메뉴 건너뛰기




Volumn 2017, Issue 1, 2017, Pages 1-16

OncoKB: A precision oncology knowledge base

(48)  Chakravarty, Debyani a   Gao, Jianjiong a   Phillips, Sarah a   Kundra, Ritika a   Zhang, Hongxin a   Wang, Jiaojiao a   Rudolph, Julia E a   Yaeger, Rona a   Soumerai, Tara a   Nissan, Moriah H a   Chang, Matthew T a   Chandarlapaty, Sarat a,b   Traina, Tiffany A a   Paik, Paul K a,b   Ho, Alan L a   Hantash, Feras M c   Grupe, Andrew c   Baxi, Shrujal S a,b   Callahan, Margaret K a,b   Snyder, Alexandra a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CANCER PROGNOSIS; CANCER THERAPY; CANCER TISSUE; COPY NUMBER VARIATION; DRUG LABELING; DRUG RESPONSE; EVIDENCE BASED MEDICINE; FACTUAL DATABASE; FOOD AND DRUG ADMINISTRATION; GENE FUSION; GENE MUTATION; HUMAN; INTERNET; MEDICAL DECISION MAKING; MEDICAL EXPERT; ONCOKB; PERSONALIZED MEDICINE; PREDICTION; PRIORITY JOURNAL; SCIENTIFIC LITERATURE; SOMATIC MUTATION;

EID: 85077486246     PISSN: None     EISSN: 24734284     Source Type: Journal    
DOI: 10.1200/PO.17.00011     Document Type: Article
Times cited : (1673)

References (100)
  • 1
    • 84884994218 scopus 로고    scopus 로고
    • The Cancer Genome Atlas pan-cancer analysis project
    • Weinstein JN, Collisson EA, Mills GB, et al: The Cancer Genome Atlas pan-cancer analysis project. Nat Genet 45: 1113-1120, 2013
    • (2013) Nat Genet , vol.45 , pp. 1113-1120
    • Weinstein, J.N.1    Collisson, E.A.2    Mills, G.B.3
  • 2
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • [Erratum: Nature 465:966, 2010]
    • Hudson TJ, Anderson W, Artez A, et al: International network of cancer genome projects. Nature 464:993-998, 2010 [Erratum: Nature 465:966, 2010]
    • (2010) Nature , vol.464 , pp. 993-998
    • Hudson, T.J.1    Anderson, W.2    Artez, A.3
  • 3
    • 85077486568 scopus 로고    scopus 로고
    • Vanderbilt-Ingram Cancer Center: My cancer genome. https://www.mycancergenome.org
  • 4
    • 85011275698 scopus 로고    scopus 로고
    • CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
    • Griffith M, Spies NC, Krysiak K, et al: CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. Nat Genet 49:170-174, 2017
    • (2017) Nat Genet , vol.49 , pp. 170-174
    • Griffith, M.1    Spies, N.C.2    Krysiak, K.3
  • 5
    • 85077480864 scopus 로고    scopus 로고
    • The McDonnell Genome Institute: CIViC: Clinical interpretations of variants in cancer. https://civic.genome. wustl.edu
  • 6
    • 85019771721 scopus 로고    scopus 로고
    • The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations
    • [epub ahead of print on October 27, 2016]
    • Huang L, Fernandes H, Zia H, et al: The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations. J Am Med Inform Assoc 10.1093/jamia/ocw148 [epub ahead of print on October 27, 2016]
    • J Am Med Inform Assoc
    • Huang, L.1    Fernandes, H.2    Zia, H.3
  • 7
    • 85077486927 scopus 로고    scopus 로고
    • Institute of Precision Medicine: Welcome to the PrecisionMedicine Knowledgebase. https://pmkb.weill.cornell.edu
  • 8
    • 84954349452 scopus 로고    scopus 로고
    • The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies
    • Patterson SE, Liu R, Statz CM, et al: The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies. Hum Genomics 10:4, 2016
    • (2016) Hum Genomics , vol.10 , pp. 4
    • Patterson, S.E.1    Liu, R.2    Statz, C.M.3
  • 9
    • 85077482561 scopus 로고    scopus 로고
    • The Jackson Laboratory: Clinical Knowledgebase (CKB). https://www.jax.org/clinical-genomics/ckb
  • 10
    • 85077481418 scopus 로고    scopus 로고
    • Barcelona Biomedical Genomics Lab: Cancer genome interpreter. https://cancergenomeinterpreter.org
  • 11
    • 84952663305 scopus 로고    scopus 로고
    • Cancer driver log (CanDL): Catalog of potentially actionable cancer mutations
    • Damodaran S, Miya J, Kautto E, et al: Cancer driver log (CanDL): Catalog of potentially actionable cancer mutations. J Mol Diagn 17:554-559, 2015
    • (2015) J Mol Diagn , vol.17 , pp. 554-559
    • Damodaran, S.1    Miya, J.2    Kautto, E.3
  • 12
    • 85077489634 scopus 로고    scopus 로고
    • The Ohio State University: CanDL. http://candl.osu.edu
  • 13
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • Lawrence MS, Stojanov P, Mermel CH, et al: Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505:495-501, 2014
