Preparation of sustained-release matrix tablets of aspirin with ethylcellulose, eudragit rs100 and eudragit s100 and studying the release profiles and their sensitivity to tablet hardness

Iranian Journal of Pharmaceutical Research

Volumn 2, Issue 4, 2003, Pages 201-206

  Tabandeh, Hosseinali ^a   Mortazavi, Seyed Alireza ^a   Guilani, Tina Bassir ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aspirin; Ethylcellulose; Eudragit; Hardness; Matrix tablet; Release rate; Sustained release

Indexed keywords

EID: 85111611373     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/ijpr.2010.56     Document Type: Article

References (14)

1. Plaizier-Vercammen J, Dauwe D and Brioen P. Possibility of the use of Eudragit RS as a sustained-release matrix agent for the incorporation of water-soluble active compounds at high percentages. STP Pharma. Sci. (1997) 7: 491-497
2. Jayaswa, SB, Gode KD and Khanna SK. Sustained release tablet formulation of propranolol hydrochloride with Eudragit. Aust. J. Pharm. Sci. (1980) 9: 22-26
3. Jovanovic M, Jovicic G, Djuric Z, Agbaba D, Karljikovic-Rajic K, Nikolic L and Radovanovic J. Influence of Eudragit type on the dissolution rate of acetylsalicylic acid from matrix tablets. Acta Pharm. Hung. (1997) 67: 229-234
4. Makhija SN and Vavia PR. Once daily sustained release tablets of venlafaxine, a novel antidepressant. Eur. J. Pharm. Biopharm. (2002) 54: 9-15
5. Katikaneni PR, Upadrashta SM, Neau SH and Mitra AK. Ethylcellulose matrix controlled release tablets of a water-soluble drug. Int. J. Pharm. (1995) 123: 119-125
6. Shlieout G and Zessin G. Investigation of ethylcellulose as a matrix former and a new method to regard and evaluate the compaction data. Drug Dev. Ind. Pharm. (1996) 22: 313-319
7. Pollock DK and Sheskey PJ. Micronized ethylcellulose: opportunities in direct-compression controlled-release tablets. Pharm. Tech. (1996) 20: 120-130
8. Pather I, Russell I, Syce JA and Neau SH. Sustained release theophyline tablets by direct compression, Part 1: formulation and in vitro testing. Int. J. Pharm. (1998) 164: 1-10
9. Upadrashta SM, Katikaneni PR, Hileman GA and Keshary PR. Direct compression controlled release tablets using ethylcellulose matrices. Drug Dev. Ind. Pharm. (1993) 199: 449-460
10. Stamm A and Tritsch JC. Some considerations on the liberation of drugs from inert matrices. Drug Dev. Ind. Pharm. (1986) 12: 2337-2353
11. Neau SH, Howard MA, Claudius JS and Howard DR. The effect of the aqueous solubility of xanthine derivatives on the release mechanism from ethylcellulose matrix tablets. Int. J. Pharm. (1999) 179: 97-105
12. th ed. U.S. Pharmacopoeial Convention, Rockville (2000) 167-168
13. Sanchez-Lafuente C, Faucci MT, Fernandez-Arevalo M, Alvarez-Fuentes J, Rabasco AM and Mura P. Development of sustained release tablets of didanosine containing methacrylic and ethylcellulose polymers. Int. J. Pharm. (2002) 234: 213-221
14. Jovanovic M, Jokic D, Duric Z, Tasic L and Jovicic G. Preparation and preliminary evaluation of sustained-release acetylsalicylic acid tablets. Pharmazie (1990) 45: 869