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Volumn 111, Issue 1, 2011, Pages 48-54

Convective flow dominates aerosol delivery to the lung segments

Author keywords

Aerosol transport; Computational fluid dynamics; Gravity; Inertia

Indexed keywords

DRUG;

EID: 79960249662     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00796.2010     Document Type: Article
Times cited : (32)

References (42)
  • 2
    • 0022539757 scopus 로고
    • Prediction of drug residence times in regions of the human respiratory tract following aerosol inhalation
    • Byron PR. Prediction of drug residence times in regions of the human respiratory tract following aerosol inhalation. J Pharm Sci 75:433-438, 1986. (Pubitemid 16083635)
    • (1986) Journal of Pharmaceutical Sciences , vol.75 , Issue.5 , pp. 433-438
    • Byron, P.R.1
  • 4
    • 71049138508 scopus 로고    scopus 로고
    • On intra-and intersubject variabilities of airflow in the human lungs
    • Choi J, Tawhai MH, Hoffman EA, Lin CL. On intra-and intersubject variabilities of airflow in the human lungs. Phys Fluids 21:101901, 2009.
    • (2009) Phys Fluids , vol.21 , pp. 101901
    • Choi, J.1    Tawhai, M.H.2    Hoffman, E.A.3    Lin, C.L.4
  • 5
    • 0036960222 scopus 로고    scopus 로고
    • Inertial deposition effects: A study of aerosol mechanics in the trachea using laser doppler velocimetry and fluorescent dye
    • DOI 10.1115/1.1516572
    • Corcoran TE, Chigier N. Inertial deposition effects: a study of aerosol mechanics in the trachea using laser Doppler velocimetry and fluorescent dye. J Biomech Eng 124:629-637, 2002. (Pubitemid 36123996)
    • (2002) Journal of Biomechanical Engineering , vol.124 , Issue.6 , pp. 629-637
    • Corcoran, T.E.1    Chigier, N.2
  • 6
    • 0031468326 scopus 로고    scopus 로고
    • Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm- diameter aerosol in the human lung
    • Darquenne C, Paiva M, West JB, Prisk GK. Effect of microgravity and hypergravity on deposition of 0.5-to 3-μm-diameter aerosol in the human lung. J Appl Physiol 83:2029-2036, 1997. (Pubitemid 28006505)
    • (1997) Journal of Applied Physiology , vol.83 , Issue.6 , pp. 2029-2036
    • Darquenne, C.1    Paiva, M.2    West, J.B.3    Prisk, G.K.4
  • 7
    • 45849110654 scopus 로고    scopus 로고
    • Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity
    • Darquenne C, Prisk GK. Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity. Eur J Appl Physiol 103:687-695, 2008.
    • (2008) Eur J Appl Physiol , vol.103 , pp. 687-695
    • Darquenne, C.1    Prisk, G.K.2
  • 8
    • 0031714079 scopus 로고    scopus 로고
    • Deposition and dispersion of 1-μm aerosol boluses in the human lung: Effect of micro- and hypergravity
    • Darquenne C, West JB, Prisk GK. Deposition and dispersion of 1-μm aerosol boluses in the human lung: effect of micro-and hypergravity. J Appl Physiol 85:1252-1259, 1998. (Pubitemid 28465049)
    • (1998) Journal of Applied Physiology , vol.85 , Issue.4 , pp. 1252-1259
    • Darquenne, C.1    West, J.B.2    Prisk, G.K.3
  • 9
    • 0032907942 scopus 로고    scopus 로고
    • Dispersion of 0.5- to 2-μm aerosol in μG and hypergravity as a probe of convective inhomogeneity in the lung
    • Darquenne C, West JB, Prisk GK. Dispersion of 0.5-to 2-μm aerosol in micro-and hypergravity as a probe of convective inhomogeneity in the human lung. J Appl Physiol 86:1402-1409, 1999. (Pubitemid 29172178)
    • (1999) Journal of Applied Physiology , vol.86 , Issue.4 , pp. 1402-1409
    • Darquenne, C.1    West, J.B.2    Prisk, G.K.3
  • 11
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • DOI 10.1016/j.jaerosci.2004.03.003, PII S0021850204000473
    • Grgic B, Finlay WH, Burnell P K P, Heenan AF. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J Aerosol Sci 35:1025-1040, 2004. (Pubitemid 38993745)
    • (2004) Journal of Aerosol Science , vol.35 , Issue.8 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3    Heenan, A.F.4
