Efficacy and Safety of Tranexamic Acid for Blood Salvage in Intertrochanteric Fracture Surgery: A Meta-Analysis

Clinical and Applied Thrombosis/Hemostasis

Volumn 24, Issue 8, 2018, Pages 1189-1198

  Zhu, Qianzheng ^a   Yu, Caixia ^a   Chen, Xingzuo ^a   Xu, Xiaodong ^a   Chen, Ying ^a   Liu, Chenggang ^a   Lin, Peng ^a  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

intertrochanteric fracture; meta analysis; randomized controlled trial; surgery; tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID;

BIBLIOGRAPHIC DATABASE; BLEEDING; BLOOD SALVAGE; BLOOD TRANSFUSION; COCHRANE LIBRARY; DATA EXTRACTION; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; HEMATOCRIT; HUMAN; LUNG EMBOLISM; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; THROMBOEMBOLISM; HIP FRACTURE; POSTOPERATIVE COMPLICATION; PROCEDURES;

HIP FRACTURES; HUMANS; OPERATIVE BLOOD SALVAGE; POSTOPERATIVE COMPLICATIONS; THROMBOEMBOLISM; TRANEXAMIC ACID;

EID: 85049014632     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029618783258     Document Type: Review

References (34)

1. Davidson CW, Merrilees MJ, Wilkinson TJ, McKie JS, Gilchrist NL. Hip fracture mortality and morbidity—can we do better? N Z Med J. 2001;114(1136):329–332
2. Vijay BS, Bedi V, Mitra S, Das B. Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries. Saudi J Anaesth. 2013;7(1):29–32
3. Foss NB, Kehlet H. Hidden blood loss after surgery for hip fracture. J Bone Joint Surg Br. 2006;88(8):1053–1059
4. Haentjens P, Magaziner J, Colon-Emeric CS. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med. 2010;152(6):380–390
5. Bhaskar D, Parker MJ. Haematological indices as surrogate markers of factors affecting mortality after hip fracture. Injury. 2011;42(2):178–182
6. Chen Y, Chen Z, Cui S, Li Z, Yuan Z. Topical versus systemic tranexamic acid after total knee and hip arthroplasty: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2016;95(41):e4656
7. Moher D, Liberati A, Tetzlaff J, Altman DG,; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–1012
8. Higgins JPT, Green S, (eds). Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration. 2011. Available from http://www.cochrane-handbook.org. Updated March 2011
9. Atkins D, Best D, Briss PA,; GRADE Working Group. Grading quality of evidence and strength of recommendations. BMJ. 2004;328(7454):1490
10. Baruah RK, Borah PJ, Haque R. Use of tranexamic acid in dynamic hip screw plate fixation for trochanteric fractures. J Orthop Surg (Hong Kong). 2016;24(3):379–382
11. Drakos A, Raoulis V, Karatzios K. Efficacy of local administration of tranexamic acid for blood salvage in patients undergoing intertrochanteric fracture surgery. J Orthop Trauma. 2016;30(8):409–414
12. Lei J, Zhang B, Cong Y. Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial. J Orthop Surg Res. 2017;12(1):124
13. Mohib Y, Rashid RH, Ali M, Zubairi AJ, Umer M. Does tranexamic acid reduce blood transfusion following surgery for inter-trochanteric fracture? A randomized control trial. J Pak Med Assoc. 2015;65(11 suppl 3):S17–S20
14. Tengberg PT, Foss NB, Palm H, Kallemose T, Troelsen A. Tranexamic acid reduces blood loss in patients with extracapsular fractures of the hip: results of a randomised controlled trial. Bone Joint J. 2016;98-B(6):747–753
15. Tian S, Shen Z, Liu Y, Zhang Y, Peng A. The effect of tranexamic acid on hidden bleeding in older intertrochanteric fracture patients treated with PFNA. Injury. 2018;49(3):680–684
16. Virani SR, Dahapute AA, Panda I, Bava SS. Role of local infiltration of tranexamic acid in reducing blood loss in peritrochanteric fracture surgery in the elderly population. Malays Orthop J. 2016;10(3):26–30
17. Dillon MF, Collins D, Rice J. Preoperative characteristics identify patients with hip fractures at risk of transfusion. Clin Orthop Relat Res. 2005;439:201–206
18. Smith GH, Tsang J, Molyneux SG, White TO. The hidden blood loss after hip fracture. Injury. 2011;42(2):133–135
19. Watts CD, Houdek MT, Sems SA, Cross WW, Pagnano MW. Tranexamic acid safely reduced blood loss in hemi- and total hip arthroplasty for acute femoral neck fracture: a randomized clinical trial. J Orthop Trauma. 2017;31(7):345–351
20. Gao F, Sun W, Guo W, Li Z, Wang W, Cheng L. Topical administration of tranexamic acid plus diluted-epinephrine in primary total knee arthroplasty: a randomized double-blinded controlled trial. J Arthroplasty. 2015;30(8):1354–1358
21. Peng ZM, Jifeng LM, Xiao WM. Combined versus single application of tranexamic acid in total knee and hip arthroplasty: a meta-analysis of randomized controlled trials. Int J Surg. 2017;43:171–180
22. Shokoohi A, Stanworth S, Mistry D, Lamb S, Staves J, Murphy MF. The risks of red cell transfusion for hip fracture surgery in the elderly. Vox Sang. 2012;103(3):223–230
23. Engoren M, Mitchell E, Perring P, Sferra J. The effect of erythrocyte blood transfusions on survival after surgery for hip fracture. J Trauma. 2008;65(6):1411–1415
24. Zhang P, He J, Fang Y, Chen P, Liang Y, Wang J. Efficacy and safety of intravenous tranexamic acid administration in patients undergoing hip fracture surgery for hemostasis: a meta-analysis. Medicine (Baltimore). 2017;96(21):e6940
25. Farrow LS, Smith TO, Ashcroft GP, Myint PK. A systematic review of tranexamic acid in hip fracture surgery. Br J Clin Pharmacol. 2016;82(6):1458–1470
26. Wang W, Yu J. Tranexamic acid reduces blood loss in intertrochanteric fractures. Medicine(Baltimore). 2017;96(52):e9396
27. Pilbrant A, Schannong M, Vessman J. Pharmacokinetics and bioavailability of tranexamic acid. Eur J Clin Pharmacol. 1981;20(1):65–72
28. Puigdellivol E, Carral ME, Moreno J, Plà-Delfina JM, Jané F. Pharmacokinetics and absolute bioavailability of intramuscular tranexamic acid in man. Int J Clin Pharmacol Ther Toxicol. 1985;23(6):298–301
29. Benoni G, Lethagen S, Fredin H. The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty. Thromb Res. 1997;85(3):195–206
30. Astedt B, Liedholm P, Wingerup L. The effect of tranexamic acid on the fibrinolytic activity of vein walls. Ann Chir Gynaecol. 1978;67(6):203–205
31. Gausden EB, Qudsi R, Boone MD. Tranexamic acid in orthopaedic trauma surgery. J Orthopaedic Trauma. 2018;31(10):1
32. Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J. 2014;96-B(8):1005–1015
33. Li ZJ, Fu X, Xing D. Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J. 2013;22(9):1950–1957
34. Sun X, Dong Q, Zhang YG. Intravenous versus topical tranexamic acid in primary total hip replacement: a systemic review and meta-analysis. Int J Surg. 2016;32:10–18