-1702.
16. Huppertz B, Kadyrov M, Kingdom JC (2006) Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 195, 29-39.
17. Jauniaux E, Watson AL, Hempstock J, etal. (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol 157, 2111-2122.
18. Kar M, Ghosh D, Sengupta J (2007) Histochemical and morphological examination of proliferation and apoptosis in human first trimester villous trophoblast. Hum Reprod 22, 2814-2823.
19. Kim J, Lu J, Quinn PG (2000) Distinct cAMP response element-binding protein (CREB) domains stimulate different steps in a concerted mechanism of transcription activation. Proc Natl Acad Sci USA 97, 11292-11296.
20. Loukeris K, Sela R, Baergen RN (2010) Syncytial knots as a reflection of placental maturity: reference values for 20 to 40 weeks' gestational age. Pediatr Dev Pathol 13, 305-309.
21. Martin BJ, Spicer SS (1973) Ultrastructural features of cellular maturation and aging in human trophoblast. J Ultrastruct Res 43, 133-149.
22. Mayhew TM, Gundersen HJ (1996) 'If you assume, you can make an ass out of u and me': a decade of the disector for stereological counting of particles in 3D space. J Anat 188(Pt 1), 1-15.
23. Mayhew TM, Simpson RA (1994) Quantitative evidence for the spatial dispersal of trophoblast nuclei in human placental villi during gestation. Placenta 15, 837-844.
24. Mayhew TM, Leach L, McGee R, etal. (1999) Proliferation, differentiation and apoptosis in villous trophoblast at 13-41weeks of gestation (including observations on annulate lamellae and nuclear pore complexes). Placenta 20, 407-422.
25. Maymo JL, Perez Perez A, Duenas JL, etal. (2010) Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways. Endocrinology 151, 3738-3751.
26. Mayr BM, Canettieri G, Montminy MR (2001) Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. Proc Natl Acad Sci USA 98, 10936-10941.
27. Palancade B, Bensaude O (2003) Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation. Eur J Biochem 270, 3859-3870.
28. Rote NS, Wei BR, Xu C, et al. (2010) Caspase 8 and human villous cytotrophoblast differentiation. Placenta 31, 89-96.
29. Shaywitz AJ, Greenberg ME (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68, 821-861.
30. Simpson RA, Mayhew TM, Barnes PR (1992) From 13weeks to term, the trophoblast of human placenta grows by the continuous recruitment of new proliferative units: a study of nuclear number using the disector. Placenta 13, 501-512.
31. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134(Pt 2), 127-136.
32. Stewart CA, Dell'Orco RT (1992) Expression of proliferating cell nuclear antigen during the cell cycle of human diploid fibroblasts. In Vitro Cell Dev Biol 28A, 211-214.
33. Strauss JF, Barbieri RL (2009) Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, pp. 256. Philadelphia: Saunders Elsevier.
34. Voit R, Grummt I (2001) Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc Natl Acad Sci USA 98, 13631-13636.