The effect of tranexamic acid on the values of activated clotting time in patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis

Journal of Clinical Anesthesia

Volumn 67, Issue , 2020, Pages

  Yao, Yun tai ^a   He, Li xian ^a   Tan, Jie chao ^b  

^a FUWAI HOSPITAL   (China)

^b SHUNDE HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Activated clotting time; Cardiac surgery; Meta analysis; Tranexamic acid

Indexed keywords

FRESH FROZEN PLASMA; HEPARIN; PROTAMINE; THROMBOCYTE CONCENTRATE; TRANEXAMIC ACID;

ACTIVATED CLOTTING TIME; ARTICLE; BLOOD CLOTTING TIME; BLOOD TRANSFUSION; DOSE RESPONSE; ERYTHROCYTE TRANSFUSION; HEART SURGERY; HEMODILUTION; HEPARINIZATION; HUMAN; META ANALYSIS; PEDIATRIC PATIENT; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SURGICAL PATIENT; SYSTEMATIC REVIEW;

EID: 85090029827     PISSN: 09528180     EISSN: 18734529     Source Type: Journal    
DOI: 10.1016/j.jclinane.2020.110020     Document Type: Article

References (35)

1. Hattersley, P.G., Activated coagulation time of whole blood. JAMA 196:5 (1966), 436–440.
2. Horton, S., Augustin, S., Activated clotting time (ACT). Methods Mol Biol 992 (2013), 155–167, 10.1007/978-1-62703-339-8_12.
3. Guzzetta, N.A., Monitz, H.G., Fernandez, J.D., Fazlollah, T.M., Knezevic, A., Miller, B.E., Correlations between activated clotting time values and heparin concentration measurements in young infants undergoing cardiopulmonary bypass. Anesth Analg 111:1 (2010), 173–179, 10.1213/ANE.0b013e3181e13470.
4. Baykut, D., Weichelt, K., Wehrle, J., Zerkowski, H.R., Bernet, F., The value of heparin concentration monitoring in off-pump coronary bypass surgery. Eur J Med Res 8:4 (2003), 161–164.
5. Despotis, G.J., Joist, J.H., Hogue, C.W. Jr., Alsoufiev, A., Kater, K., Goodnough, L.T., et al. The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 110:1 (1995), 46–54, 10.1016/S0022-5223(05)80008-X.
6. Lee, C.H., Tan, E., Wong, H.B., Tay, E., Tan, H.C., Impact of different Asian ethnic groups on correlation between heparin dose, activated clotting time and complications in percutaneous coronary intervention. Int J Cardiol 130:3 (2008), 500–502, 10.1016/j.ijcard.2007.07.017.
7. Koerber, J.M., Smythe, M.A., Begle, R.L., Mattson, J.C., Kershaw, B.P., Westley, S.J., Correlation of activated clotting time and activated partial thromboplastin time to plasma heparin concentration. Pharmacotherapy 19:8 (1999), 922–931, 10.1592/phco.19.11.922.31573.
8. Culliford, A.T., Gitel, S.N., Starr, N., Thomas, S.T., Baumann, F.G., Wessler, S., et al. Lack of correlation between activated clotting time and plasma heparin during cardiopulmonary bypass. Ann Surg 193:1 (1981), 105–111, 10.1097/00000658-198101000-00017.
9. Martindale, S.J., Shayevitz, J.R., D'Errico, C., The activated coagulation time: suitability for monitoring heparin effect and neutralization during pediatric cardiac surgery. J Cardiothorac Vasc Anesth 10:4 (1996), 458–463, 10.1016/s1053-0770(05)80004-7.
10. Zhu, Q., Yu, C., Chen, X., Xu, X., Chen, Y., Liu, C., et al. Efficacy and safety of tranexamic acid for blood salvage in intertrochanteric fracture surgery: a meta-analysis. Clin Appl Thromb Hemost 24:8 (2018), 1189–1198, 10.1177/1076029618783258.
11. Longo, M.A., Cavalheiro, B.T., de Oliveira Filho, G.R., Systematic review and meta-analyses of tranexamic acid use for bleeding reduction in prostate surgery. J Clin Anesth 48 (2018), 32–38, 10.1016/j.jclinane.2018.04.014.
12. Guo, J., Gao, X., Ma, Y., Lv, H., Hu, W., Zhang, S., et al. Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials. BMC Anesthesiol, 19(1), 2019, 129, 10.1186/s12871-019-0772-0.
13. Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ, 350, 2015, g7647, 10.1136/bmj.g7647.
14. Higgins, J.P., Altman, D.G., Gøtzsche, P.C., Jüni, P., Moher, D., Oxman, A.D., et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, 2011, d5928, 10.1136/bmj.d5928.
15. Lan, X., Liu, M.G., Chen, H.X., Liu, H.M., Zeng, W., Wei, D., et al. Efficacy of immunosuppression monotherapy after liver transplantation: a meta-analysis. World J Gastroenterol 20:34 (2014), 12330–12340, 10.3748/wjg.v20.i34.12330.