  • 12
    • 0022889862 scopus 로고
    • Deposition of particles in the human respiratory tract in the size range 0.0005-15 μm
    • DOI 10.1016/0021-8502(86)90035-2
    • Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W. Deposition of particles in the human respiratory tract in the size range 0.0005-15 μm. J Aerosol Sci 17:811-825, 1986. (Pubitemid 17492310)
    • (1986) Journal of Aerosol Science , vol.17 , Issue.5 , pp. 811-825
    • Heyder, J.1    Gebhart, J.2    Rudolf, G.3    Schiller, C.F.4    Stahlhofen, W.5
  • 14
    • 34249053835 scopus 로고    scopus 로고
    • Fluid flow and particle deposition analysis in a realistic extrathoracic airway model using unstructured grids
    • DOI 10.1016/j.jaerosci.2007.03.003, PII S0021850207000432
    • Jayaraju S, Brouns M, Verbanck S, Lacor C. Fluid flow and particle deposition analysis in a realistic extrathoracic airway model using unstructured grids. J Aerosol Sci 38:494-508, 2007. (Pubitemid 46795493)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.5 , pp. 494-508
    • Jayaraju, S.T.1    Brouns, M.2    Verbanck, S.3    Lacor, C.4
  • 15
    • 0033080637 scopus 로고    scopus 로고
    • A numerical study of particle motion within the human larynx and trachea
    • DOI 10.1016/S0021-8502(98)00043-3, PII S0021850298000433
    • Katz IM, Davis BM, Martonen TB. A numerical study of particle motion within the human larynx and trachea. J Aerosol Sci 30:173-183, 1999. (Pubitemid 28491123)
    • (1999) Journal of Aerosol Science , vol.30 , Issue.2 , pp. 173-183
    • Katz, I.M.1    Davis, B.M.2    Martonen, T.B.3
  • 16
    • 0031238741 scopus 로고    scopus 로고
    • Three-dimensional computational study of inspiratory aerosol flow through the larynx: The effect of glottal aperture modulation
    • DOI 10.1016/S0021-8502(96)00494-6, PII S0021850296004946
    • Katz IM, Martonen TB, Flaa W. Three-dimensional computational study of inspiratory aerosol flow through the larynx: the effect of glottal aperture modulation. J Aerosol Sci 28:1073-1083, 1997. (Pubitemid 27312065)
    • (1997) Journal of Aerosol Science , vol.28 , Issue.6 , pp. 1073-1083
    • Katz, I.M.1    Martonen, T.B.2    Flaa, W.3
  • 17
    • 0037323228 scopus 로고    scopus 로고
    • Laminar-to-turbulent fluid-particle flows in a human airway model
    • DOI 10.1016/S0301-9322(02)00131-3, PII S0301932202001313
    • Kleinstreuer C, Zhang Z. Laminar-to-turbulent fluid-particle flows in a human airway model. Int J Multiphase Flow 29:271-289, 2003. (Pubitemid 36230269)
    • (2003) International Journal of Multiphase Flow , vol.29 , Issue.2 , pp. 271-289
    • Kleinstreuer, C.1    Zhang, Z.2
  • 18
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • DOI 10.1046/j.1365-2125.2003.01892.x
    • Labiris NR, Dolovich MB. Pulmonary drug delivery. I. Physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56:588-599, 2003. (Pubitemid 37491710)
    • (2003) British Journal of Clinical Pharmacology , vol.56 , Issue.6 , pp. 588-599
    • Labiris, N.R.1    Dolovich, M.B.2
  • 19
    • 78249266316 scopus 로고    scopus 로고
    • Regional deposition of particles in an imaged-based airway model: Largeeddy simulation and left-right lung ventilation asymmetry
    • Lambert AR, O'Shaughnessy PT, Tawhai MH, Hoffman EA, Lin CL. Regional deposition of particles in an imaged-based airway model: largeeddy simulation and left-right lung ventilation asymmetry. Aerosol Sci Technol 45:11-25, 2011.
    • (2011) Aerosol Sci Technol , vol.45 , pp. 11-25
    • Lambert, A.R.1    O'Shaughnessy, P.T.2    Tawhai, M.H.3    Hoffman, E.A.4    Lin, C.L.5
  • 20
    • 0031791013 scopus 로고    scopus 로고
    • Time to peak insulin level, relative bioavailability, and effect of site of deposition of nebulized insulin in patients with noninsulin-dependent diabetes mellitus
