The epidermal permeability barrier: From Saran® wrap to biosensor

Skin Barrier

Volumn , Issue , 2005, Pages 25-31

  Elias, Peter M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85129426294     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (29)

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2. Blank IH. Transport across the stratum corneum. Toxicol Appl Pharmacol 1969; 3(suppl):23-29.
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6. Odland G, Reed T. Epidermis. In: Zelickson A, ed. Ultrastructure of Normal and Abnormal Skin. Philadelphia: Lea & Febiger, 1967:54-75.
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11. Elias PM, Cullander C, Mauro T, Rassner U, Komuves L, Brown BE, Menon GK. The secretory granular cell: the outermost granular cell as a specialized secretory cell. J Invest Dermatol Symp Proc 1998; 3:87-100.
12. Elias PM, Menon GK. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 1991; 24:1-26.
13. Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol 2001; 117:44-51.
14. Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM. NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem 2002; 277:47399-47406.
15. Lundstrom A, Serre G, Haftek M, Egelrud T. Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation. Arch Dermatol Res 1994; 286:369-375.
16. Horikoshi T, Igarashi S, Uchiwa H, Brysk H, Brysk MM. Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desquamation. Br J Dermatol, 1999; 141:453-459.
17. Eckholm IE, Brattsand M, Egelrud T. Stratum corneum tyrptic enzyme in normal epidermis: a missing link in the desquamation process. J Invest Dermatol 2000; 114: 56-63.
18. Menon GK, Elias PM. Morphologic basis for a pore-pathway in mammalian stratum corneum. Skin Pharmacol 1997; 10:235-246.
19. Bernard D, Mehul B, Thomas-Collignon A, Simonetti L, Remy V, Bernard MA, Schmidt R. Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2. J Invest Dermatol 2003; 120:592-600.
20. Scott IR, Harding CR. Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 1986; 115:84-92.
21. Krien P, Kermici M. Evidence for the existence of a self-regulated enzymatic process within human stratum corneum-an unexpected role for urocanic acid. J Invest Dermatol 2000; 115:414-420.
22. Fluhr JW, Mao-Qiang M, Brown BE, Wertz PW, Crumrine D, Sundberg JP, Feingold KR, Elias PM. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol 2003; 120:728-737.
23. Elias PM, Wood LC, Feingold KR. Epidermal pathogenesis of inflammatory dermatoses. Am J Contact Dermatol 1999; 10:119-126.
24. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 1995; 95:2281-2290.
25. Mao-Qiang M, Brown BE, Wu-Pong S, Feingold KR, Elias PM. Exogenous nonphysiologic vs. physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction. Arch Dermatol, 1995; 131:809-816.
26. Elias PM, Tsai J, Menon GK, Holleran WM, Feingold KR. The potential of metabolic interventions to enhance transdermal drug delivery. J Investig Dermatol Symp Proc 2002; 7:79-85.
27. Wood LC, Elias PM, Calhoun C, Tsai JC, Grunfeld C, Feingold KR. Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis. J Invest Dermatol 1996; 106:397-403.
28. Menon GK, Price LF, Bommannan B, Elias PM, Feingold KR. Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J Invest Dermatol 1994; 102:789-795.
29. Elias PM, Ahn SK, Denda M, Brown BE, Crumrine D, Kimutai LK, Komuves L, Lee SH, Feingold KR. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 2002; 119:1128-1136.