Systematic review and meta-analyses of tranexamic acid use for bleeding reduction in prostate surgery

Journal of Clinical Anesthesia

Volumn 48, Issue , 2018, Pages 32-38

  Longo, Marcelo A ^a   Cavalheiro, Bárbara T ^a   de Oliveira Filho, Getúlio R ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Anesthesia; Blood loss; Prostate; Review; Surgical; Systematic; Tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLOOD TRANSFUSION; CLINICAL OUTCOME; DEEP VEIN THROMBOSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; INCIDENCE; LUNG EMBOLISM; MALE; META ANALYSIS; OPERATIVE BLOOD LOSS; PRIORITY JOURNAL; PROSTATE SURGERY; PROSTATECTOMY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; EVALUATION STUDY; PROSTATE HYPERTROPHY; PROSTATE TUMOR; STATISTICS AND NUMERICAL DATA; THROMBOEMBOLISM;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; HUMANS; INCIDENCE; MALE; PROSTATECTOMY; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; THROMBOEMBOLISM; TRANEXAMIC ACID;

EID: 85046342816     PISSN: 09528180     EISSN: 18734529     Source Type: Journal    
DOI: 10.1016/j.jclinane.2018.04.014     Document Type: Review

References (49)

1. Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2017. CA Cancer J Clin 67 (2017), 7–30.
2. Bushman, W., Etiology, epidemiology, and natural history of benign prostatic hyperplasia. Urol Clin North Am 36 (2009), 403–415 [v].
3. Schraudenbach, P., Bermejo, C.E., Management of the complications of radical prostatectomy. Curr Urol Rep 8 (2007), 197–202.
4. Donohue, J.F., Sharma, H., Abraham, R., Natalwala, S., Thomas, D.R., Foster, M.C., Transurethral prostate resection and bleeding: a randomized, placebo controlled trial of role of finasteride for decreasing operative blood loss. J Urol 168 (2002), 2024–2026.
5. Gratzke, C., Schlenker, B., Seitz, M., Karl, A., Hermanek, P., Lack, N. et al., Complications and early postoperative outcome after open prostatectomy in patients with benign prostatic enlargement: results of a prospective multicenter study. J Urol 177 (2007), 1419–1422.
6. Nielsen, J.D., Gram, J., Holm-Nielsen, A., Fabrin, K., Jespersen, J., Post-operative blood loss after transurethral prostatectomy is dependent on in situ fibrinolysis. Br J Urol 80 (1997), 889–893.
7. Ziegler, S., Ortu, A., Reale, C., Proietti, R., Mondello, E., Tufano, R. et al., Fibrinolysis or hypercoagulation during radical prostatectomy? An evaluation of thrombelastographic parameters and standard laboratory tests. Eur J Anaesthesiol 25 (2008), 538–543.
8. Ficarra, V., Novara, G., Artibani, W., Cestari, A., Galfano, A., Graefen, M. et al., Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. Eur Urol 55 (2009), 1037–1063.
9. Wang, J.K., Klein, H.G., Red blood cell transfusion in the treatment and management of anaemia: the search for the elusive transfusion trigger. Vox Sang 98 (2010), 2–11.
10. Hendrickson, J.E., Hillyer, C.D., Noninfectious serious hazards of transfusion. Anesth Analg 108 (2009), 759–769.
11. Hebert, P.C., Wells, G., Tweeddale, M., Martin, C., Marshall, J., Pham, B. et al., Does transfusion practice affect mortality in critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group. Am J Respir Crit Care Med 155 (1997), 1618–1623.
12. Chun, T.Y., Martin, S., Lepor, H., Preoperative recombinant human erythropoietin injection versus preoperative autologous blood donation in patients undergoing radical retropubic prostatectomy. Urology 50 (1997), 727–732.
13. Terada, N., Arai, Y., Matsuta, Y., Maekawa, S., Okubo, K., Ogura, K. et al., Acute normovolemic hemodilution for radical prostatectomy: can it replace preoperative autologous blood transfusion?. Int J Urol 8 (2001), 149–152.
14. McCormack, P.L., Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 72 (2012), 585–617.
15. Ortmann, E., Besser, M.W., Klein, A.A., Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth 111 (2013), 549–563.
16. Mannucci, P.M., Hemostatic drugs. N Engl J Med 339 (1998), 245–253.
17. Henry, D.A., Carless, P.A., Moxey, A.J., O'Connell, D., Stokes, B.J., Fergusson, D.A. et al., Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev, 2011, CD001886.
18. Chen, S., Wu, K., Kong, G., Feng, W., Deng, Z., Wang, H., The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis. BMC Musculoskelet Disord, 17, 2016, 81.
19. Cheriyan, T., Maier, S.P. 2nd, Bianco, K., Slobodyanyuk, K., Rattenni, R.N., Lafage, V. et al., Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J 15 (2015), 752–761.
20. Ker, K., Prieto-Merino, D., Roberts, I., Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg 100 (2013), 1271–1279.
21. Topsoee, M.F., Bergholt, T., Ravn, P., Schouenborg, L., Moeller, C., Ottesen, B. et al., Anti-hemorrhagic effect of prophylactic tranexamic acid in benign hysterectomy-a double-blinded randomized placebo-controlled trial. Am J Obstet Gynecol 215 (2016), 72 e1–8.
22. Massicotte, L., Denault, A.Y., Beaulieu, D., Thibeault, L., Hevesi, Z., Roy, A., Aprotinin versus tranexamic acid during liver transplantation: impact on blood product requirements and survival. Transplantation 91 (2011), 1273–1278.
23. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Group P, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6, 2009, e1000097.