    • (2014) Nature , vol.505 , pp. 495-501
    • Lawrence, M.S.1    Stojanov, P.2    Mermel, C.H.3
  • 14
    • 85077490556 scopus 로고    scopus 로고
    • Broad Institute: Welcome to TumorPortal: Genes, cancers, DNAmutations and annotations. http://tumorportal.org
  • 15
    • 85077483167 scopus 로고    scopus 로고
    • Massachusetts General Hospital: Targeted cancer care. https://targetedcancercare.massgeneral.org
  • 16
    • 84938209813 scopus 로고    scopus 로고
    • A decision support framework for genomically informed investigational cancer therapy
    • Meric-Bernstam F, Johnson A, Holla V, et al: A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst 107:dvj098, 2015
    • (2015) J Natl Cancer Inst , vol.107
    • Meric-Bernstam, F.1    Johnson, A.2    Holla, V.3
  • 18
    • 85077489237 scopus 로고    scopus 로고
    • Memorial Sloan Kettering Cancer Center: Cancer hotspots. http://cancerhotspots.org
    • Cancer hotspots
  • 19
    • 85077485806 scopus 로고    scopus 로고
    • OncoKB
    • Memorial Sloan Kettering Cancer Center: OncoKB. http://oncokb.org
  • 20
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401-404, 2012
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 21
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao J, Aksoy BA, Dogrusoz U, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6:pl1, 2013
    • (2013) Sci Signal , vol.6 , pp. pl1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3
  • 23
    • 84942319957 scopus 로고    scopus 로고
    • BRAF mutants evade ERK-Dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition
    • Yao Z, Torres NM, Tao A, et al: BRAF mutants evade ERK-Dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition. Cancer Cell 28:370-383, 2015
    • (2015) Cancer Cell , vol.28 , pp. 370-383
    • Yao, Z.1    Torres, N.M.2    Tao, A.3
  • 24
    • 84866342282 scopus 로고    scopus 로고
    • BRAF(L597) mutations in melanoma are associated with sensitivity toMEK inhibitors
    • Dahlman KB, Xia J, HutchinsonK, et al: BRAF(L597) mutations in melanoma are associated with sensitivity toMEK inhibitors. Cancer Discov 2:791-797, 2012
    • (2012) Cancer Discov , vol.2 , pp. 791-797
    • Dahlman, K.B.1    Xia, J.2    Hutchinson, K.3
  • 25
    • 84926131772 scopus 로고    scopus 로고
    • Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma
    • Bowyer SE, Rao AD, Lyle M, et al: Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma. Melanoma Res 24:504-508, 2014
    • (2014) Melanoma Res , vol.24 , pp. 504-508
    • Bowyer, S.E.1    Rao, A.D.2    Lyle, M.3
  • 26
    • 84874777853 scopus 로고    scopus 로고
    • Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
    • Kim KB, Kefford R, Pavlick AC, et al: Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 31: 482-489, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 482-489
    • Kim, K.B.1    Kefford, R.2    Pavlick, A.C.3
  • 27
    • 84938815085 scopus 로고    scopus 로고
    • Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
    • Paik PK, Drilon A, Fan PD, et al: Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov 5:842-849, 2015
    • (2015) Cancer Discov , vol.5 , pp. 842-849
    • Paik, P.K.1    Drilon, A.2    Fan, P.D.3
  • 28
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • [Erratum: Nature 514:262, 2014]
    • Cancer Genome Atlas Research Network: Comprehensive molecular profiling of lung adenocarcinoma. Nature 511: 543-550, 2014 [Erratum: Nature 514:262, 2014]
    • (2014) Nature , vol.511 , pp. 543-550
  • 29
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
    • Ma PC, Jagadeeswaran R, Jagadeesh S, et al: Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 65:1479-1488, 2005
    • (2005) Cancer Res , vol.65 , pp. 1479-1488
    • Ma, P.C.1    Jagadeeswaran, R.2    Jagadeesh, S.3
  • 30
    • 0141988690 scopus 로고    scopus 로고
    • c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions
    • MaPC, Kijima T, Maulik G, et al: c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 63:6272-6281, 2003
    • (2003) Cancer Res , vol.63 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3
  • 31
    • 84938805958 scopus 로고    scopus 로고
    • Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
