Efficacy of quadruple treatment on different types of pre-operative anaemia: secondary analysis of a randomised controlled trial

Anaesthesia

Volumn 75, Issue 8, 2020, Pages 1039-1049

  Rossler J ^a   Hegemann, I ^b   Schoenrath, F ^c   Seifert, B ^d   Kaserer, A ^a   Spahn, G H ^a   Falk, V ^c,e,f   Spahn, D R ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f ETH ZURICH   (Switzerland)

Author keywords

anaemia; deficiency; erythropoietin; iron; reticulocyte

Indexed keywords

ACIDUM FOLICUM; CYANOCOBALAMIN; ERYTHROPOIETIN; FERRIC CARBOXYMALTOSE; FERRITIN; FOLIC ACID; RECOMBINANT ERYTHROPOIETIN; TRANSCOBALAMIN; TRANSFERRIN; ANTIANEMIC AGENT; EPO PROTEIN, HUMAN; IRON; VITAMIN B COMPLEX;

AGED; ANEMIA; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ERYTHROCYTE; FEMALE; HUMAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; POST HOC ANALYSIS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETICULOCYTE COUNT; SECONDARY ANALYSIS; BLOOD TRANSFUSION; COMBINATION DRUG THERAPY; DOUBLE BLIND PROCEDURE; HEART SURGERY; INTRAVENOUS DRUG ADMINISTRATION; IRON DEFICIENCY ANEMIA; MIDDLE AGED; PREOPERATIVE CARE; PROCEDURES; VERY ELDERLY;

ADMINISTRATION, INTRAVENOUS; AGED; AGED, 80 AND OVER; ANEMIA; ANEMIA, IRON-DEFICIENCY; BLOOD TRANSFUSION; CARDIAC SURGICAL PROCEDURES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ERYTHROPOIETIN; FEMALE; FOLIC ACID; HEMATINICS; HUMANS; IRON; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; RETICULOCYTE COUNT; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 85084156849     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/anae.15062     Document Type: Article

References (31)

1. Munoz M, Laso-Morales MJ, Gomez-Ramirez S, Cadellas M, Nunez-Matas MJ, Garcia-Erce JA. Pre-operative haemoglobin levels and iron status in a large multicentre cohort of patients undergoing major elective surgery. Anaesthesia 2017; 72: 826–34.
2. Klein AA, Collier TJ, Brar MS, et al. The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit. Anaesthesia 2016; 71: 627–35.
3. Sanders J, Cooper JA, Farrar D, et al. Pre-operative anaemia is associated with total morbidity burden on days 3 and 5 after cardiac surgery: a cohort study. Perioperative Medicine 2017; 6: 1.
4. Padmanabhan H, Siau K, Curtis J, et al. Preoperative anemia and outcomes in cardiovascular surgery: systematic review and meta-analysis. Annals of Thoracic Surgery 2019; 108: 1840–8.
5. Ranucci M, Baryshnikova E, Castelvecchio S, Pelissero G, Surgical, Clinical Outcome Research G. Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Annals of Thoracic Surgery 2013; 96: 478–85.
6. LaPar DJ, Hawkins RB, McMurry TL, et al. Preoperative anemia versus blood transfusion: which is the culprit for worse outcomes in cardiac surgery? Journal of Thoracic and Cardiovascular Surgery 2018; 156: e2.
7. Mueller MM, Van Remoortel H, Meybohm P, et al. Patient blood management: recommendations from the 2018 frankfurt consensus conference. Journal of the American Medical Association 2019; 321: 983–97.
8. Dhir A, Tempe DK. Anemia and patient blood management in cardiac surgery-literature review and current evidence. Journal of Cardiothoracic and Vascular Anesthesia 2018; 32: 2726–42.
9. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public Health Nutrition 2009; 12: 444–54.
10. Kassebaum NJ, Collaborators GBDA. The global burden of anemia. Hematology/Oncology Clinics of North America 2016; 30: 247–308.
11. Camaschella C. Iron-deficiency anemia. New England Journal of Medicine 2015; 372: 1832–43.
12. Cappellini MD, Comin-Colet J, de Francisco A, et al. Iron deficiency across chronic inflammatory conditions: international expert opinion on definition, diagnosis, and management. American Journal of Hematology 2017; 92: 1068–78.
13. Rössler J, Schoenrath F, Seifert B, et al. Iron deficiency is associated with higher mortality in patients undergoing cardiac surgery: a prospective study. British Journal of Anaesthesia 2020; 124: 25–34.
14. Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood 2019; 133: 40–50.
15. Ganz T. Anemia of Inflammation. New England Journal of Medicine 2019; 381: 1148–57.
16. ® following a single subcutaneous administration in healthy male volunteers. Drug Design, Development and Therapy 2017; 11: 3127–35.
17. Goodnough LT, Monk TG, Andriole GL. Erythropoietin therapy. New England Journal of Medicine 1997; 336: 933–8.
18. Spahn DR, Schoenrath F, Spahn GH, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet 2019; 393: 2201–12.
19. Piva E, Brugnara C, Spolaore F, Plebani M. Clinical utility of reticulocyte parameters. Clinics in Laboratory Medicine 2015; 35: 133–63.
20. Mercadal L, Metzger M, Casadevall N, et al. Timing and determinants of erythropoietin deficiency in chronic kidney disease. Clinical Journal of the American Society of Nephrology 2012; 7: 35–42.
21. Munoz M, Acheson AG, Auerbach M, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia 2017; 72: 233–47.
22. McClellan W, Aronoff SL, Bolton WK, et al. The prevalence of anemia in patients with chronic kidney disease. Current Medical Research and Opinion 2004; 20: 1501–10.
23. Pfeffer MA, Burdmann EA, Chen CY, et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. New England Journal of Medicine 2009; 361: 2019–32.
24. Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. New England Journal of Medicine 2006; 355: 2085–98.
25. Risch M, Meier DW, Sakem B, et al. Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits. BMC Geriatrics 2015; 15: 82.
26. Field MS, Stover PJ. Safety of folic acid. Annals of the New York Academy of Sciences 2018; 1414: 59–71.
27. Zyuzkov GN, Abramova EV, Dygai AM, Goldberg ED. Reactions of the erythroid hemopoietic stem and their mechanisms during blood loss. Bulletin of Experimental Biology and Medicine 2005; 139: 27–31.
28. Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood 2000; 96: 823–33.
29. Jelkmann W. Regulation of erythropoietin production. Journal of Physiology 2011; 589: 1251–8.
30. Mesgarpour B, Heidinger BH, Roth D, Schmitz S, Walsh CD, Herkner H. Harms of off-label erythropoiesis-stimulating agents for critically ill people. Cochrane Database of Systematic Reviews 2017; 8: CD010969.
31. Sowade O, Ziemer S, Sowade B, et al. The effect of preoperative recombinant human erythropoietin therapy on platelets and hemostasis in patients undergoing cardiac surgery. Journal of Laboratory and Clinical Medicine 1997; 129: 376–83.