Timing and determinants of erythropoietin deficiency in chronic kidney disease

Clinical Journal of the American Society of Nephrology

Volumn 7, Issue 1, 2012, Pages 35-42

  Mercadal, Lucile ^a,b   Metzger, Marie ^a,b   Casadevall, Nicole ^c,d   Haymann, Jean Philippe ^e   Karras, Alexandre ^f   Boffa, Jean Jacques ^e,g   Flamant, Martin ^g,h   Vrtovsnik, Francois ^g,i   Stengel, Benedicte ^a,b   Froissart, Marc ^a,f  

^a CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d Universite Paris Sud   (France)

^e HÔPITAL TENON   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^g INSERM   (France)

^h SORBONNE UNIVERSITÉ   (France)

ⁱ BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHROMIUM 51; EDETIC ACID; ERYTHROPOIETIN; HEMOGLOBIN;

ADULT; AGED; ANEMIA; ARTICLE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; FEMALE; GLOMERULUS FILTRATION RATE; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; KIDNEY CLEARANCE; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; OBESITY;

ADULT; AGED; CHRONIC DISEASE; ERYTHROPOIETIN; FEMALE; GLOMERULAR FILTRATION RATE; HEMOGLOBINS; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; TIME FACTORS;

EID: 84857074209     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.04690511     Document Type: Article

References (42)