    • Frampton GM, Ali SM, Rosenzweig M, et al: Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov 5:850-859, 2015
    • (2015) Cancer Discov , vol.5 , pp. 850-859
    • Frampton, G.M.1    Ali, S.M.2    Rosenzweig, M.3
  • 32
    • 84871351824 scopus 로고    scopus 로고
    • NSCLC-H, version 3.2017
    • National Comprehensive Cancer Network: Non-small cell lung cancer, NSCLC-H, version 3.2017. http://www. nccn.org
    • Non-small cell lung cancer
  • 33
    • 84942515816 scopus 로고    scopus 로고
    • Targeted therapy for patients with BRAF-mutant lung cancer: Results from the European EURAF cohort
    • Gautschi O, Milia J, Cabarrou B, et al: Targeted therapy for patients with BRAF-mutant lung cancer: Results from the European EURAF cohort. J Thorac Oncol 10:1451-1457, 2015
    • (2015) J Thorac Oncol , vol.10 , pp. 1451-1457
    • Gautschi, O.1    Milia, J.2    Cabarrou, B.3
  • 34
    • 84939864059 scopus 로고    scopus 로고
    • Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
    • Hyman DM, Puzanov I, Subbiah V, et al: Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 373:726-736, 2015
    • (2015) N Engl J Med , vol.373 , pp. 726-736
    • Hyman, D.M.1    Puzanov, I.2    Subbiah, V.3
  • 35
    • 84991059363 scopus 로고    scopus 로고
    • Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: An open-label, multicentre phase 2 trial
    • Planchard D, Besse B, Groen HJ, et al: Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: An open-label, multicentre phase 2 trial. Lancet Oncol 17:984-993, 2016
    • (2016) Lancet Oncol , vol.17 , pp. 984-993
    • Planchard, D.1    Besse, B.2    Groen, H.J.3
  • 36
    • 67649933709 scopus 로고    scopus 로고
    • Mutational analysis of the BRAF gene in transitional cell carcinoma of the bladder
    • Boulalas I, Zaravinos A, Delakas D, et al: Mutational analysis of the BRAF gene in transitional cell carcinoma of the bladder. Int J Biol Markers 24:17-21, 2009
    • (2009) Int J Biol Markers , vol.24 , pp. 17-21
    • Boulalas, I.1    Zaravinos, A.2    Delakas, D.3
  • 37
    • 65549094095 scopus 로고    scopus 로고
    • Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors
    • Honecker F, Wermann H, Mayer F, et al: Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. J Clin Oncol 27:2129-2136, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 2129-2136
    • Honecker, F.1    Wermann, H.2    Mayer, F.3
  • 38
    • 84951810474 scopus 로고    scopus 로고
    • Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer
    • Kopetz S, Desai J, Chan E, et al: Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer. J Clin Oncol 33:4032-4038, 2015
    • (2015) J Clin Oncol , vol.33 , pp. 4032-4038
    • Kopetz, S.1    Desai, J.2    Chan, E.3
  • 39
    • 84927604543 scopus 로고    scopus 로고
    • Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients
    • Yaeger R, Cercek A, O'Reilly EM, et al: Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients. Clin Cancer Res 21:1313-1320, 2015
    • (2015) Clin Cancer Res , vol.21 , pp. 1313-1320
    • Yaeger, R.1    Cercek, A.2    O'Reilly, E.M.3
  • 40
    • 84862738897 scopus 로고    scopus 로고
    • Preclinical pharmacology of AZD5363, an inhibitor of AKT: Pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background
    • Davies BR, Greenwood H, Dudley P, et al: Preclinical pharmacology of AZD5363, an inhibitor of AKT: Pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther 11:873-887, 2012
    • (2012) Mol Cancer Ther , vol.11 , pp. 873-887
    • Davies, B.R.1    Greenwood, H.2    Dudley, P.3
  • 41
    • 84957955911 scopus 로고    scopus 로고
    • Tumors with AKT1E17K mutations are rational targets for single agent or combination therapy with AKT inhibitors
    • Davies BR, Guan N, Logie A, et al: Tumors with AKT1E17K mutations are rational targets for single agent or combination therapy with AKT inhibitors. Mol Cancer Ther 14:2441-2451, 2015
    • (2015) Mol Cancer Ther , vol.14 , pp. 2441-2451
    • Davies, B.R.1    Guan, N.2    Logie, A.3
  • 42
    • 85014559729 scopus 로고    scopus 로고
    • Abstract B109: AZD5363, a catalytic pan-Akt inhibitor, in Akt1 E17K mutation positive advanced solid tumors
    • Hyman DM, Smyth L, Bedard PL, et al: Abstract B109: AZD5363, a catalytic pan-Akt inhibitor, in Akt1 E17K mutation positive advanced solid tumors. Mol Cancer Ther 14:B109, 2015
