Statement in relation to the safety of erythritol (E 968) in light of new data, including a new paediatric study on the gastrointestinal tolerability of erythritol

EFSA Journal

Volumn 8, Issue 7, 2010, Pages

[No Author Info available]

Author keywords

Erythritol; gastrointestinal tolerability; laxation; paediatric study

Indexed keywords

EID: 85078375432     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2010.1650     Document Type: Article

References (19)

1. Bornet FRJ, Blayo A, Dauchy F, Slama G, 1996a. Plasma and urine kinetics of erythritol after oral ingestion by healthy humans. Regul Toxicol Pharmacol 24(2, Part 2), S280–S285.
2. Bornet FRJ, Blayo A, Dauchy F, Slama G, 1996b. Gastrointestinal response and plasma and urine determinations in human subjects given erythritol. Regul Toxicol Pharmacol 24(2, Part 2), S296–S302.
3. COT, 2003. Erythritol. Discussion Paper. Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment. TOX/2003/38. October 21, 2003. www.food.gov.uk/multimedia/pdfs/TOX-2003-38.PDF.
4. COT, 2004. Erythritol. Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment. Annual Report 2004, p.10.
5. De Cock P, Bechert C-L, 2002. Erythritol. Functionality in nonclaroic functional beverages. Pure Appl Chem 74(7), 1281–1289.
6. Hulshof KFAM, 1997. Estimated consumption for the food ingredient erythritol. TNO report V97.650 (unpublished) (CONFIDENTIAL).
7. Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N, Modderman J, 1996. Effects of oral administration of erythritol on patients with diabetes. Regul Toxicol Pharmacol 24(2, Part 2), S303–S308.
8. JECFA, 2000. Safety Additive Series, No 44. pp. 15–70. Evaluation of certain food additives and contaminants. WHO Food.
9. Lee A, Wils D, Zumbé A, Storey DM, 2002. The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC. Eur J Clin Nutr 56(8), 755–764.
10. Lifshitz F, Ament ME, Kleinman RE, Klish W, Lebenthal E, Perman J, Udall JN (Jr.), 1992. Role of juice carbohydrate malabsorption in chronic nonspecific diarrhea in children. J Pediatr 120(5), 825–829.
11. Munro IC, Berndt WO, Borzelleca JF, Flamm G, Lynch BS, Kennepohl E, Bar EA, Modderman J, 1998. Erythritol: An interpretive summary of biochemical, metabolic, toxicological and clinical data. Food Chem Toxicol 36(12), 1139–1174.
12. Oku T, Okazaki M, 1996. Laxative threshold of sugar alcohol erythritol in human subjects. Nutr Res 16(4), 577–589.
13. Perko, 2006. Erythritol. In: Sweeteners and sugar alternatives in food technology. June 2006, Oxford, UK.
14. SCF, 2003. Opinion of the Scientific Committee on Food on Erythritol. European Commission, Health and Consumer Protection Directorate-General. SCF/CS/ADD/EDUL/215 Final. Opinion expressed on 5 March, 2003. ec.europa.eu/food/fs/sc/scf/out175_en.pdf.
15. Storey DM, Lee A, Bornet F, Brouns F, 2007. Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid. Eur J Clin Nutr 61,349–354.
16. Takahashi C, 1992a. Study on the Maximum No Effect Level of Erythritol Using Transient Diarrheal Action as Index. Nikken Chemicals Co., Ltd.; Japan. [Internal Report] (CONFIDENTIAL).
17. Takahashi C, 1992b. The Effect of Continuous Injection of Erythritol With Laxative Action Serving as Index. Nikken Chemicals Co., Ltd.; Japan. [Internal Report] (CONFIDENTIAL).
18. Tetzloff W, Dauchy F, Medimagh S, Carr D, Bär A, 1996. Tolerance to subchronic, high dose ingestion of erythritol in human volunteers. Regul Toxicol Pharmacol 24(2, Part 2), S286–S295.
19. Umeki Y, 1992. Study Concerning Transient Diarrhea. Mitsubishi Kasei Corporation, Food Business Department. [Internal Report] (CONFIDENTIAL).