16. Yang, J.M., Zhang, C., Li, C.B., Huang, G.W., Yu, D.F., Tranexamic acid application in open heart valve replacement surgery. Chin J Mod Ope Sur 21:02 (2017), 117–120, 10.16260/j.cnki.1009-2188.2017.02.010.
17. Feng, J.L., Wu, H.J., Jiang, W.B., Li, Z., Zhang, J., Cheng, X.F., Study on the protective effect of tranexamic acid evaluated by thromboelastography in cardiopulmonary bypass. Acta Acad Med Weifang 37:06 (2015), 433–435, 10.3969/j.issn.1004-3101.2015.06.011.
18. Zhao, N., Zhang, D.M., Wang, M., Zhang, B., Effect of tranexamic acid on coagulation function and blood loss during perioperative valve replacement operation under cardiopulmonary bypass. J Ningxia Med Uni 36:05 (2014), 519–522, 10.16050/j.cnki.issn1674-6309.2014.05.026.
19. Aggarwal, V., Kapoor, P.M., Choudhury, M., Kiran, U., Chowdhury, U., Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair. Ann Card Anaesth 15:1 (2012), 26–31, 10.4103/0971-9784.91477.
20. Ahn, S.W., Shim, J.K., Youn, Y.N., Song, J.W., Yang, S.Y., Chung, S.C., et al. Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery. Circ J 76:1 (2012), 96–101, 10.1253/circj.cj-11-0811.
21. Wang, G., Xie, G., Jiang, T., Wang, Y., Wang, W., Ji, H., et al. Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo controlled study. Anesth Analg 115:2 (2012), 239–243, 10.1213/ANE.0b013e3182264a11.
22. Zhang, S.J., Zhu, D.M., Sheng, J., Wang, W., Zhang, W., The effects of tranexamic acid in pediatric extracorporeal circulation. Chin J ECC 8:03 (2010), 166–169, 10.13498/j.cnki.chin.j.ecc.2010.03.013.
23. Wei, M., Jian, K., Guo, Z., Wang, L., Jiang, D., Zhang, L., et al. Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting. Scand Cardiovasc J 40:2 (2006), 105–109, 10.1080/14017430500519864.
24. Bulutcu, F.S., Ozbek, U., Polat, B., Yalçin, Y., Karaci, A.R., Bayindir, O., Which may be effective to reduce blood loss after cardiac operations in cyanotic children: tranexamic acid, aprotinin or a combination?. Paediatr Anaesth 15:1 (2005), 41–46, 10.1111/j.1460-9592.2004.01366.x.
25. Chauhan, S., Das, S.N., Bisoi, A., Kale, S., Kiran, U., Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth 18:2 (2004), 141–143, 10.1053/j.jvca.2004.01.016.
26. Chauhan, S., Bisoi, A., Modi, R., Gharde, P., Rajesh, M.R., Tranexamic acid in paediatric cardiac surgery. Indian J Med Res 118 (2003), 86–89.
27. Pleym, H., Stenseth, R., Wahba, A., Bjella, L., Karevold, A., Dale, O., Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesth Analg 96:4 (2003), 923–928, 10.1213/01.ane.0000054001.37346.03.
28. Zabeeda, D., Medalion, B., Sverdlov, M., Ezra, S., Schachner, A., Ezri, T., et al. Tranexamic acid reduces bleeding and the need for blood transfusion in primary myocardial revascularization. Ann Thorac Surg 74:3 (2002), 733–738, 10.1016/s0003-4975(02)03784-0.
29. Fergusson, D.A., Hébert, P.C., Mazer, C.D., Fremes, S., MacAdams, C., Murkin, J.M., et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358 (2008), 2319–2331, 10.1056/NEJMoa0802395.
30. Ng, W., Jerath, A., Wąsowicz, M., Tranexamic acid: a clinical review. Anaesthesiol Intensive Ther 47:4 (2015), 339–350, 10.5603/AIT.a2015.0011.
31. De Vries, A.J., Lansink-Hartgring, A.O., Fernhout, F.J., Huet, R.C.G., van den Heuvel, E.R., The activated clotting time in cardiac surgery: should Celite or kaolin be used?. Interact Cardiovasc Thorac Surg 24:4 (2017), 549–554, 10.1093/icvts/ivw435.
32. Wang, J.S., Lin, C.Y., Hung, W.T., Karp, R.B., Monitoring of heparin-induced anticoagulation with kaolin activated clotting time in cardiac surgical patients treated with aprotinin. Anesthesiology 77 (1992), 1080–1084, 10.1097/00000542-199212000-00006.
33. Dietrich, W., Jochum, M., Effect of Celite and kaolin on activated clotting time in the presence of aprotinin: activated clotting time is reduced by binding of aprotinin to kaolin. J Thorac Cardiovasc Surg 109 (1995), 177–178, 10.1016/S0022-5223(95)70433-7.
34. Bechtel, J.F., Prosch, J., Sievers, H.H., Bartels, C., Is the kaolin or celite activated clotting time affected by tranexamic acid?. Ann Thorac Surg 74:2 (2002), 390–393, 10.1016/s0003-4975(02)03744-x.
35. Khan, N.U., Wayne, C.K., Barker, J., Strang, T., The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph. Eur J Anaesthesiol 27:7 (2010), 624–627, 10.1097/EJA.0b013e32833731bd.