Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

EBioMedicine

Volumn 55, Issue , 2020, Pages

  Liu, Jing ^a,c   Li, Sumeng ^a,c   Liu, Jia ^a,c   Liang, Boyun ^a,c   Wang, Xiaobei ^a   Wang, Hua ^a   Li, Wei ^a,c   Tong, Qiaoxia ^a,c   Yi, Jianhua ^a,c   Zhao, Lei ^a,c   Xiong, Lijuan ^a,c   Guo, Chunxia ^a,c   Tian, Jin ^a,c   Luo, Jinzhuo ^a,c   Yao, Jinghong ^a,c   Pang, Ran ^a,c   Shen, Hui ^a,c   Peng, Cheng ^a,c   Liu, Ting ^a,c   Zhang, Qian ^a,c   Wu, Jun ^a,c   Xu, Ling ^a,c   Lu, Sihong ^a,c   Wang, Baoju ^a,c   Weng, Zhihong ^a,c   Han, Chunrong ^a,c   Zhu, Huabing ^a,c   Zhou, Ruxia ^a,c   Zhou, Helong ^a,c   Chen, Xiliu ^a,c   Ye, Pian ^a,c   Zhu, Bin ^a,c   Wang, Lu ^a,c   Zhou, Wenqing ^a,c   He, Shengsong ^a,c   He, Yongwen ^a,c   Jie, Shenghua ^a,c   Wei, Ping ^a,c   Zhang, Jianao ^a,c   Lu, Yinping ^a,c   Wang, Weixian ^a,c   Zhang, Li ^a,c   Li, Ling ^a,c   Zhou, Fengqin ^a,c   Wang, Jun ^b,c   Dittmer, Ulf ^b,c   Lu, Mengji ^b,c   Hu, Yu ^a   Yang, Dongliang ^a,c   Zheng, Xin ^a,c   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Coronavirus; COVID 19; Inflammatory cytokine; Lymphopenia; SARS CoV 2

Indexed keywords

ABIDOL; ALANINE AMINOTRANSFERASE; ALPHA2B INTERFERON; AMYLOID A PROTEIN; ANTIVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; CEPHALOSPORIN; CREATINE KINASE; CYTOKINE; D DIMER; FERRITIN; FIBRINOGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; MOXIFLOXACIN; OSELTAMIVIR; PENICILLIN DERIVATIVE; RIBAVIRIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CHEMILUMINESCENCE IMMUNOASSAY; CLINICAL ARTICLE; COHORT ANALYSIS; CORONAVIRUS DISEASE 2019; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MALE; MIDDLE AGED; MIXED INFECTION; MYALGIA; MYCOSIS; NAUSEA; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SPUTUM; AGED; BETACORONAVIRUS; BLOOD; CHINA; COMORBIDITY; COMPLICATION; CORONAVIRUS INFECTION; CYTOKINE RELEASE SYNDROME; IMMUNOLOGY; LEUKOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; NEUTROPHIL; PANDEMIC; TIME FACTOR; VIRUS PNEUMONIA;

ADULT; AGED; BETACORONAVIRUS; CD8-POSITIVE T-LYMPHOCYTES; CHINA; COMORBIDITY; CORONAVIRUS INFECTIONS; CYTOKINE RELEASE SYNDROME; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOPENIA; MALE; MIDDLE AGED; NEUTROPHILS; PANDEMICS; PNEUMONIA, VIRAL; PROGNOSIS; TIME FACTORS;

EID: 85081132231     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2020.102763     Document Type: Article

References (19)

1. World Health Organization. Coronavirus disease (COVID-19) outbreak situation. 2020. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed March 26, 2020.
2. National Health Commission of the People's Republic Of China. Update on the epidemic situation of novel coronavirus pneumonia as of 24:00 on March 25. Available at: http://www.nhc.gov.cn/xcs/yqfkdt/202003/f01fc26a8a7b48debe194bd1277fdba3.shtml. Accessed March 26, 2020.
3. Huang, C., Wang, Y., Li, X., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:10223 (2020), 514–523.
4. Chan, J.F., Yuan, S., Kok, K.H., et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 395:10223 (2020), 514–523.
5. Wang, D., Hu, B., Hu, C., et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 395:10223 (2020), 514–523.
6. de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol 14:8 (2016), 523–534.
7. Chien, J.Y., Hsueh, P.R., Cheng, W.C., Yu, C.J., Yang, P.C., Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology 11:6 (2006), 715–722.
8. Chen, N., Zhou, M., Dong, X., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395:10223 (2020), 507–513.
9. Qin, C., Zhou, L., Hu, Z., et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis, 2020.
10. Chen, G., Wu, D., Guo, W., et al. Clinical and immunologic features in severe and moderate coronavirus disease 2019. J Clin Invest, 2020.
11. Chang, D., Lin, M., Wei, L., et al. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. JAMA, 323(11), 2020, 1092.
12. Chu, H., Zhou, J., Wong, B.H., et al. Productive replication of middle east respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. Virology 454 (2014), 197–205.
13. Zhou, J., Chu, H., Li, C., et al. Active replication of middle east respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis. J Infect Dis 209:9 (2014), 1331–1342.
14. Kong, S.L., Chui, P., Lim, B., Salto-Tellez, M., Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Virus Res 145:2 (2009), 260–269.
15. Kim, K.D., Zhao, J., Auh, S., et al. Adaptive immune cells temper initial innate responses. Nat Med 13:10 (2007), 1248–1252.
16. Palm, N.W., Medzhitov, R., Not so fast: adaptive suppression of innate immunity. Nat Med 13:10 (2007), 1142–1144.
17. Liu, J., Liu, Y., Xiang, P., et al. Neutrophil-to-lymphocyte ratio predicts severe illness patients with 2019 novel coronavirus in the early stage. medRxiv, 2020, 10.1101/2020.02.10.20021584 [Preprint]. February 12, 2020 [cited 2020 Feb 16]. Available from:.
18. Wang, F., Nie, J., Wang, H., et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis, 2020.
19. Channappanavar, R., Perlman, S., Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol 39:5 (2017), 529–539.