24. Higgins, J.P., Altman, D.G., Gotzsche, P.C., Juni, P., Moher, D., Oxman, A.D. et al., The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, 2011, d5928.
25. Wan, X., Wang, W., Liu, J., Tong, T., Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol, 14, 2014, 135.
26. Sterne, J.A., Sutton, A.J., Ioannidis, J.P., Terrin, N., Jones, D.R., Lau, J. et al., Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ, 343, 2011, d4002.
27. Egger, M., Davey Smith, G., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997), 629–634.
28. Balshem, H., Helfand, M., Schunemann, H.J., Oxman, A.D., Kunz, R., Brozek, J. et al., GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 64 (2011), 401–406.
29. Crescenti, A., Borghi, G., Bignami, E., Bertarelli, G., Landoni, G., Casiraghi, G.M. et al., Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial. BMJ, 343, 2011, d5701.
30. Hayashi, I., Yoshida, K., Miyamoto, Y., Ijyuin, M., Matsushima, S., Ikuma, S. et al., Clinical effect of tranexamic acid to control hemorrhage during and following prostatectomy in prostatic hypertrophy: a study with a double blind method. Acta Urologica Japonica 22 (1976), 793–807.
31. Jendoubi, A., Malouch, A., Bouzouita, A., Riahi, Y., Necib, H., Ghedira, S. et al., Safety and efficacy of intravenous tranexamic acid in endoscopic transurethral resections in urology: Prospective randomized trial. Prog Urol 27:16 (2017), 1036–1042.
32. Meng, Q.Q., Xiong, J.Y., Pan, N., Effect of tranexamic acid on perioperative blood loss during transurethral resection of prostate. J Dalian Med Univ 36 (2014), 575–579 [Chinese].
33. Miller, R.A., May, M.W., Hendry, W.F., Whitfield, H.N., Wickham, J.E., The prevention of secondary haemorrhage after prostatectomy: the value of antifibrinolytic therapy. Br J Urol 52 (1980), 26–28.
34. Mirmansouri, A., Farzi, F., Imantalab, V., Khoshrang, H., Biazar, G., Khanjanian, G. et al., A survey on the effects of intravenous tranexamic acid on the amount of transfusion in patients undergoing T.U.R.-P. J Guilan Univ Med Sci 25 (2016), 110–116 [Persian].
35. Pawar, P.R., Kansal, S.V., Chaudhary, M., Baldha, M., Makwana, N., Makwana, H., Comparative study of role of pre-operative injection tranexamic acid in 80 cases of transurethral resection of prostate. Int J Sci Study 4 (2016), 167–170.
36. Pourfakhr, P., Gatavi, E., Gooran, S., Etezadi, F., Khajavi, M.R., Pourroustaei, R. et al., Local administration of tranexamic acid during prostatectomy surgery: effects on reducing the amount of bleeding. Nephrourol Mon, 8, 2016, e40409.
37. Rannikko, A., Petas, A., Taari, K., Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy. Urology 64 (2004), 955–958.
38. Elliott, S.P., Sweet, R.M., Contemporary surgical management of benign prostatic hyperplasia: what do recent trends imply for urology training?. Curr Prostate Rep 7 (2009), 19–24.
39. Gupta, N.P., Anand, A., Lasers are superfluous for the surgical management of benign prostatic hyperplasia in the developing world. Indian J Urol 25 (2009), 413–414.
40. Wong, D.H., Hagar, J.M., Mootz, J., Christiano, M., Vora, S.H., Miller, J.B. et al., Incidence of perioperative myocardial ischemia in TURP patients. J Clin Anesth 8 (1996), 627–630.
41. Moul, J.W., Sun, L., Wu, H., McLeod, D.G., Amling, C., Lance, R. et al., Factors associated with blood loss during radical prostatectomy for localized prostate cancer in the prostate-specific antigen (PSA)-era: an overview of the Department of Defense (DOD) Center for Prostate Disease Research (CPDR) national database. Urol Oncol 21 (2003), 447–455.
42. Karl, A., Buchner, A., Becker, H., Staehler, M., Seitz, M., Stief, C., Perioperative blood loss in open retropubic radical prostatectomy - is it safe to get operated at an educational hospital?. Eur J Med Res 14 (2009), 292–296.
43. Lopez-Picado, A., Albinarrate, A., Barrachina, B., Determination of perioperative blood loss: accuracy or approximation?. Anesth Analg 125 (2017), 280–286.
44. Rothermel, L.D., Lipman, J.M., Estimation of blood loss is inaccurate and unreliable. Surgery 160 (2016), 946–953.
45. Rassweiler, J., Teber, D., Kuntz, R., Hofmann, R., Complications of transurethral resection of the prostate (TURP)—incidence, management, and prevention. Eur Urol 50 (2006), 969–979 [discussion 80].
46. Chin, J.L., Srigley, J., Mayhew, L.A., Rumble, R.B., Crossley, C., Hunter, A. et al., Guideline for optimization of surgical and pathological quality performance for radical prostatectomy in prostate cancer management: evidentiary base. Can Urol Assoc J 4 (2010), 13–25.
47. Ungjaroenwathana, W., Bunyaratavej, C., Tosukhowong, P., Dissayabutra, T., Estimation of blood loss in transurethral resection of prostate (TUR-P) by urine-strip. J Med Assoc Thai 90 (2007), 2409–2415.
48. Rice, K.R., Brassell, S.A., McLeod, D.G., Venous thromboembolism in urologic surgery: prophylaxis, diagnosis, and treatment. Rev Urol 12 (2010), e111–24.
49. Beyer, J., Wessela, S., Hakenberg, O.W., Kuhlisch, E., Halbritter, K., Froehner, M. et al., Incidence, risk profile and morphological pattern of venous thromboembolism after prostate cancer surgery. J Thromb Haemost 7 (2009), 597–604.