Effect of multispecies probiotic on gut microbiota composition in individuals with intestinal constipation: A double-blind, placebo-controlled randomized trial

Nutrition

Volumn 78, Issue , 2020, Pages

  Botelho, Patrícia Borges ^a   Ferreira, Marcus Vinícius Rodrigues ^a   Araújo, Ananda de Mesquita ^a   Mendes, Marcela Moraes ^a   Nakano, Eduardo Yoshio ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Constipation; Microbiota; Probiotics

Indexed keywords

LAXATIVE; PROBIOTIC AGENT; RNA 16S;

ADULT; ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTEROIDETES; BIFIDOBACTERIUM BIFIDUM; BLAUTIA; BLAUTIA FAECIS; CALORIC INTAKE; CONSTIPATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; FECES MICROFLORA; FEMALE; FIRMICUTES; FOOD INTAKE; GENE SEQUENCE; HUMAN; INTESTINE FLORA; LACTOCOCCUS LACTIS; LIQUID FECES; MACRONUTRIENT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OUTCOME ASSESSMENT; PHYLOGENETIC TREE; PHYLUM; PHYSICAL ACTIVITY; POPULATION ABUNDANCE; PREVALENCE; PRIORITY JOURNAL; PROTEOBACTERIA; RANDOMIZED CONTROLLED TRIAL; RUMINOCOCCUS; RUMINOCOCCUS TORQUES; SPECIES COMPOSITION; SPECIES RICHNESS; TREATMENT OUTCOME; CLOSTRIDIALES;

CLOSTRIDIALES; CONSTIPATION; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; PROBIOTICS;

EID: 85089375997     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2020.110890     Document Type: Article

References (45)

