Preoperative Anemia is Associated With Worse Long-Term Survival After Lung Cancer Resection: A Multicenter Cohort Study of 5,029 Patients

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 36, Issue 5, 2022, Pages 1373-1379

  Taylor, Marcus ^a   Abah, Udo ^b   Hayes, Tim ^a   Eadington, Thomas ^a   Smith, Matthew ^b   Shackcloth, Michael ^b   Granato, Felice ^a   Shah, Rajesh ^a   Booton, Richard ^a   Grant, Stuart W ^c  

^a WYTHENSHAWE HOSPITAL   (United Kingdom)

^b LIVERPOOL HEART AND CHEST HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

90 day mortality; anemia; non small cell lung cancer; survival; thoracic surgery

Indexed keywords

HEMOGLOBIN;

AGED; ANEMIA; ARTICLE; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVAL; CLINICAL OUTCOME; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; LONG TERM SURVIVAL; LUNG CANCER; LUNG LOBECTOMY; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREOPERATIVE EVALUATION; PREOPERATIVE PERIOD; RETROSPECTIVE STUDY; SURGICAL MORTALITY; CLINICAL TRIAL; COMPLICATION; LUNG; LUNG TUMOR; MULTICENTER STUDY; RISK FACTOR;

ANEMIA; COHORT STUDIES; FEMALE; HEMOGLOBINS; HUMANS; LUNG; LUNG NEOPLASMS; MALE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 85124150410     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2021.08.029     Document Type: Article

References (29)

1. National Cancer Registration & Analysis Service (NCRAS). Chemotherapy, Radiotherapy and Tumour Resections in England: 2013-2015.Available at https://www.ncin.org.uk/cancer_type_and_topic_specific_work/topic_specific_work/main_cancer_treatments. Accessed March 1, 2021.
2. Liu, Y, Bai, YP, Zhou, ZF, et al. Preoperative anemia as a prognostic factor in patients with lung cancer: A systematic review and meta-analysis of epidemiological studies. J Cancer 10 (2019), 2047–2056.
3. Cata, JP, Chukka, V, Wang, H, et al. Perioperative blood transfusions and survival in patients with non-small cell lung cancer: A retrospective study. BMC Anesthesiol, 13, 2013, 42.
4. Tomita, M, Shimizu, T, Hara, M, et al. Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients. Anticancer Res 28 (2008), 1947–1950.
5. Chamogeorgakis, T, Anagnostopoulos, C, Kostopanagiotou, G, et al. Does anemia affect outcome after lobectomy or pneumonectomy in early stage lung cancer patients who have not received neo-adjuvant treatment?. Thorac Cardiovasc Surg 56 (2008), 148–153.
6. Panagopoulos, ND, Karakantza, M, Koletsis, E, et al. Influence of blood transfusions and preoperative anemia on long-term survival in patients operated for non-small cell lung cancer. Lung Cancer 62 (2008), 273–280.
7. Berardi, R, Brunelli, A, Tamburrano, T, et al. Perioperative anemia and blood transfusions as prognostic factors in patients undergoing resection for non-small cell lung cancers. Lung Cancer 49 (2005), 371–376.
8. Yovino, S, Kwok, Y, Krasna, M, et al. An association between preoperative anemia and decreased survival in early-stage non-small-cell lung cancer patients treated with surgery alone. Int J Radiat Oncol Biol Phys 62 (2005), 1438–1443.
9. Rzyman, W, Dziadziuszko, R, Skokowski, J, et al. The influence of blood transfusion on survival in operated non-small cell lung cancer patients. J Thorac Cardiovasc Surg 126 (2003), 755–760.
10. Jazieh, AR, Hussain, M, Howington, JA, et al. Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer. Ann Thorac Surg 70 (2000), 1168–1171.
11. Ng, T, Ryder, BA, Chern, H, et al. Leukocyte-depleted blood transfusion is associated with decreased survival in resected early-stage lung cancer. J Thorac Cardiovasc Surg 143 (2012), 815–819.
12. Jean, RA, Deluzio, MR, Kraev, AI, et al. Analyzing risk factors for morbidity and mortality after lung resection for lung cancer using the NSQIP database. J Am Coll Surg 222 (2016), 992–1000.
13. World Health Organization (WHO). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. (WHO/NMH/NHD/MNM/11.1). Available at https://www.who.int/vmnis/indicators/haemoglobin. Accessed March 1, 2021.
14. Anile, M, Venuta, F, Diso, D, et al. Preoperative anaemia does not affect the early postoperative outcome in patients with lung cancer. Minerva Chir 62 (2007), 431–435.
15. Taylor, M, Hashmi, SF, Martin, GP, et al. A systematic review of risk prediction models for perioperative mortality after thoracic surgery. Interact Cardiovasc Thorac Surg 32 (2021), 333–342.
16. Fowler, AJ, Ahmad, T, Phull, MK, et al. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg 102 (2015), 1314–1324.
17. Melis, M, McLoughlin, JM, Dean, EM, et al. Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer. J Surg Res 153 (2009), 114–120.
18. Wilson, MJ, van Haaren, M, Harlaar, JJ, et al. Long-term prognostic value of preoperative anemia in patients with colorectal cancer: A systematic review and meta-analysis. Surg Oncol 26 (2017), 96–104.
19. Martin-Loeches, M, Ortí, RM, Asins, E, et al. The prognostic implications of anaemia in the outcome of patients with early stages of uterine cervix carcinoma. Arch Gynecol Obstet 267 (2003), 121–125.
20. van de Pol, SMG, Doornaert, PAH, De Bree, R, et al. The significance of anemia in squamous cell head and neck cancer treated with surgery and postoperative radiotherapy. Oral Oncol 42 (2006), 131–138.
21. Madeddu, C, Gramignano, G, Astara, G, et al. Pathogenesis and treatment options of cancer related anemia: Perspective for a targeted mechanism-based approach. Front Physiol, 9, 2018, 1294.
22. National Institute for Health and Care Excellence (NICE). Erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy. NICE Guideline TA323, March 1, 2021 Available at https://www.nice.org.uk/guidance/ta323.
23. Goodnough, LT, Skikne, B, Brugnara, C., Erythropoietin, iron, and erythropoiesis. Blood 96 (2000), 823–833.
24. Gagné, S, McIsaac, DI., Modifiable risk factors for patients undergoing lung cancer surgery and their optimization: A review. J Thorac Dis 10 (2018), S3761–S3772.
25. Richards, T, Baikady, RR, Clevenger, B, et al. Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): A randomised, double-blind, controlled trial. Lancet 396 (2020), 1353–1361.
26. Batchelor, TJP, Rasburn, NJ, Abdelnour-Berchtold, E, et al. Guidelines for enhanced recovery after lung surgery: Recommendations of the Enhanced Recovery after Surgery (ERAS) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg 55 (2019), 91–115.
27. Muñoz, M, Acheson, AG, Auerbach, M, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia 72 (2017), 233–247.
28. Karkouti, K, Wijeysundera, DN, Beattie, WS., Risk associated with preoperative anemia in cardiac surgery: A multicenter cohort study. Circulation 117 (2008), 478–484.
29. Hung, M, Ortmann, E, Besser, M, et al. A prospective observational cohort study to identify the causes of anaemia and association with outcome in cardiac surgical patients. Heart 101 (2015), 107–112.