Association between Administration of Systemic Corticosteroids and Mortality among Critically Ill Patients with COVID-19: A Meta-analysis

JAMA - Journal of the American Medical Association

Volumn 324, Issue 13, 2020, Pages 1330-1341

  Sterne, Jonathan A C ^a,b   Murthy, Srinivas ^c   Diaz, Janet V ^d   Slutsky, Arthur S ^e   Villar, Jesús ^f,g   Angus, Derek C ^h   Annane, Djillali ⁱ   Azevedo, Luciano Cesar Pontes ^j,k   Berwanger, Otavio ^l   Cavalcanti, Alexandre B ^m   Dequin, Pierre Francois ^n,o   Du, Bin ^p   Emberson, Jonathan ^q,r   Fisher, David ^s   Giraudeau, Bruno ⁿ   Gordon, Anthony C ^t   Granholm, Anders ^u   Green, Cameron ^v   Haynes, Richard ^q,r   Heming, Nicholas ⁱ   Higgins, Julian P T ^a,b,w   Horby, Peter ^x   Jüni, Peter ^e   Landray, Martin J ^q,r,y   Le Gouge, Amelie ⁿ   Leclerc, Marie ⁿ   Lim, Wei Shen ^z   Machado, Flávia R ^aa   McArthur, Colin ^v,ab   Meziani, Ferhat ^ac,ad   Møller, Morten Hylander ^u   Perner, Anders ^u   Petersen, Marie Warrer ^u   Savović, Jelena ^a,w   Tomazini, Bruno ^j,k   Veiga, Viviane C ^ae   Webb, Steve ^v,af   Marshall, John C ^e   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d WORLD HEALTH ORGANIZATION   (Switzerland)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^g INSTITUTO DE SALUD CARLOS III   (Spain)

^h UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITÉ PARIS SACLAY   (France)

^j HOSPITAL SÍRIO LIBANÊS   (Brazil)

^k UNIVERSITY OF SÃO PAULO   (Brazil)

^l HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^m Research Institute Cardiac Hospital (HCor)   (Brazil)

ⁿ UNIVERSITY HOSPITAL OF TOURS   (France)

^o UNIVERSITÉ DE TOURS   (France)

^p PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^q UNIVERSITY OF OXFORD   (United Kingdom)

^r UNIVERSITY OF OXFORD   (United Kingdom)

^s UNIVERSITY COLLEGE LONDON   (United Kingdom)

^t IMPERIAL COLLEGE LONDON   (United Kingdom)

^u UNIVERSITY OF COPENHAGEN   (Denmark)

^v MONASH UNIVERSITY   (Australia)

^w UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^x UNIVERSITY OF OXFORD   (United Kingdom)

^y OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^z NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^aa FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^ab AUCKLAND CITY HOSPITAL   (New Zealand)

^ac HÔPITAL CIVIL   (France)

^ad University of Strasbourg   (France)

^ae BENEFICÊNCIA PORTUGUESA DE SÃO PAULO   (Brazil)

^af St John of God Dermatology   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE; METHYLPREDNISOLONE; CORTICOSTEROID; GLUCOCORTICOID;

ARTICLE; ARTIFICIAL VENTILATION; CAUSE OF DEATH; CORONAVIRUS DISEASE 2019; CRITICALLY ILL PATIENT; DRUG EFFICACY; FOLLOW UP; HUMAN; INFORMED CONSENT; INTERVENTION STUDY; LIMIT OF QUANTITATION; MORTALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SAMPLE SIZE; SYSTEMATIC REVIEW; BETACORONAVIRUS; CORONAVIRUS INFECTION; CRITICAL ILLNESS; META ANALYSIS; PANDEMIC; RANDOMIZED CONTROLLED TRIAL (TOPIC); VIRUS PNEUMONIA;

ADRENAL CORTEX HORMONES; BETACORONAVIRUS; CAUSE OF DEATH; CORONAVIRUS INFECTIONS; CRITICAL ILLNESS; DEXAMETHASONE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; METHYLPREDNISOLONE; PANDEMICS; PNEUMONIA, VIRAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 85090909829     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2020.17023     Document Type: Article

References (26)