1. Lee, K.N., Lee, O.Y., Intestinal microbiota in pathophysiology and management of irritable bowel syndrome. World J Gastroenterol 20 (2014), 8886–8897.
2. Zhao, Y., Yu, Y., Intestinal microbiota and chronic constipation. Springerplus, 5, 2016, 1130.
3. Hill, C., Guarner, F., Reid, G., Gibson, G.R., Mirenstein, D.J., Pot, B., et al. Expert consensus document. The international scientific association for probiotic and prebiotic consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepathol 11 (2014), 506–514.
4. Kommers, M.J., Silva Rodrigues, R.A., Miyajima F avala Zavala, A.A., Ultramari, V.R.L.M., Fett, W.C.R., et al. Effects of probiotic use on quality of life and physical activity in constipated female university students: a randomized, double-blind placebo. J Altern Complement Med 25 (2019), 1163–1171.
5. Dimidi, E., Christodoulides, S., Fragkos, K.C., Scott, S.M., Whelan, K., The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 100 (2014), 1075–1084.
6. Wang, L., Hu, L., Xu, Q., Yin, B., Fang, D., Wang, G., et al. Bifidobacterium adolescentis exerts strain-specific effects on constipation induced by loperamide in BALB/c mice. Int J Mol Sci, 18, 2017, E318.
7. Nieuwboer, V.D.M., Klomp-Hogeterp, A., Verdoorn, S., Metsemakers-Brameijer, L., Vriend, T.M., Claassen, E., et al. Improving the bowel habit of elderly residents in a nursing home using probiotic fermented milk drink. Benef Microbes 6 (2015), 397–403.
8. Wilms, E., Gerritsen, J., Smidt, H., Besseling-van der Vaart, I., Rijkers, G.T., Garcia Fuentes, A.R., et al. Effects of supplementation of the Synbiotic Ecologic® 825/FOS P6 on intestinal barrier function in healthy humans: a randomized controlled trial. PLos One, 11, 2016, e0167775.
9. Cudmore, S., Doolan, A., Lacey, S., Shanahan, F.A., randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation. Int J Food Sci Nutr 8 (2017), 366–377.
10. Yeun, Y., Lee, J., Effect of a double-coated probiotic formulation on functional constipation in the elderly: a randomized, double blind, controlled study. Arch Pharm Res 38 (2015), 1345–1350.
11. Macfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., Macfarlane, G.T., Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study. Aliment Pharmacol Ther 38 (2013), 804–816.
12. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., Lipman, D.J., Basic local alignment search tool. J Mol Biol 215 (1990), 403–410.
13. Christoff, A.P., Cruz, G.N.F., Sereia, A.F.R., Yamanaka, L.E., Silveira, P.P., de Oliveira, L.F.V., End-to-end assessment of fecal bacteriome analysis: from sample processing to DNA sequencing and bioinformatics results. BioRxiv, 22, 2019.
14. R Development Core Team. R. a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
15. Sievers, F., Wilm, A., Dineen, D., Gibson, T.J., Karplus, K., Li, W., et al. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol, 7, 2011, 539.
16. Price, M.N., Dehal, P.S., Arkin, A.P., FastTree: computing large minimum-evolution trees with profiles instead of a distance matrix. Mol Biol Evol 26 (2009), 1641–1650.
17. Felsenstein, J., PHYLIP (Phylogeny Inference Package) version 3.6. Distributed by the author. 2005, Department of Genome Sciences, University of Washington, Seattle.
18. McMurdie, P.J., Holmes, S., Phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data. PLos One, 8, 2013, e61217.
19. Love, M.I., Huber, W., Anders, S., Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol, 15, 2014, 550.
20. Ferrario, C., Taverniti, V., Milani, C., Fiore, W., Laureati, M., De Noni, I., et al. Modulation of fecal Clostridiales bacteria and butyrate by probiotic intervention with Lactobacillus paracasei DG varies among healthy adults. J Nutr 144 (2014), 1787–1796.
21. Zhu, L., Liu, W., Alkhouri, R., Baker, R.D., Bard, J.E., Quigley, E.M., et al. Structural changes in the gut microbiome of constipated patients. Physiol Genomics 46 (2014), 679–686.
22. Malinen, E., Krogius-Kurikka, L., Lyra, A., Nikkilä, J., Jääskeläinen, A., Rinttilä, T., et al. Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome. World J Gastroenterol 28 (2010), 4532–4540.
23. Zeng, M.Y., Inohara, N., Nuñez, G., Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunol 10 (2017), 18–26.
24. Castro-Combs, J., Garcia, C.J., Majewski, M., Wallner, G., Sarosiek, J., Impaired viscosity of gastric secretion and its mucin content as potential contributing factors to the development of chronic constipation. Dig Dis Sci 59 (2014), 2730–2734.
25. Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., et al. Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am J Gastroenterol 100 (2005), 373–382.
26. Parkes, G.C., Rayment, N.B., Hudspith, B.N., Petrovska, L., Lomer, M.C., Brostoff, J., et al. Distinct microbial populations exist in the mucosa-associated microbiota of sub-groups of irritable bowel syndrome. Neurogastroenterol Motil 24 (2012), 31–39.
27. Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L.P., Lochs, H., Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol 43 (2005), 3380–3389.
28. Rajilic-Stojanovi, M., Biagi, E., Heilig, H.G., Kajander, K., Kekkonen, R.A., Tims, S., et al. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141 (2011), 1792–1801.
29. Lyra, A., Rinttila, T., Nikkila, J., Krogius-Kurikka, L., Kajander, K., Malinen, E., et al. Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification. World J Gastroenterol 15 (2009), 5936–5945.
30. Yu, T., Zheng, Y.P., Tan, J.C., Xiong, W.J., Wang, Y., Lin, L., Effects of prebiotics and synbiotics on functional constipation. Am J Med Sci 353 (2017), 282–292.
31. Mezzasalma, V., Manfrini, E., Ferri, E., Sandionigi, A., La Ferla, B., Schiano, I., et al. A randomized, double-blind, placebo-controlled trial: the efficacy of multispecies probiotic supplementation in alleviating symptoms of irritable bowel syndrome associated with constipation. BioMed Res Int, 2016, 2016, 4740907.
32. Miller, L.E., Zimmermann, A.K., Ouwehand, A.C., Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit. World J Gastroenterol, 22, 2016, 5122.
33. Khalif, I.L., Quigley, E.M., Konovitch, E.A., Maximova, I.D., Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation. Dig Liver Dis 37 (2005), 838–849.
34. Dimidi, E., Christodoulides, S., Scott, S.M., Whelan, K., Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Adv in Nutr 8 (2017), 484–494.
35. Corr, S.C., Hill, C., Gahan, C.G., Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens. Adv Food Nutr Res 56 (2009), 1–15.
36. Guo, S., Liu, D., Zhang, B., Li, Z., Li, Y., Ding, B., et al. Two Lactobacillus species inhibit the growth and α-toxin production of Clostridium perfringens and induced proinflammatory factors in chicken intestinal epithelial cells in vitro. Front Microbiol, 8, 2017, 2081.
37. Coconnier, M.H., Liévin, V., Bernet-Camard, M.F., Hudault, S., Servin, A.L., Antibacterial effect of the adhering human Lactobacillus acidophilus strain LB. Antimicrob Agents Chemother 41 (1997), 1046–1052.
38. Pascual, L.M., Daniele, M.B., Giordano, W., Pájaro, M.C., Barberis, I.L., Purification and partial characterization of novel bacteriocin L23 produced by Lactobacillus fermentum L23. Curr Microbiol 56 (2008), 397–402.
39. Mazlyn, M.M., Nagarajah, L.H., Fatimah, A., Norimah, A.K., Goh, K.L., Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study. J Gastroenterol Hepatol 28 (2013), 1141–1147.
40. Moreira, T.R., Leonhardt, D., Conde, S.R., Influence of drinking a probiotic fermented milk beverage containing Bifidobacterium animalis on the symptoms of constipation. Arq Gastroenterol 54 (2017), 206–210.
41. Eskesen, D., Jespersen, L., Michelsen, B., Whorwell, P.J., Müller-Lissner, S., Morberg, C.M., Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr 114 (2015), 1638–1646.
42. Miller, L.E., Ouwehand, A.C., Ibarra, A., Effects of probiotic-containing products on stool frequency and intestinal in constipated adults: systematic review and meta-analysis of randomized controlled trials. Ann Gastroenterol 30 (2017), 629–639.
43. Ballou, S., Beath, A., Kaptchuk, T.J., Hirsch, W., Sommers, T., Nee, J., et al. Factors associated with response to placebo in patients with irritable bowel syndrome and constipation. Clin Gastroenterol Hepatol 16 (2018), 1738–1744.
44. Dorn, S.D., Kaptchuk, T.J., Park, J.B., Nguyen, L.T., Canenguez, K., Nam, B.H., et al. A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. Neurogastroenterol Motil 19 (2007), 630–637.
45. Ford, A.C., Moayyedi, P., Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome. Aliment Pharmacol Ther 32 (2010), 144–158.