Transgenic plants for the production of polyhydroxyalkanoates, a family of biodegradable thermoplastics and elastomers

Transgenic Plant Research

Volumn , Issue , 2022, Pages 201-218

  Poirier, Yves ^a   Nawrath, Christiane ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Arabidopsis; PHA; Plant; Plastic; Polyhydroxyalkanoate; Polyhydroxybutyrate

Indexed keywords

EID: 85127633433     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (82)

1. Anderson, A.J. and Dawes, E.A. (1990). Occurence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiological Reviews, 54, 450-472.
2. Anonymous (1994a). Feed situation and outlook report. May, U.S. Department of Agriculture.
3. Anonymous (1994b). The CRB commodity yearbook. New York: John Wiley & Sons Inc.
4. Anonymous (1994c). Oil crops: situation and outlook. July, U.S. Department of Agriculture.
5. Barnard, G.N. and Sanders, J.K.M. (1989). The poly-β-hydroxybutyrate granule in vivo. Journal of Biological Chemistry, 264, 3286-3291.
6. Brandl, H., Bachofen, R., Mayer, J. and Wintermantel, E. (1995). Degradation and applications of polyhydroxyalkanoates. Canadian Journal of Microbiology, 41, 143-153.
7. Byrom, D. (1987). Polymer synthesis by microorganisms: technology and economics. Trends in Biotechnology, 5, 246-250.
8. Byrom, D. (1990). Industrial production of copolymer from Alcaligenes eutrophus. In Novel biodegradable microbial polymers, edited by E.A. Dawes, pp. 13-117. Dordrecht: Kluwer.
9. De Koning, G.J.M., Van Bilesen, H.M.M., Lemstra, P.J., Hazenberg, W., Withold, B., Preusting, H., Van der Galiën, J.G., Schirmer, A. and Jendrossek, D. (1994). A biodegradable rubber by crosslinking poly(hy-droxyalkanoate) from Pseudomonas oleovorans. Polymer, 35, 2090-2097.
10. Doi, Y., Kitamura, S. and Abe, H. (1995). Microbial synthesis and characterization of poly(3-hydroxy-butyrate-co-3-hydroxyhexanoate). Macromolecules, 28, 4822-4828.
11. Eschenlauer, A.C. Stoup, S.K., Srienc, F. and Somers, D.A. (1996). Production of heteropolymeric polyhyd-roxyalkanoate in Escherichia coli from a single carbon source. International Journal of Biological Macro-molecules, 19, 121-130.
12. Fritzsche, K., Lenz, R. and Fuller, R.C. (1990a). Production of unsaturated polyesters by Pseudomonas oleovorans. International Journal of Biological Macromolecules, 12, 85-91.
13. Fritzsche, K., Lenz, R. and Fuller, R.C. (1990b). Bacterial polyesters containing branched poly(/?-hydroxyal-kanoate) units. International Journal of Biological Macro-molecules, 12, 92-101
14. Gagnon, K.D., Lenz, R.W., Farris, RJ. and Fuller, R.C. (1992). Crystallization behaviour and its influence on the mechanical properties of a thermoplastic elastomer produced by Pseudomonas oleovorans. Macro-molecules, 25, 3723-3728.
15. Gerngross, T.U. and Martin, D.P. (1995). Enzyme-catalyzed synthesis of poly[(R)-(-)-3-hydroxybutyrate]: formation of macroscopic granules in vitro. Proceedings of the National Academy of Sciences USA, 92, 6279-6283.
16. Gerngross, T.U., Snell, K.D., Peoples, O.P., Sinskey, A.J., Csuhai, E., Masamune, S. and Stubbe, J. (1994). Over-expression and purification of the soluble polyhy-droxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity. Biochemistry, 33, 9311-9320.
17. Goddijn, O.J.M. and Pen, J. (1995). Plants as bioreactors. Trends in Biotechnology, 13, 379-387.
18. Hänggi, U.J. (1990). Pilot scale production of PHB with Alcaligenes latus. In Novel Biodegradable Microbial Polymers, edited by E.A. Dawes, pp. 65-70. Dordrecht: Kluwer.