1. Dale DC, Petersdorf RG. Corticosteroids and infectious diseases. Med Clin North Am. 1973; 57 (5): 1277-1287. 4593200
2. Annane D, Bellissant E, Bollaert PE, Corticosteroids in the treatment of severe sepsis and septic shock in adults. JAMA. 2009; 301 (22): 2362-2375. 19509383
3. Annane D, Bellissant E, Bollaert PE, Corticosteroids for treating sepsis in children and adults. Cochrane Database Syst Rev. 2019; 12: CD002243. 31808551
4. Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020; 395 (10223): 473-475. 32043983
5. Villar J, Confalonieri M, Pastores SM, Meduri GU. Rationale for prolonged corticosteroid treatment in the acute respiratory distress syndrome caused by coronavirus disease 2019. Crit Care Explor. 2020; 2 (4): e0111. 32426753
6. Thomas J, Askie LM, Berlin JA, Chapter 22: prospective approaches to accumulating evidence. Accessed August 24, 2020. http://www.training.cochrane.org/handbook doi: 10.1002/9781119536604.ch22
7. Horby P, Lim WS, Emberson JR,; RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19-preliminary report. N Engl J Med. Published online July 17, 2020. doi: 10.1056/NEJMoa2021436 32678530
8. Sterne JAC, Diaz J, Villar J, Corticosteroid therapy for critically ill patients with COVID-19. Trials. Published online August 24, 2020. doi: 10.1186/s13063-020-04641-3
9. Ranieri VM, Rubenfeld GD, Thompson BT, Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012; 307 (23): 2526-2533. 22797452
10. Dequin PF, Heming N, Meziani F, Effect of hydrocortisone on 21-day mortality or respiratory support among critically ill patients with COVID-19: a randomized clinical trial. JAMA. Published online September 2, 2020. doi: 10.1001/jama.2020.16761
11. Sterne JAC, Savović J, Page MJ, RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366: l4898. 31462531
12. Guyatt GH, Oxman AD, Vist GE, GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336 (7650): 924-926. 18436948
13. Annane D, Pastores SM, Rochwerg B, Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (part I). Intensive Care Med. 2017; 43 (12): 1751-1763. 28940011
14. Paule RC, Mandel J. Consensus values and weighting factors. J Res. 1982; 87 (5): 377-385. doi: 10.6028/jres.087.022
15. Langan D, Higgins JPT, Simmonds M. Comparative performance of heterogeneity variance estimators in meta-analysis. Res Synth Methods. 2017; 8 (2): 181-198. 27060925
16. Hartung J, Knapp G. A refined method for the meta-analysis of controlled clinical trials with binary outcome. Stat Med. 2001; 20 (24): 3875-3889. 11782040
17. IntHout J, Ioannidis JP, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014; 14: 25. 24548571
18. Fisher DJ, Carpenter JR, Morris TP, Freeman SC, Tierney JF. Meta-analytical methods to identify who benefits most from treatments. BMJ. 2017; 356: j573. 28258124
19. Angus DC, Berry S, Lewis RJ, The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) study. Ann Am Thorac Soc. 2020; 17 (7): 879-891. 32267771
20. The Writing Committee for the REMAP-CAP Investigators. Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 Corticosteroid Domain randomized clinical trial. JAMA. Published online September 2, 2020. doi: 10.1001/jama.2020.17022
21. Tomazini BM, Maia IS, Cavalcanti AB, Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX randomized clinical trial. JAMA. Published online September 2, 2020. doi: 10.1001/jama.2020.17021
22. International Severe Acute Respiratory and Emerging Infections Consortium. COVID-19 report: 13 July 2020. Accessed August 11, 2020. https://media.tghn.org/medialibrary/2020/07/ISARIC_Data_Platform_COVID-19_Report_13JUL20.pdf
23. Jeronimo CMP, Farias MEL, Val FFA, Methylprednisolone as adjunctive therapy for patients hospitalized with COVID-19 (Metcovid). Clin Infect Dis. Published online August 12, 2020. doi: 10.1093/cid/ciaa1177 32785710
24. Docherty AB, Harrison EM, Green CA, Features of 20133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. BMJ. 2020; 369: m1985. 32444460
25. Abate SM, Ahmed Ali S, Mantfardo B, Basu B. Rate of intensive care unit admission and outcomes among patients with coronavirus. PLoS One. 2020; 15 (7): e0235653. 32649661
26. Lansbury LE, Rodrigo C, Leonardi-Bee J, Corticosteroids as adjunctive therapy in the treatment of influenza. Crit Care Med. 2020; 48 (2): e98-e106. 31939808