The Effect of Spironolactone on the Incidence of Contrast-Induced Nephropathy in Patients Undergoing Cardiac Catheterization: Study Design and Rationale

Cardiology and Therapy

Volumn 7, Issue 1, 2018, Pages 101-106

  Mujtaba, Alhasan ^a   Taher, Mohammed A ^a   Hazza, Mazin A ^b   Al Rubaye, Hassan M ^c   Kata, Asaad H ^c   AbdulWahab, Hamid ^c   AbdulBari, AbdulAmeer ^b   AlRubay, Hayder K ^d  

^a UNIVERSITY OF BAGHDAD   (Iraq)

^b UNIVERSITY OF BASRAH   (Iraq)

^c Basra Cardiac Catheterization Center   (Iraq)

^d BAGHDAD TEACHING HOSPITAL   (Iraq)

Author keywords

Acute kidney injury (AKI); Aldactone; Angiography; Angioplasty; Contrast induced nephropathy (CIN); Ischemic heart disease (IHD); Percutaneous coronary angiography (PCI); Spironolactone

Indexed keywords

CREATININE; METFORMIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PLACEBO; POTASSIUM; SPIRONOLACTONE;

ADULT; ARTICLE; CONTRAST INDUCED NEPHROPATHY; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; HEART CATHETERIZATION; HEMATOCRIT; HIGH RISK PATIENT; HUMAN; HYPERKALEMIA; MAJOR CLINICAL STUDY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE;

EID: 85083070640     PISSN: 21938261     EISSN: 21936544     Source Type: Journal    
DOI: 10.1007/s40119-018-0112-3     Document Type: Article

References (24)

1. Tehrani S, et al. Contrast-induced acute kidney injury following PCI. Eur J Clin Invest. 2013;43:483–90.
2. Tziakas D, et al. Validation of a new risk score to predict contrast-induced nephropathy after percutaneous coronary intervention. Am J Cardiol. 2014;113:1487–93.
3. Sadeghi HM, Stone GW, Grines CL, et al. Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction. Circulation. 2003;108:2769–75.
4. Liu M, et al. Aggressive hydraTion in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention to prevent contrast-induced nephropathy (ATTEMPT): study design and protocol for the randomized, controlled trial, the ATTEMPT, RESCIND 1 (First study for REduction of contraSt-induCed nephropathy following carDiac catheterization) trial. Am Heart J. 2016;172:88–95.
5. Droppa M, Desch S, Blase P, et al. Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty. Clin Res Cardiol. 2011;100:1037–43.
6. Thayssen P, Lassen JF, Jensen SE, et al. Prevention of contrast-induced nephropathy with N-acetylcysteine or sodium bicarbonate in patients with ST-segment-myocardial infarction: a prospective, randomized, open-labeled trial. Circ Cardiovasc Interv. 2014;7:216–24.
7. Navarro RB, et al. The effect of spironolactone on acute kidney injury after cardiac surgery: a randomized, placebo-controlled trial. Am J Kidney Dis. 2016. 10.1053/j.ajkd.2016.06.013.
8. Mejia-Vilet JM, et al. Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol. 2007;293:F78–86.
9. Sanchez-Pozos K, et al. Recovery from ischemic acute kidney injury by spironolactone administration. Nephrol Dial Transplant. 2012;27:3160–9.
10. Pretorius M, et al. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med. 2012;40(10):2805–12.
11. Briguori C, et al. Cystatin C and contrast-induced acute kidney injury. Circulation. 2010;121:2117–22.
12. Kellum JA, Lameire N, Aspelin P, Barsoum RS, Burdmann EA, Goldstein SL, Herzog CA, Joannidis M, Kribben A, Levey AS, MacLeod AM, Mehta RL, Murray PT, Naicker S, Opal SM, Schaefer F, Schetz M, Uchino S. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012;2:1–138.
13. Tong J, et al. Neutrophil gelatinase-associated lipocalin in the prediction of contrast-induced nephropathy: a systematic review and meta-analysis. J Cardiovasc Pharmacol. 2015;66:239–45.
14. Sarwar CM, Papadimitriou L, Pitt B, et al. Hyperkalemia in heart failure. J Am Coll Cardiol. 2016;68(14):1575–89.
15. Butler J, Anstrom KJ, Feller M, et al. Efficacy and safety of spironolactone in acute heart failure: the ATHENA-HF randomized clinical trial. JAMA Cardiol. 2017. 10.1001/jamacardio.2017.2198.
16. Al-Tu’ma FJ, et al. The role of serum cystatin C in the early detection of contrast-induced nephropathy after coronary intervention. J Kidney. 2017;3:154. 10.4172/2472-1220.1000154.
17. Nassir FS. Contrast-induced nephropathy in diabetic and non-diabetic patients after coronary intervention. J Babylon Univ/Pure Appl Sci. 2014;22(9):2530–46.
18. Taher, et al. Predicting contrast-induced nephropathy post coronary intervention: a prospective cohort study. Egypt Heart J. 2015;67:337–43.
19. Silver SA, et al. Risk prediction models for contrast-induced nephropathy: systematic review. BMJ. 2015;351:h4395.
20. Dong Y, et al. How strong is the evidence for sodium bicarbonate to prevent contrast-induced acute kidney injury after coronary angiography and percutaneous coronary intervention? Medicine. 2016;95(7):e2715.
21. Brar SS, et al. Haemodynamic-guided fluid administration for the prevention of contrast-induced acute kidney injury: the POSEIDON randomised controlled trial. Lancet. 2014;383(9931):1814–23.
22. Butler J, et al. Rationale and design of the aldosterone targeted neurohormonal combined with natriuresis therapy in heart failure (ATHENA-HF) trial. JACC Heart Fail. 2016;4(9):726–35.
23. Ferreira JP, Santos M, Almeida S, Marques I, Bettencourt P, Carvalho H. Mineralocorticoid receptor antagonism in acutely decompensated chronic heart failure. Eur J Intern Med. 2014;25:67–72.
24. McInnes CT, et al. Spironolactone dose–response relationships in healthy subjects. Br J Clin Pharm. 1982;13:513–8.