19. Haywood, G.W., Anderson, A.J. and Dawes, E.A. (1989). The importance of PHB-synthase substrate specificity in polyhydroxyalkanoate synthesis by Alcaligenes eutrophus. FEMS Microbiology Letters, 57, 1-6.
20. Haywood, G.W., Anderson, A.J., Ewing, D.F. and Dawes, E.A. (1990). Accumulation of a polyhydroxyalkanoate containing primarily 3-hydroxydecanoate from simple carbohydrate substrates by Pseudomonas sp. strain NOME 40135. Applied and Environmental Microbiology, 56, 3354-3359.
21. Haywood, G.W., Anderson, A.J., Wilhams, D.R., Dawes, E.A. and Ewing, D.F. (1991). Accumulation of a poly-(hydroxyalkanoate) copolymer containing primarily 3-hydroxyvalerate from simple carbohydrate substrates by Rhodococcus sp. NCEMB 40126. International Journal of Biological Macromolecules, 13, 83-88.
22. Hodgson, J. (1992). Whole animals for wholesale protein production. Biotechnology, 10, 863-866.
23. Holland, S.J., Jolly, A.M., Yasin, M. and Tighe, B.J. (1987). Polymers for biodegradable medical devices II. Hydroxybutyrate-hydroxyvalerate copolymers: hy-drolytic degradation studies. Biomaterials, 8, 289-295.
24. Holmes, P.A. (1988). Biologically produced (R)-3-hydroxy-alkanoate polymers and copolymers. In Development in crystalline polymers-2. edited by D.C. Basset, pp. 1-65. London: Elsevier.
25. Huang, R. and Reusch, R.N. (1995). Genetic competence in Escherichia coli requires poly-β Mvydroxybutyrate/calcium polyphosphate membrane complexes and certain divalent cations. Journal of Bacteriology, 177, 486-490.
26. 13C nuclear magnetic resonance studies of Pseudomonas putida fatty acid metabolic routes involved in poly(3-hydroxyalkanoate) synthesis. Journal of Bacteriology, 176, 1661-1666.
27. Huijberts, G.N.M., Eggink, G, de Waard, P., Huisman, G.W. and Witholt, B. (1992). Pseudomonas putida KT2442 cultivated on glucose accumulates poly (3-hydroxyalkanoates) consisting of saturated and unsaturated monomers. Applied and Environmental Microbiology, 58, 536-544.
28. Jendrossek, D., Schirmer, A. and Schlegel, H.G (1996). Biodegredation of polyhydroxyalkanoic acids. Applied Microbiology and Biotechnology, 46, 451-463.
29. John, M.E. and Keller, G. (1996). Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxy-butyrate in fiber cells. Proceedings of the National Academy of Sciences USA, 93, 12768-12773.
30. Jorgensen, R. (1990). Altered gene expression in plants due to trans interactions between homologous genes. Trends in Biotechnology, 8, 340-344.
31. Kato, M., Bao, HJ., Kang, C.K., Fukui, T. and Doi, Y. (1996). Production of a novel copolyester of 3-hydroxy-butyric acid and medium-chain-length 3-hydroxy-alkanoic acids by Pseudomonas SP61-3 from sugars. Applied Microbiology and Biotechnology, 45, 363-370.
32. Kishore, G.M. and Somerville, C.R. (1993). Genetic engineering of commercially useful biosynthetic pathways in transgenic plants. Current Opinions in Biotechnology, 4, 152-158.
33. Kraak, M.N., Kessler, B. and Witholt, B. (1997). In vitro activities of granule-bound poly[(R)-3-hydroxy-alkanoate] polymerase CI of Pseudomonas oleovorans: development of an activity test for medium-chain-length-poly(3-hydroxyalkanoate) polymerase. European Journal of Biochemistry, 250, 432-439.