1. Goldwasser E, Kung CKH: Purification of erythropoietin. Proc Natl Acad Sci USA 68: 697-698, 1971
2. Shoemaker CB, Mitsock LD: Murine erythropoietin gene: Cloning, expression, and human gene homology. Mol Cell Biol 6: 849-858, 1986
3. Drüeke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355: 2071-2084, 2006
4. Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355: 2085-2098, 2006
5. Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R TREAT Investigators: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361: 2019-2032, 2009
6. Fishbane S, Miyawaki N, Szczech LA: Hypothesis: An erythro-poietin honeymoon phase exists. Kidney Int 78: 646-649, 2010
7. Erslev AJ: Erythropoietin. N Engl J Med 324: 1339-1344, 1991
8. Beguin Y, Clemons GK, Pootrakul P, Fillet G: Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood 81: 1067-1076, 1993
9. Fehr T, Ammann P, Garzoni D, Korte W, Fierz W, Rickli H, Wüthrich RP: Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia. Kidney Int 66: 1206-1211, 2004
10. Walle AJ, Wong GY, Clemons GK, Garcia JF, Niedermayer W: Erythropoietin-hematocrit feedback circuit in the anemia of end-stage renal disease. Kidney Int 31: 1205-1209, 1987
11. Ross RP, McCrea JB, Besarab A: Erythropoietin response to blood loss in hemodialysis patients in blunted but preserved. ASAIO J 40: M880-M885, 1994
12. Brookhart MA, Schneeweiss S, Avorn J, Bradbury BD, Rothman KJ, Fischer M, Mehta J, Winkelmayer WC: The effect of altitude on dosing and response to erythropoietin in ESRD. J Am Soc Nephrol 19: 1389-1395, 2008
13. McGonigle RJ, Wallin JD, Shadduck RK, Fisher JW: Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. Kidney Int 25: 437-444, 1984
14. Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM: Serum erythropoietin concentration in chronic renal failure: Relationship to degree of anemia and excretory renal function. Blood 54: 877-884, 1979
15. Moranne O, Froissart M, Rossert J, Gauci C, Boffa JJ, Haymann JP, M'rad MB, Jacquot C, Houillier P, Stengel B, Fouqueray B NephroTest Study Group: Timing of onset of CKD-related metabolic complications. J Am Soc Nephrol 20: 164-171, 2009
16. Lipschitz DA, Cook JD, Finch CA: A clinical evaluation of serum ferritin as an index of iron stores. 1974. Nutrition 8: 443-447, discussion 448, 1992
17. Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P: Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 16: 763-773, 2005
18. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostetter TH, Lameire N, Eknoyan G: Definition andclassification of chronickidney disease: A positionstatement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 67: 2089-2100, 2005
19. Belonje AMS, Voors AA, van der Meer P, van Gilst WH, Jaarsma T, van Veldhuisen DJ: Endogenous erythropoietin and outcome in heart failure. Circulation 121: 245-251, 2010
20. van der Meer P, Lok DJ, Januzzi JL, de la Porte PW, Lipsic E, van Wijngaarden J, Voors AA, van Gilst WH, van Veldhuisen DJ: Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. Eur Heart J 29: 1510-1515, 2008
21. Opasich C, Cazzola M, Scelsi L, De Feo S, Bosimini E, Lagioia R, Febo O, Ferrari R, Fucili A, Moratti R, Tramarin R, Tavazzi L: Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. Eur Heart J 26: 2232-2237, 2005
22. Bray GL, Taylor B, O'Donnell R: Comparison of the erythropoi-etin response in children with aplastic anemia, transient eryth-roblastopenia, and iron deficiency. J Pediatr 120: 528-532, 1992
23. Joosten E, Van Hove L, Lesaffre E, Goossens W, Dereymaeker L, Van Goethem G, Pelemans W: Serum erythropoietin levels in elderly inpatients with anemia of chronic disorders and iron deficiency anemia. J Am Geriatr Soc 41: 1301-1304, 1993
24. Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G: Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood 107: 4142-4148, 2006
25. Teruel JL, Marcen R, Navarro JF, Villafruela JJ, Fernandez Lucas M, Rivera M, Ortuño J: Influence of body iron stores on the serum erythropoietin concentration in hemodialyzed patients. Am J Nephrol 14: 95-98, 1994
26. Nemeth E: Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias. Adv Hematol 2010: 750643, 2010
27. Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman R, Maxwell PH, Choi P: Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica 95: 505-508, 2010
28. Srai SK, Chung B, Marks J, Pourvali K, Solanky N, Rapisarda C, Chaston TB, Hanif R, Unwin RJ, Debnam ES, Sharp PA: Eryth-ropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. Kidney Int 78: 660-667, 2010
29. Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN: Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood 116: 97-108, 2010
30. Forejtnikovà H, Vieillevoye M, Zermati Y, Lambert M, Pellegrino RM, Guihard S, Gaudry M, Camaschella C, Lacombe C, Roetto A, Mayeux P, Verdier F: Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood 116: 5357-5367, 2010
31. Ausk KJ, Ioannou GN: Is obesity associated with anemia of chronic disease? A population-based study. Obesity (Silver Spring) 16: 2356-2361, 2008
32. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, Braunschweig C: Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring) 18: 1449-1456, 2010
33. Biaggioni I, Robertson D, Krantz S, Jones M, Haile V: The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med 121: 181-186, 1994
34. Bosman DR, Winkler AS, Marsden JT, Macdougall IC, Watkins PJ: Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care 24: 495-499, 2001
35. Wagner M, Alam A, Zimmermann J, Rauh K, Koljaja-Batzner A, Raff U, Wanner C, Schramm L: Endogenous erythropoietin and the association with inflammation and mortality in diabetic chronic kidney disease. Clin J Am Soc Nephrol 6: 1573-1579, 2011
36. Faquin WC, Schneider TJ, Goldberg MA: Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79: 1987-1994, 1992
37. Fandrey J, Jelkmann WE: Interleukin-1 and tumor necrosis factor-alpha inhibit erythropoietin production in vitro. Ann N Y Acad Sci 628: 250-255, 1991
38. Congote LF, Sadvakassova G, Dobocan MC, Difalco MR, Li Q: Erythropoietin-dependent endothelial proteins: Potential use against erythropoietin resistance. Cytokine 51: 113-118, 2010
39. Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A: Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood 87: 4824-4830, 1996
40. Corazza F, Beguin Y, Bergmann P, André M, Ferster A, Devalck C, Fondu P, Buyse M, Sariban E: Anemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production. Blood 92: 1793-1798, 1998
41. Spivak JL, Barnes DC, Fuchs E, Quinn TC: Serum immunoreactive erythropoietin in HIV-infected patients. JAMA 261: 3104-3107, 1989
42. Solomon SD, Uno H, Lewis EF, Eckardt KU, Lin J, Burdmann EA, de Zeeuw D, Ivanovich P, Levey AS, Parfrey P, Remuzzi G, Singh AK, Toto R, Huang F, Rossert J, McMurray JJ, Pfeffer MA Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) Investigators: Erythropoietic response and outcomes in kidney disease and type 2 diabetes. N Engl J Med 363: 1146-1155, 2010