A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation

International Journal of Food Sciences and Nutrition

Volumn 68, Issue 3, 2017, Pages 366-377

  Cudmore, Sally ^a,b   Doolan, Andrea ^a   Lacey, Seán ^c   Shanahan, Fergus ^a,b,d  

^a Atlantia Food Clinical Trials   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c Department of Chemistry   (Ireland)

^d Department of Medicine National University of Ireland Cork   (Ireland)

Author keywords

clinical trial; Constipation; fibre; Lepicol; probiotic; symbiotic

Indexed keywords

INULIN; PROBIOTIC AGENT; SYNBIOTIC AGENT;

ADMINISTRATION AND DOSAGE; ADULT; CHRONIC DISEASE; CONSTIPATION; CONTROLLED STUDY; DEFECATION; DIETARY FIBER; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; PHYSIOLOGY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; CHRONIC DISEASE; CONSTIPATION; DEFECATION; DIETARY FIBER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INULIN; MALE; MIDDLE AGED; PROBIOTICS; QUALITY OF LIFE; SYNBIOTICS; TREATMENT OUTCOME;

EID: 84992316963     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.1080/09637486.2016.1244661     Document Type: Article

References (26)

1. Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ., 2007. Cumulative incidence of chronic constipation:a population-based study 1988–2003. Aliment Pharmacol Ther. 26:1521–1528.
2. Crowell M, Harries LA, Lunsford TN, Dibiase JK., 2009. Emerging drugs for chronic constipation. Expert Opin Emerg Drugs. 14:493–504.
3. Dik VK, Siersema PD, Joseph A, Hodgkins P, Smeets HM, van Oijen MG., 2014. Constipation-related direct medical costs in 16887 patients newly diagnosed with chronic constipation. Eur J Gastroenterol Hepatol. 26:1260–1266.
4. Fateh R, Iravani S, Frootan M, Rasouli MR, Saadat S., 2011. Synbiotic preparation in men suffering from functional constipation:a randomised controlled trial. Swiss Med Wkly. 141:w13239.
5. Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, et al. 2014. American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 109(Suppl 1):S2–S26.
6. Frank L, Kleinman L, Farup C, Taylor L, Miner P, Jr.1999. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. 34:870–877.
7. Gibson GR, Roberfroid MB., 1995. Dietary modulation of the human colonic microbiota:introducing the concept of prebiotics. J Nutr. 125:1401–1412.
8. Gudsoorkar VS1, Quigley EM., 2013. Emerging treatments for chronic constipation. Expert Opin Emerg Drugs. 18:365–373.
9. Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FE, Hughes AO., 1992. Defecation frequency and timing, and stool form in the general population:a prospective study. Gut. 33:818–824.
10. Hunt R, Dhaliwal S, Tougas G, Pedro C, Labbé JF, Paul H, Ennamorato M., 2007. Prevalence, impact and attitudes toward lower gastrointestinal dysmotility and sensory symptoms, and their treatment in Canada:a descriptive study. Can J Gastroenterol. 21:31–37.
11. Irvine EJ, Ferrazzi S, Pare P, Thompson WG, Rance L., 2002. Health-related quality of life in functional GI disorders:Focus on constipation and resource utilization. Am J Gastroenterol. 97:1986–1993.
12. Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O., 2005. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol. 40:540–551.
13. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B., 2011. Effects of chicory inulin in constipated elderly people:a double-blind controlled trial. Int J Food Sci Nutr. 62:164–170.
14. McRorie J, Daggy B, Morel J, Diersing P, Miner P, Robinson M., 1998. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther. 12:491–497.
15. Musial F, Klosterhalfen S, Enck P., 2007. Placebo responses in patients with gastrointestinal disorders. World J Gastroenterol. 13:3425–3429.
16. Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L., 2001. An epidemiological survey of constipation in Canada:definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol. 96:3130–3137.
17. Petschow B, Doré J, Hibberd P, Dinan T, Reid G, Blaser M, Cani PD, Degnan FH, et al. 2013. Probiotics, prebiotics, and the host microbiome:the science of translation. Ann NY Acad Sci. 1306:1–17.
18. Phatak UP, Pashankar DS., 2014. Prevalence of functional gastrointestinal disorders in obese and overweight children. Int J Obes (Lond). 38:1324–1327.
19. Pinto Sanchez MI, Bercik P., 2011. Epidemiology and burden of chronic constipation. Can J Gastroenterol. 25(Suppl B):11B–15B.
20. Quigley EM., 2012. Probiotics in the management of functional bowel disorders:promise fulfilled? Gastroenterol Clin North Am. 41:805–819.
21. Quigley EM., 2011. The enteric microbiota in the pathogenesis and management of constipation. Best Pract Res Clin Gastroenterol. 25:119–126.
22. Roerig JL, Steffen KJ, Mitchell JE, Zunker C., 2010. Laxative abuse:epidemiology, diagnosis and management. Drugs. 70:1487–1503.
23. Suares NC, Ford AC., 2011. Systematic review:the effects of fibre in the management of chronic idiopathic constipation. Aliment Pharmacol Ther. 33:895–901.
24. Talley NJ, Fleming KC, Evans JM, O'keefe EA, Weaver AL, Zinsmeister AR, Melton LJ, 3rd. 1996. Constipation in an elderly community:a study of prevalence and potential risk factors. Am J Gastroenterol. 91:19–25.
25. Talley NJ, Weaver AL, Zinsmeister AR, Melton LJ., 3rd. 1993. Functional constipation and outlet delay:a population-based study. Gastroenterology. 105:781–790.
26. Tejero-Sarinena S, Barlow J, Costabile A, Gibson GR, Rowland I., 2012. In vitro evaluation of the antimicrobial activity of a range of probiotics against pathogens:evidence for the effects of organic acids. Anaerobe. 18:530–538.