34. Kreuz, K. and Kleinig, H. (1984). Synthesis of prenyl lipids in cells of spinach leafs. European Journal of Biochemistry, 141, 531-535.
35. Lageveen, R.G., Huisman, G.W., Preusting, H., Ketelaar, P., Eggink, G. and Witholt, B. (1988). Formation of polyesters by Pseudomonas oleovorans: effect of substrates on formation and composition of poly-(R)-3-hydroxyalkanoates and poly-(R)-3-hydroxyal-kenoates. Applied and Environmental Microbiology, 54, 2924-2932.
36. Langenbach, S., Rehm, B.H. and Steinbüchel, A. (1997). Functional expression of the PHA synthase gene phaCl from Pseudomonas aeruginosa in Escherichia coli results in poly(3-hydroxyalkanoate) synthesis. FEMS Microbiology Letters, 150, 303-309.
37. Leaf, T.A., Peterson, M.S., Stoup, S.K., Somers, D. and Srienc, F. (1996). Sacchoromyces cerevisiae expressing bacterial PHB synthase produces poly-3-hydroxy-butyrate. Microbiology, 142, 1169-1180.
38. Lenz, R.W., Kim, Y.B. and Fuller, R.C. (1992). Production of unusual bacterial polyesters by Pseudomonas oleovorans through cometabolism. FEMS Microbiology Reviews, 103, 207-214.
39. Lindsay, K.F. (1992). 'Truly degradable' resins are now truly commercial. Modern plastics, 2, 62-64.
40. Lundgren, D.G., Pfister, R.M. and Merrick, J.M. (1964). Structure of poly-^hydroxybutyric acid granules. Journal of General Microbiology, 34, 441-446.
41. Luzier, W.D. (1992). Material derived from biomass/bio-degradable materials. Proceedings of the National Academy of Sciences USA, 89, 839-842.
42. Marchessault, R.H., Monasterios, C.J. and Lepoutre, P. (1990). Properties of poly-/?-hydroxyalkanoate latex: nascent morphology, film formation and surface chemistry. In Novel biodegradable microbial polymers, edited by E.A. Dawes, pp. 97-112. Dordrecht: Kluwer.
43. Matavulj, M. and Molitoris, H.P. (1992). Fungal degradation of polyhydroxyalkanoates and a semiquantitative assay for screening their degradation by terrestrial fungi. FEMS Microbiology Reviews, 103, 323-332.
44. Meyerowitz, E.M. (1987). Arabidopsis thaliana. Annual Review of Genetics, 21, 93-111.
45. Murphy, D.J. (1993). Structure, function and biogenesis of storage lipid bodies and oleosins in plants. Progress in Lipids Research, 32, 247-280.
46. Nawrath, C, Poirier, Y. and Somerville, C.R. (1994a). Plastid targeting of the enzymes required for the production of polyhydroxybutyrate in higher plants. In Biodegradable plastics and polymers, edited by Y. Doi and K. Fukuda pp. 136-149. Amsterdam: Elsevier.
47. Nawrath, C, Poirier, Y. and Somerville, C.R. (1994b). Targeting of the polyhydroxybutyrate biosynthetic pathway to the plastids of Arabidopsis thaliana results in high-levels of polymer accumulation. Proceedings of the National Academy of Sciences USA, 91, 12760-12764.
48. Nawrath, C, Poirier, Y. and Somerville, C.R. (1995). Plant polymers for biodegradable plastics: cellulose, starch and polyhydroxyalkanoates. Molecular Breeding, 1, 105-122.
49. Pen, J., Molendyk, L., Quax, W.J., Symons, P.C., Van Ooijen, A.J.J., Van den Elzen, P.J.M., Rietveld, K. and Hoekema, A. (1992). Production of active Bacillus licheniformis alpha-amylase in tobacco and its application in starch liquefaction. Biotechnology, 10, 292-296.
50. Peoples, O.P. and Sinskey, A.J. (1989). Poly-jft-hydroxybuty-rate (PHB) biosynthesis in Alcaligenes eutrophus H16: identification and characterization of the PHB polymerase gene (phbC). Journal of Biological Chemistry, 264, 15298-15303.
