Sustained release theophylline tablets by direct compression Part 1: Formulation and in vitro testing

International Journal of Pharmaceutics

Volumn 164, Issue 1-2, 1998, Pages 1-10

  Pather, S Indiran ^a,b   Russell, Irina ^a   Syce, James A ^a   Neau, Steven H ^b  

^a UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Erosion; Ethylcellulose; Mathematical modeling; Matrix tablets; Polymeric retardants; Sustained release; Theophylline

Indexed keywords

ETHYL CELLULOSE; POLYMER; THEOPHYLLINE;

ARTICLE; COMPRESSION; CONTROLLED STUDY; DISSOLUTION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUTION; IN VITRO STUDY; MATHEMATICAL MODEL; MATRIX TABLET; MOISTURE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; SURFACE PROPERTY; SUSTAINED RELEASE FORMULATION; TABLET; TABLET FORMULATION; TABLET HARDNESS; TABLET MANUFACTURE;

EID: 0032513508     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00348-7     Document Type: Article

References (19)

1. Allen, T., 1968. Particle Size Measurement. In: Williams, J.C. (Ed.), Powder Technology Series. Chapman and Hall, London.
2. Anonymous, 1987. Profitability in a changing market: the new realities of pharmaceutical manufacturing. Aerosol Age 32 (9), 28-29.
3. Banker, G.S., Anderson, N.R., 1986. Tablets. In: Lachman, L., Lieberman, H.A., Kanig, J.L. (Eds.), The Theory and Practice of Industrial Pharmacy. 3rd ed. Lea and Febiger, Philadelphia, PA.
4. Bolhuis G.K., Lerk C.F., Zijlstra H.T., de Boer A.H. Film formation by magnesium stearate during mixing and its effect on tabletting. Pharm. Weekbl. 110:1975;317-325.
5. Brossard C., Lefort des Ylouses D., Duchene D., Puisieux F., Carstensen J.T. Dissolution of a soluble drug substance from vinyl polymer matrices. J. Pharm. Sci. 72:1983;162-169.
6. Draper, N., Smith, H., 1981. Applied Regression Analysis, 2nd ed. Wiley, New York.
7. Fassihi A.R. Continuous matrix formation for controlled drug release: compression of isotropic polymeric system. Int. J. Pharm. 34:1986;169-172.
8. Hendeles L., Weinberger M., Johnson G. Monitoring serum theophylline levels. Clin. Pharmacokinet. 3:1978;294-312.
9. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52:1963;1145-1149.
10. Jarosz P.J., Parrott E.L. Effect of lubricants on tensile strengths of tablets. Drug Dev. Ind. Pharm. 10:1984;259-273.
11. Lerk C.F., Bolhuis G.K. Interaction of lubricants and colloidal silica during mixing with excipients II. Its effect on wettability and dissolution velocity. Pharm. Acta Helv. 52:1977;39-44.
12. Lerk C.F., Schoonen A.J.M., Fell J.T. Contact angles and wetting of pharmaceutical powders. J. Pharm. Sci. 65:1976;843-847.
13. Lerk C.F., Bolhuis G.K., Smedema S.S. Interaction of lubricants and colloidal silica during mixing with excipients. Pharm. Acta Helv. 52:1977;33-39.
14. Marshall, K., 1986. Compression and consolidation of powdered solids. In: Lachman, L., Lieberman, H.A., Kanig, J.L. (Eds.), The Theory and Practice of Industrial Pharmacy, 3rd ed. Lea and Febiger, Philadelphia, PA.
15. Ragnarsson G., Holzer A.W., Sjogren J. The influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate. Int. J. Pharm. 3:1979;127-131.
16. Sheth, B.B., Bandelin, F.J., Shangraw, R.F., 1980. Compressed tablets by direct compression. In: Lieberman, H.A., Lachman, L. (Eds.), Pharmaceutical Dosage Forms: Tablets, vol. 1. Marcel Dekker, New York.
17. Upadrashta S.M., Katikaneni P.R., Hileman G.A., Keshary P.R. Direct compression controlled release tablets using ethylcellulose matrices. Drug Dev. Ind. Pharm. 19:1993;449-460.
18. Van der Watt J.G. The effect of the particle size of microcrystalline cellulose on tablet properties in mixtures with magnesium stearate. Int. J. Pharm. 36:1987;51-54.
19. Wadke, D.A., Jacobson, H., 1980. Preformulation testing. In: Lieberman, H.A., Lachman, L. (Eds.), Pharmaceutical Dosage Forms: Tablets, vol. 1. Marcel Dekker, New York.