What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 29, Issue 1, 2016, Pages 57-75

  Greenblatt, Elliot Eliyahu ^a,b   Winkler, Tilo ^b   Harris, Robert Scott ^b   Kelly, Vanessa Jane ^b   Kone, Mamary ^b   Katz, Ira ^c,d   Martin, Andrew R ^e   Caillibotte, George ^c   Venegas, Jose ^b  

^a Massachusetts Institute of Technology   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c AIR LIQUIDE   (France)

^d LAFAYETTE COLLEGE   (United States)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

aerosol deposition; asthma; bronchoconstriction; escape fractions; sedimentation; ventilation

Indexed keywords

ADULT; AEROSOL; AEROSOL DEPOSITION; AIRWAY; ARTICLE; ASTHMA; BREATHING RATE; BRONCHOCONSTRICTION; CLINICAL ARTICLE; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG LOBE; LUNG VENTILATION; MALE; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; QUANTITATIVE STUDY; SEDIMENTATION;

EID: 85126486684     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2014.1197     Document Type: Article

References (25)

1. Darquenne C: Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 2012;25:140-147.
2. Usmani OS, Biddiscombe MF, and Barnes PJ: Regional lung deposition and bronchodilator response as a function of b2-agonist particle size. Am J Respir Crit Care Med. 2005;172:1497-1504.
3. Greenblatt EE, Winkler T, Harris RS, Kelly VJ, Kone M, and Venegas J: Analysis of three-dimensional aerosol deposition in pharmacologically relevant terms: Beyond black or white ROIs. J Aerosol Med Pulm Drug Deliv. 2015; 28:116-129.
4. Robertson HT, Glenny RW, Stanford D, McInnes LM, Luchtel DL, and Covert D: High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres. J Appl Physiol. 1997;82:943-953.
5. Miyawaki S, Tawhai MH, Hoffman EA, and Lin CL: Effect of carrier gas properties on aerosol distribution in a CTbased human airway numerical model. Ann Biomed Eng. 2012;40:1495-1507.
6. de Vasconcelos TF, Sapoval B, Andrade JS, Grotberg JB, Hu Y, and Filoche M: Particle capture into the lung made simple? J Appl Physiol. 2011;110:1664-1673.
7. Chan TL, and Lippmann M: Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans. Am Indust Hygiene Assoc J. 1980;41:399-409.
8. Kim CS, Hu S, DeWitt P, and Gerrity T: Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. J Appl Physiol. 1996;81: 2203-2213.
9. Darquenne C, van Ertbruggen C, and Prisk GK: Convective flow dominates aerosol delivery to the lung segments. J Appl Physiol. 2011;111:48-54.
10. Katz I, Majoral C, Montesantos S, Dubau C, Texereau J, Caillibotte G, and Pichelin M: Modeling the influence of the gas mixture on ventilation and aerosol deposition within pathological human lungs: Helium-oxygen vs. air. Am J Respir Crit Care Med. 2014;189:A6276.
11. Darquenne C, and Prisk GK: Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med. 2004;17:278-285.
12. Asthma GIf: Global Strategy for Asthma Management and Prevention. NIH Publication. 2002.
13. Finlay P, Martin A, Katz I, Vecellio L, Caillibotte G, and Venegas J: Aerosol delivery from a vibrating mesh nebulizer with holding chamber in helium/oxygen versus air. J Aerosol Med Pulm Drug Deliv. 2013;26:A20.
14. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, and Melo MFV: Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol. 2012;113:947-957.
15. Wongviriyawong C, Harris RS, Greenblatt E, Winkler T, and Venegas JG: Peripheral resistance: A link between global airflow obstruction and regional ventilation distribution. J Appl Physiol. 2013;114:504-514.
16. De Backer JW, Vos WG, Vinchurkar SC, Claes R, Drollmann A, Wulfrank D, Parizel PM, Germonpré P, and De Backer W: Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology. 2010;257:854-862.
17. G C. Anovarep: Compute the Anova for repeated measures and Holm-Sidak test for multiple comparisons if Anova is positive. 2008
18. Brown JS, Zeman KL, and Bennett WD: Regional deposition of coarse particles and ventilation distribution in healthy subjects and patients with cystic fibrosis. J Aerosol Med. 2001;14:443-454.
19. O'Riordan TG, and Smaldone GC: Regional deposition and regional ventilation during inhalation of pentamidine. CHEST J. 1994;105:396-401.
20. Trajan M, Logus J, Enns E, and Man S: Relationship between regional ventilation and aerosol deposition in tidal breathing. Am Rev Respir Dis. 1984;130:64-70.
21. Smaldone GC: Physiological and pathological considerations for aerosol deposition: Expiration and models of deposition. J Aerosol Med. 2000;13:387-391.
22. Sagalla RB, and Smaldone GC: Capturing the efficiency of vibrating mesh nebulizers: Minimizing upper airway deposition. J Aerosol Med Pulm Drug Deliv. 2014;27:341-348.
23. Cartier A, Malo J, Begin P, Sestier M, and Martin R: Time course of the bronchoconstriction induced by inhaled histamine and methacholine. J Appl Physiol. 1983;54:821-826.
24. Mannino F, Sposato B, Ricci A, Grasso D, De Clementi F, and Mariotta S: Induction and recovery phases of methacholine-induced bronchoconstriction using FEV1 according to the degree of bronchial hyperresponsiveness. Lung. 2001;179:137-145.
25. Venegas J, Winkler T, and Harris RS: Lung physiology and aerosol deposition imaged with positron emission tomography. J Aerosol Med Pulm Drug Deliv. 2013;26:1-8.