51. Pieper-Fürst, U., Hussein Madkour, H., Mayer, F. and Steinbüchel, A. (1995). Identification of the region of a 14-kilodalton protein of Rhodoccocus ruber that is responsible for the binding of this phasin to polyhy-droxyalkanoic acid granules. Journal of Bacteriology, 177, 2513-2523.
52. Poirier, Y., Dennis, D.E., Klomparens, K. and Somerville, C. (1992a). Polyhydroxybutyrate, a biodegradable thermoplastic, produced in transgenic plants. Science, 256, 520-523.
53. Poirier, Y., Dennis. D., Klomparens, K., Nawrath, C. and Somerville, C. (1992b). Perspectives on the production of polyhydroxyalkanoates in plants. FEMS Microbiology Reviews, 103, 237-246.
54. Poirier, Y., Dennis, D.E., Nawrath, C, and Somerville, C. (1993). Progress toward biologically produced biodegradable thermoplastics. Advanced Materials, 5, 30-37.
55. Poirier, Y., Nawrath, C. and Somerville, C. (1995). Production of polyhydroxyalkanoates, a family of biodegradable plastics and elastomers, in bacteria and plants. Biotechnology, 13, 142-150.
56. Poirier, Y., Schechtman, L.A., Satkowski, M.M., Nöda, I. and Somerville, C. (1995). Synthesis of high molecular weight poly([R]-(-)-3-hydroxybutyrate) in transgenic Arabidopsis thaliana plant cells. International Journal of Biological Macromolecules, 17, 7-12.
57. Pryde, E.H. and Rothfus, J.A. (1989). Industrial and nonfood uses of vegetable oils. In Oil crops of the world, edited by G. Röbbelen, R.K. Downey and A. Ashri pp. 87-117. New York: McGraw-Hill.
58. Reusch, R.N. (1995). Low molecular weight complexed poly(3-hydroxybutyrate): a dynamic and versatile molecule in vivo. Canadian Journal of Microbiology, 41, 50-54.
59. Reusch, R.N., Hiske, T.W. and Sadoff, H.L. (1986). D-(-)-Poly-β-Mvydroxybutyrate membrane structure and its relationship to genetic transformability in Escherichia coli. Journal of Bacteriology, 168, 553-562.
60. Reusch, R.N. and Sadoff, H.L. (1988). Putative structure and function of a poly-^-hydroxybutyrate/calcium polyphosphate channel in bacterial plasma membranes. Proceedings of the National Academy of Sciences USA, 85, 4176-4180.
61. Reusch, R.N. and Sadoff, H.L. (1983). D-(-)-Poly-0-hydroxybutyrate in membranes of genetically competent bacteria. Journal of Bacteriology, 156, 778-788.
62. Rutenberg, M.W. and Solarek, D. (1984). Starch derivatives: production and uses. In Starch: chemistry and technology, edited by R.L. Whistler, J.N. BeMiller and E.F. Paschall pp. 311-388. Orlando: Academic Press.
63. 13C-labeled acetate and propionate. International Journal of Biological Macromolecules, 15, 287-292.
64. Schubert, P., Steinbüchel, A. and Schlegel, H.G. (1988). Cloning of the Alcaligenes eutrophus genes for synthesis of poly-β-hydroxybutyric acid (PHB) and synthesis of PHB in Escherichia coli. Journal of Bacteriology, 170, 5837-5847.
65. Seebach, D., Roggo, S. and Zimmermann, J. (1987). Biological-chemical preparation of 3-hydroxycarboxylic acids and their use in EPC-synthesis. In Stereochemistry of organic and bioorganic transformations, edited by W. Bartmann and K.B. Sharpless pp. 85-126. Weinheim: VCH Verlagsgesellschaft.
66. Sijmons, P.C., Dekker, B.M.M., Schrammeijer, B., Verwoerd, T.C, Van den Elzen, P.J.M. and Hoekema, A. (1990). Production of correctly processed human serum albumin in transgenic plants. Biotechnology, 8, 217-221.
