Determination of 18 β-glycyrrhetinic acid in glycyrrhiza glabra l. Extract by hplc

Iranian Journal of Pharmaceutical Research

Volumn 5, Issue 2, 2006, Pages 137-141

  Esmaeili, Somayeh ^a   Naghibi, Farzaneh ^a   Mosaddegh, Mahmoud ^a   Nader, Nazli ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

18 Glycyrrhetinic acid; Glycyrrhiza glabra; High performance liquid chromatography (HPLC); Thin layer chromatography (TLC)

Indexed keywords

EID: 85111417989     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/IJPR.2010.666     Document Type: Article

References (25)

1. Gibson MR. Glycyrrhizin in old and new perspectives. Lloydia (1978) 41: 348-354
2. Baker ME. Endocrine activity of plant-derived compounds: an evolutionary perspective. Proc. Soc. Exp. Biol. Med. (1995) 208: 131-138
3. Norman HA, Pillai P and Baker ME. Licorice-derived compounds inhibit linoleic acid desaturation in soybean chloroplasts. FEBS Letters (1995) 368: 135-138
4. DerMarderosian A. The Review of Natural Products, Facts and Comparisons, Illinoise (2001) 369-370
5. Blumenthal M and Busse W R. The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines, American Botanical Council, Austin (1998) 161
6. Lauren DR, Jensen DJ, Douglas JA and Follett JM. Efficient method for determining the glycyrrhizin content of fresh and dried roots, and root extracts, of Glycyrrhiza species. Phytochem. Anal. (2001) 12: 332-5
7. Liu S, Jiang X, Zheng Y and Xu P. Determination of glycyrrhizin in Glycyrrhiza and it’s preparations by ion-pair HPLC. Hua Xi Yi Ke Da Xue Xue Bao. (1993) 24: 111-4
8. Kitagawa I, Chen WZ, Taniyama T, Harada E, Hori K, Kobayashi M and Ren J. Quantitative determination of constituents in various licorice roots by means of high performance liquid chromatography. Yakugaku Zasshi (1998) 118: 519-28
9. Zeng L, Zhang RY and Lou ZC. Separation and quantitative determination of three saponins in licorice root by high performance liquid chromatography. Yao Xue Xue Bao. (1991) 26: 53-8
10. Andrisano V, Bonazzi D and Cavrini V. HPLC analysis of liquorice triterpenoids--applications to the quality control of pharmaceuticals. J. Pharm. Biomed. Anal. (1995) 13: 597-605
11. Russel FG, van Uum S, Tan Y and Smits P. Solid-phase extraction of 18 beta-glycyrrhetinic acid from plasma and subsequent analysis by high-performance liquid chromatography. J. Chromatogr. B, Biomed. Sci. Appl. (1998) 12; 710(1-2): 223-6
12. Killacky J, Ross MS and Turner TD. The determination of beta-glycyrrhetinic acid in liquorice by high pressure liquid chromatography. Planta Med. (1976) 30: 310-6
13. Sabbioni C, Ferranti A, Bugamelli F, Forti GC and Raggi MA. Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products. Phytochem. Anal. (2005) 17: 25-31
14. Tomono S, SeoY, Yukawa N, Matsuda H and Takahama K. Glycyrrhizin and glycyrrhetinic acid determination from formalin-fixed tissue. Int. J. Legal Med. (1992) 104: 321-324
15. Okamura N, Maki T, Miyauchi H, Shimoe M, Yokono S, Yoshitomi H and Yagi A. Simultaneous determination of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide in Shakuyaku-kanzo-to incubated with rat feces by semi-micro high-performance liquid chromatography. Biol. Pharm. Bull. (2001) 24: 1161-4
16. Raggi MA, Bugamelli F, Nobile L, Schiavone P and Cantelli-Forti G. HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats. Boll. Chim. Farm. (1994) 133: 704-8.
17. Guillaume CP, van der Molen JC, Kerstens MN, Dullaart RP and Wolthers BG. Determination of urinary 18 beta-glycyrrhetinic acid by gas chromatography and its clinical application in man. J. Chromatogr. B,
18. Biomed. Sci. Appl. (1999) 20;731(2): 323-34 Yang J, Han G, Feng L, Dai J, Xu R, Cai M, Zhao M, Meng J. Determination of glycyrrhetinic acid in radix Glycyrrhizae by TLC densitometry. Zhongguo Zhong
19. Yao Za Zhi. (1991) 16: 232-4, 255 Chen HR and Sheu SJ. Determination of glycyrrhizin and glycyrrhetinic acid in traditional Chinese medicinal preparations by capillary electrophoresis. J.
20. Chromatogr. A (1993) 653: 184-188 Andrisano V, Bonazzi D and Cavrini V. HPLC Analysis of liquorice triterpenoids applications to the quality control of Pharmaceuticals. J. Pharm. Biomed. Anal.
21. (1995) 13: 597-605 Afshar J and Delazar A. Quantitative determination of glycyrrhizin and glycyrrhetic acid in roots of liquorice by HPLC. Journal of the School of Pharmacy, Tehran
22. University of Medical Sciences (1992) 2: 229-236 Shimadzu high performance liquid chromatography
23. pharmaceutical application data. Tokyo.77. ICH-Guideline Q 2A, Validation of Analytical Procedures: Definition and Trminology, http://www.
24. fda.gov/cder/guidance/ichq2a.pdf (access: July 2006). ICH-Guideline Q 2B, Validation of Analytical Procedures: Methodology, http://www.fda.gov/cber/
25. gdlns/ichq2bmeth.pdf (access: July 2006). Gao QT, Chen XH and Bi KS. Comparetive pharmacokinetic bBehavior of glycyrrhetinic acid after oral administration of glycyrrhizic acid and Gancao Fuzi-Tang. Biol. Pharm. Bull. (2004) 27: 226-8