    • Laube BL, Benedict GW, Dobs AS. Time to peak insulin level, relative bioavailability, and effect of site of deposition of nebulized insulin in patients with non-insulin-dependent diabetes mellitus. J Aerosol Med 11:153-173, 1998. (Pubitemid 28485303)
    • (1998) Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung , vol.11 , Issue.3 , pp. 153-173
    • Laube, B.L.1    Benedict, G.W.2    Dobs, A.S.3
  • 21
    • 33845600916 scopus 로고    scopus 로고
    • Validating CFD predictions of respiratory aerosol deposition: Effects of upstream transition and turbulence
    • DOI 10.1016/j.jbiomech.2006.01.006, PII S0021929006000285
    • Longest PW, Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. J Biomech 40:305-316, 2007. (Pubitemid 44958582)
    • (2007) Journal of Biomechanics , vol.40 , Issue.2 , pp. 305-316
    • Worth Longest, P.1    Vinchurkar, S.2
  • 22
    • 58549098521 scopus 로고    scopus 로고
    • CFD simulation of aerosol deposition in an anatomically based human large-medium airway model
    • Ma B, Lutchen KR. CFD simulation of aerosol deposition in an anatomically based human large-medium airway model. Ann Biomed Eng 37:271-285, 2008.
    • (2008) Ann Biomed Eng , vol.37 , pp. 271-285
    • Ma, B.1    Lutchen, K.R.2
  • 24
    • 0038383772 scopus 로고    scopus 로고
    • Deposition and effects of inhaled corticosteroids
    • Newman SP. Deposition and effects of inhaled corticosteroids. Clin Pharmacokinet 42:529-544, 2003. (Pubitemid 36801871)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.6 , pp. 529-544
    • Newman, S.P.1
  • 25
    • 0037855989 scopus 로고    scopus 로고
    • Computational fluid dynamics simulations of airflow and aerosol deposition in human lungs
    • Nowak N, Kakade PP, Annapragada AV. Computational fluid dynamics simulations of airflow and aerosol deposition in human lungs. Ann Biomed Eng 31:374-390, 2003.
    • (2003) Ann Biomed Eng , vol.31 , pp. 374-390
    • Nowak, N.1    Kakade, P.P.2    Annapragada, A.V.3
  • 27
    • 0025181487 scopus 로고
    • Dose-response effects of two sizes of monodisperse isoproterenol in mild asthma
    • Patel P, Mukai D, Wilson AF. Dose-response effects of two sizes of monodisperse isoproterenol in mild asthma. Am Rev Respir Dis 141:357-360, 1990. (Pubitemid 20068874)
    • (1990) American Review of Respiratory Disease , vol.141 , Issue.2 , pp. 357-360
    • Patel, P.1    Mukai, D.2    Wilson, A.F.3
  • 28
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • DOI 10.1016/0169-409X(95)00113-L
    • Patton JS. Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev 19:3-36, 1996. (Pubitemid 26167852)
    • (1996) Advanced Drug Delivery Reviews , vol.19 , Issue.1 , pp. 3-36
    • Patton, J.S.1
  • 29
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • DOI 10.1038/nrd2153, PII NRD2153
    • Patton JS, Byron PR. Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67-74, 2007. (Pubitemid 46020287)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 31
    • 77249145317 scopus 로고    scopus 로고
    • CFD simulation of particle deposition in a reconstructed human oral extrathoracic airway for air and helium-oxygen mixtures
    • Sandeau J, Katz I, Fodil R, Apiou-Sbirlea G, Caillibotte G, Isabey D. CFD simulation of particle deposition in a reconstructed human oral extrathoracic airway for air and helium-oxygen mixtures. J Aerosol Sci 41:281-294, 2010.
    • (2010) J Aerosol Sci , vol.41 , pp. 281-294
    • Sandeau, J.1    Katz, I.2    Fodil, R.3    Apiou-Sbirlea, G.4    Caillibotte, G.5    Isabey, D.6
  • 32
    • 0015317281 scopus 로고
    • Particle deposition in casts of the human upper tracheobronchial tree
    • Schlesinger RB, Lippmann M. Particle deposition in casts of the human upper tracheobronchial tree. Am Ind Hyg Assoc J 33:237-251, 1972.
    • (1972) Am Ind Hyg Assoc J , vol.33 , pp. 237-251
    • Schlesinger, R.B.1    Lippmann, M.2
  • 33
    • 0034019232 scopus 로고    scopus 로고
