A prospective observational cohort study to identify the causes of anaemia and association with outcome in cardiac surgical patients

Heart

Volumn 101, Issue 2, 2015, Pages 107-112

  Hung, Matthew ^a   Ortmann, Erik ^a   Besser, Martin ^b   Martin Cabrera, Pedro ^b   Richards, Toby ^c   Ghosh, Marcus ^a   Bottrill, Fiona ^a   Collier, Timothy ^d   Klein, Andrew A ^a  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HEPCIDIN; IRON;

AGED; ANEMIA; ARTICLE; BLOOD ANALYSIS; BONE MARROW; COHORT ANALYSIS; CORONARY ARTERY BYPASS GRAFT; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HEART VALVE SURGERY; HUMAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; BLOOD; BLOOD TRANSFUSION; BONE MARROW EXAMINATION; DEFICIENCY; HEART DISEASES; METABOLISM; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; PROCEDURES; RISK FACTOR; STATISTICS; UNITED KINGDOM;

AGED; ANEMIA; BLOOD TRANSFUSION; BONE MARROW EXAMINATION; CARDIAC SURGICAL PROCEDURES; COHORT STUDIES; FEMALE; GREAT BRITAIN; HEART DISEASES; HEMOGLOBINS; HEPCIDINS; HUMANS; IRON; MALE; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; RISK FACTORS; STATISTICS AS TOPIC;

EID: 84920537438     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2014-305856     Document Type: Article

References (29)

1. Hung M, Besser M, Sharples LD, et al. The prevalence and association with transfusion, intensive care unit stay and mortality of preoperative anaemia in a cohort of cardiac surgery patients. Anaesthesia 2011;66:812-18.
2. World Health Organisation. Nutritional anaemias: Report of a WHO Scientific Group. Geneva, Switzerland: World Health Organisation, 1968. http://whqlibdoc.who.int/trs/WHO-TRS-405.pdf (accessed 13 Nov 2013).
3. The Society for Cardiothoracic Surgery in Great Britain and Ireland. Sixth National Adult Cardiac Surgical Database Report 2008: Demonstrating Quality. http://www.scts.org/-userfiles/resources/SixthNACSDreport2008withcovers.pdf (accessed 13 Nov 2013).
4. Loor G, Koch CG, Sabik JF III, et al. Implications and management of anemia in cardiac surgery: current state of knowledge. J Thorac Cardiovasc Surg 2012;144:538-46.
5. Karkouti K, Wijeysundera D, Beattie W, et al. Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation 2008;117:478-84.
6. Goodnough LT, Levy JH, Murphy MF. Concepts of blood transfusion in adults. Lancet 2013;381:1845-54.
7. Anker SD, Comin Colet J, Filippatos G, et al.; FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009;361:2436-48.
8. Ranucci M, Baryshnikova E, Castelvecchio S, et al. Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Ann Thorac Surg 2013;96:478-85.
9. Bregman DB, Morris D, Koch TA, et al. Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am J Hematol 2013;88:97-101.
10. Cladellas M, Farre N, Comin-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol 2012;110:1021-6.
11. Thomas DW, Hinchliffe RF, Briggs C, et al. British Committee for Standards in Haematology. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haem 2013;161:639-48.
12. Nashef SA, Roques F, Sharples LD, et al. EuroSCORE II. Eur J Cardiothorac Surg 2012;41:734-44.
13. Ariti CA, Cleland JG, Pocock SJ, et al. Days alive and out of hospital and the patient journey in patients with heart failure: Insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. Am Heart J 2011;162:900-6.
14. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004;104:2263-8.
15. Patel KV. Epidemiology of anemia in older adults. Semin Hematol 2008;45:210-17.
16. Williams ML, He X, Rankin JS, et al. Preoperative haematocrit is a powerful predictor of adverse outcomes in coronary artery bypass surgery: a report from the Society of Thoracic Surgeons adult cardiac surgery database. Ann Thorac Surg 2013;96:1628-34.
17. Van Straten AH, Hamad MA, van Zundert AJ, et al. Preoperative hemoglobin level as a predictor of survival after coronary artery bypass grafting: a comparison with the matched general population. Circulation 2009;120:118-25.
18. Avni T, Leibovici L, Gafter-Gvili A. Iron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis. Eur J Heart Failure 2012;14:423-9.
19. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials. BMJ 2013;347:f4822.
20. Opasich C, Cazzola M, Scelsi L, et al. Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. Eur Heart J 2005;26:2232-7.
21. Beck-da-Silva L, Piardi D, Soder S, et al. IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia. Int J Card 2013;168:3439-42.
22. Silverberg DS, Blum M, Agbaria Z, et al. The effect of i.v. iron alone or in combination with low-dose erythropoietin in the rapid correction of anemia of chronic renal failure in the predialysis period. Clin Nephrol 2001;55:212-19.
23. Dec GW. Anemia in heart failure time to rethink its etiology and treatment? J Am Coll Cardiol 2006;48:2490-2.
24. Gartlehner G, Flamm M. Is The Cochrane Collaboration prepared for the era of patient-centred outcomes research? [editorial]. Cochrane Database of Systematic Reviews 2013;3:ED000054.
25. Musallam KM, Tamim HM, Richards T, et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 2011;378:1396-407.
26. Prowle JR, Ostland V, Calzavacca P, et al. Greater increase in urinary hepcidin predicts protection from acute kidney injury after cardiopulmonary bypass. Nephrol Dial Transplant 2012;27:595-602.
27. Haase-Fielitz A, Plainnodatabeta M, Kuppe H, et al. Low preoperative hepcidin concentration as a risk factor for mortality after cardiac surgery: a pilot study. J Thorac Cardiovasc Surg 2013;145:1380-6.
28. Hajjar LA, Vincent JL, Galas FR, et al. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 2010;304:1559-67.
29. Nemeth E. Anti-hepcidin therapy for iron-restricted anemias. Blood 2013;122:2929-31.