67. Slater, S., Gallaher, T. and Dennis, D. (1992). Production of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) in a recombinant Escherichia coli strain. Applied and Environmental Microbiology, 58, 1089-1094.
68. Slater, S.C, Voige, W.H. and Dennis, D.E. (1988). Cloning and expression in Escherichia coli of the Alcaligenes eutrophus HI6 poly-β-hydroxybutyrate biosynthetic pathway. Journal of Bacteriology, 170, 4431-4436.
69. Stark, D.M., Timmermann, K.P., Barry, G.F., Preiss, J. and Kishore, G.M. (1992). Regulation of the amount of starch in plant tissues by ADP glucose Phosphorylase. Science, 258, 287-292.
70. Steinbüchel, A. (1991). Polyhydroxyalkanoic acids. In Novel biomaterials from biological sources, edited by D. Byrom. New York: MacMillan.
71. Steinbüchel, A., Aerts, K., Babel, W., Föllner, C, Liebergesell, M., Hussein Madkour, M. et al. (1995). Considerations on the structure and biochemistry of bacterial polyhydroxyalkanoic acid inclusions. Canadian Journal of Microbiology, 41, 94-105.
72. Steinbüchel, A., Hustede, E., Liebergesell, M., Pieper, U., Timm, A. and Valentin, H. (1992). Molecular basis for biosynthesis and accumulation of polyhydroxyalkanoic acid in bacteria. FEMS Microbiology Reviews, 103, 217-230.
73. Steinbüchel, A. and Schlegel, H.G. (1991). Physiology and molecular genetics of poly(j5-hydroxy-alkanoic acid) synthesis in Alcaligenes eutrophus. Molecular Microbiology, 5, 535-542.
74. Steinbüchel, A. and Valentin, H.E. (1995). Diversity of bacterial polyhydroxyalkanoic acids. FEMS Microbiology Letters, 128, 219-228.
75. Timm, A. and Steinbüchel, A. (1990). Formation of polyesters consisting of medium-chain-length 3-hydroxyal-kanoic acids from gluconate by Pseudomonas aeruginosa and other fluorescent pseudomonads. Applied and Environmental Microbiology, 56, 3360-3367.
76. Valentin, H.E. and Dennis, D. (1997). Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in recombinant Escherichia coli grown on glucose. Journal of Biotechnology, 58, 33-38.
77. van der Leij, F.R. and Witholt, B. (1995). Strategies for the sustainable production of new biodegradable polyesters in plants: a review. Canadian Journal of Microbiology, 41, 222-238.
78. Voelker, T.A., Worrell, A.C., Anderson, L., Bleibaum, J., Fan, C, Hawkins, D.J., Adke, S.E. and Davies, H.M. (1992). Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants. Science, 257, 72-74.
79. Wieczorek, R., Pries, A., Steinbüchel, A. and Mayer, F. (1995). Analysis of a 24-kilodalton protein associated with the polyhydroxyalkanoic acid granules in Alcaligenes eutrophus. Journal of Bacteriology, 177, 2425-2435.
80. Williams, D.R., Anderson, A.J., Dawes, E.A. and Ewing, D.F. (1994). Production of a co-polyester of 3-hydroxybutyric acid and 3-hydroxyvaleric acid from succinic acid by Rhodococcus ruber: biosynthetic considerations. Applied Microbiology and Biotechnology, 40, 717-723.
81. Williams, S., Friedrich, L., Dincher, S., Carozzi, N., Kessmann, H., Ward, E. and Ryals, J. (1992). Chemical regulation of Bacillus thuringiensis ∂-endotoxin expression in transgenic plants. Biotechnology, 10, 540-543.
82. Williams, M.D. and Sherman, D.H. (1996). Production of a polyhydroxyalkanoate biopolymer using a modified fatty acid synthase. Applied and Environmental Microbiology, 62, 2540-2546.