    • On the suitability of k-κ turbulence modeling for aerosol deposition in the mouth and throat: A comparison with experiment
    • DOI 10.1016/S0021-8502(99)00547-9, PII S0021850299005479
    • Stapelton KW, Guentsch E, Hoskinson MK, Finlay WH. On the suitability of the κ-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment. J Aerosol Sci 31:739-749, 2000. (Pubitemid 30173204)
    • (2000) Journal of Aerosol Science , vol.31 , Issue.6 , pp. 739-749
    • Stapleton, K.W.1    Guentsch, E.2    Hoskinson, M.K.3    Finlay, W.H.4
  • 34
    • 0002125271 scopus 로고
    • Gas transport in the conducting airways
    • edited by Engel LA, Paiva M. New York: Dekker
    • Ultman J. Gas transport in the conducting airways. In: Gas Mixing and Distribution in the Lung, edited by Engel LA, Paiva M. New York: Dekker, 1985, p. 63-136.
    • (1985) Gas Mixing and Distribution in the Lung , pp. 63-136
    • Ultman, J.1
  • 36
    • 14144252639 scopus 로고    scopus 로고
    • Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics
    • DOI 10.1152/japplphysiol.00795.2004
    • van Ertbruggen C, Hirsch C, Paiva M. Anatomically based threedimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol 98:970-980, 2005. (Pubitemid 40283678)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.3 , pp. 970-980
    • Van Ertbruggen, C.1    Hirsch, C.2    Paiva, M.3
  • 37
    • 0025853379 scopus 로고
    • Ventilation agents-what agents are currently used?
    • White PG, Hayward WJ, Cooper T. Ventilation agents-what agents are currently used? Nucl Med Commun 12:349-352, 1991.
    • (1991) Nucl Med Commun , vol.12 , pp. 349-352
    • White, P.G.1    Hayward, W.J.2    Cooper, T.3
  • 38
    • 49649085066 scopus 로고    scopus 로고
    • Effects of the laryngeal jet on nanoand microparticle transport and deposition in an approximate model of the upper tracheobronchial airways
    • Xi J, Longest PW, Martonen TB. Effects of the laryngeal jet on nanoand microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. J Appl Physiol 104:1761-1777, 2008.
    • (2008) J Appl Physiol , vol.104 , pp. 1761-1777
    • Xi, J.1    Longest, P.W.2    Martonen, T.B.3
  • 39
    • 0028298466 scopus 로고
    • The optimal particle size for β-adrenergic aerosols in mild asthmatics
    • DOI 10.1016/0378-5173(94)90436-7
    • Zanen P, Go LT, Lammers J W J. The optimal particle size for β-adrenergic aerosols in mild asthmatics. Int J Pharm 107:211-217, 1994. (Pubitemid 24182106)
    • (1994) International Journal of Pharmaceutics , vol.107 , Issue.3 , pp. 211-217
    • Zanen, P.1    Go, L.T.2    Lammers, J.-W.J.3
  • 40
    • 28144446599 scopus 로고    scopus 로고
    • Balloon-facilitated percutaneous dilatational tracheostomy tube placement
    • Zgoda MA, Berger R. Balloon-facilitated percutaneous dilatational tracheostomy tube placement. Chest 128:3688-3690, 2005.
    • (2005) Chest , vol.128 , pp. 3688-3690
    • Zgoda, M.A.1    Berger, R.2
  • 41
    • 29844458412 scopus 로고    scopus 로고
    • Experimental measurements of particle deposition in three proximal lung bifurcation models with an idealized mouth-throat
    • DOI 10.1089/jam.2005.18.460
    • Zhang Y, Finlay WH. Experimental measurements of particle deposition in three proximal lung bifurcation models with an idealized mouth-throat. J Aerosol Med 18:460-473, 2005. (Pubitemid 43038411)
    • (2005) Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung , vol.18 , Issue.4 , pp. 460-473
    • Zhang, Y.1    Finlay, W.H.2
  • 42
    • 22244445130 scopus 로고    scopus 로고
    • Particle deposition in a cast of human tracheobronchial airways
    • DOI 10.1080/027868291001385
    • Zhou Y, Cheng YS. Particle deposition in a cast of human tracheobronchial airways. Aerosol Sci Technol 39:492-500, 2005. (Pubitemid 40993227)
    • (2005) Aerosol Science and Technology , vol.39 , Issue.6 , pp. 492-500
    • Zhou, Y.1    Cheng, Y.-S.2


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