A suspicious role of interferon in the pathogenesis of SARS-CoV-2 by enhancing expression of ACE2

Signal Transduction and Targeted Therapy

Volumn 5, Issue 1, 2020, Pages

  Su, Shan ^a   Jiang, Shibo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; INTERFERON; DIPEPTIDYL CARBOXYPEPTIDASE;

CORONAVIRUS DISEASE 2019; HUMAN; IMMUNE RESPONSE; LUNG ALVEOLUS CELL; NONHUMAN; NOTE; PROTEIN EXPRESSION; RNA EXTRACTION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS ENTRY; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION; BETACORONAVIRUS; CORONAVIRUS INFECTION; GENE EXPRESSION REGULATION; GENETICS; PANDEMIC; PATHOGENICITY; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; VIROLOGY; VIRUS PNEUMONIA;

BETACORONAVIRUS; CORONAVIRUS INFECTIONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERONS; PANDEMICS; PEPTIDYL-DIPEPTIDASE A; PNEUMONIA, VIRAL; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS;

EID: 85085195735     PISSN: 20959907     EISSN: 20593635     Source Type: Journal    
DOI: 10.1038/s41392-020-0185-z     Document Type: Note

References (5)

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4. Chu, H. et al. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin. Infect. Dis. 10.1093/cid/ciaa410 (2020).
5. Haagmans, B. L. et al. Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat. Med. 10, 290–293 (2004).