    • (2015) Mol Cancer Ther , vol.14 , pp. B109
    • Hyman, D.M.1    Smyth, L.2    Bedard, P.L.3
  • 43
    • 31544449750 scopus 로고    scopus 로고
    • Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
    • Lee JW, Soung YH, Seo SH, et al: Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res 12:57-61, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 57-61
    • Lee, J.W.1    Soung, Y.H.2    Seo, S.H.3
  • 44
    • 84873918443 scopus 로고    scopus 로고
    • Activating HER2 mutations in HER2 gene amplification negative breast cancer
    • Bose R, Kavuri SM, Searleman AC, et al: Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 3:224-237, 2013
    • (2013) Cancer Discov , vol.3 , pp. 224-237
    • Bose, R.1    Kavuri, S.M.2    Searleman, A.C.3
  • 45
    • 85012034846 scopus 로고    scopus 로고
    • Abstract PD5-05: Neratinib for ERBB2 mutant, HER2 non-amplified, metastatic breast cancer: Preliminary analysis from a multicenter, open-label, multi-histology phase II basket trial
    • Hyman D, Piha-Paul S, Rodón J, et al: Abstract PD5-05: Neratinib for ERBB2 mutant, HER2 non-amplified, metastatic breast cancer: Preliminary analysis from a multicenter, open-label, multi-histology phase II basket trial. Cancer Res 76:PD5-05, 2016
    • (2016) Cancer Res , vol.76 , pp. PD5-PD05
    • Hyman, D.1    Piha-Paul, S.2    Rodón, J.3
  • 46
    • 84875804031 scopus 로고    scopus 로고
    • Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models
    • Lin J, Sampath D, Nannini MA, et al: Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res 19:1760-1772, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 1760-1772
    • Lin, J.1    Sampath, D.2    Nannini, M.A.3
  • 47
    • 85009738988 scopus 로고    scopus 로고
    • PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
    • de Bono JS, De Giorgi U, Massard C, et al: PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC). Ann Oncol 27:243-265, 2016
    • (2016) Ann Oncol , vol.27 , pp. 243-265
    • de Bono, J.S.1    De Giorgi, U.2    Massard, C.3
  • 48
    • 84868195516 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus in patients with metastatic breast cancer
    • Fleming GF, Ma CX, Huo D, et al: Phase II trial of temsirolimus in patients with metastatic breast cancer. Breast Cancer Res Treat 136:355-363, 2012
    • (2012) Breast Cancer Res Treat , vol.136 , pp. 355-363
    • Fleming, G.F.1    Ma, C.X.2    Huo, D.3
  • 49
    • 84964318224 scopus 로고    scopus 로고
    • A phase I trial of BKM120 (buparlisib) in combination with fulvestrant in postmenopausal women with estrogen receptor-positive metastatic breast cancer
    • Ma CX, Luo J, Naughton M, et al: A phase I trial of BKM120 (buparlisib) in combination with fulvestrant in postmenopausal women with estrogen receptor-positive metastatic breast cancer. Clin Cancer Res 22:1583-1591, 2016
    • (2016) Clin Cancer Res , vol.22 , pp. 1583-1591
    • Ma, C.X.1    Luo, J.2    Naughton, M.3
  • 50
    • 84904555503 scopus 로고    scopus 로고
    • Phase I dose-escalation and-expansion study of buparlisib (BKM120), an oral panclass I PI3K inhibitor, in patients with advanced solid tumors
    • Rodon J, Brana I, Siu LL, et al: Phase I dose-escalation and-expansion study of buparlisib (BKM120), an oral panclass I PI3K inhibitor, in patients with advanced solid tumors. Invest New Drugs 32:670-681, 2014
    • (2014) Invest New Drugs , vol.32 , pp. 670-681
    • Rodon, J.1    Brana, I.2    Siu, L.L.3
  • 51
    • 84890554032 scopus 로고    scopus 로고
    • Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: A GINECO group study
    • Trédan O, Treilleux I, Wang Q, et al: Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: A GINECO group study. Target Oncol 8:243-251, 2013
    • (2013) Target Oncol , vol.8 , pp. 243-251
    • Trédan, O.1    Treilleux, I.2    Wang, Q.3
  • 52
    • 52449131427 scopus 로고    scopus 로고
    • PTEN loss does not predict for response to RAD001 (everolimus) in a glioblastoma orthotopic xenograft test panel
    • Yang L, Clarke MJ, Carlson BL, et al: PTEN loss does not predict for response to RAD001 (everolimus) in a glioblastoma orthotopic xenograft test panel. Clin Cancer Res 14:3993-4001, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 3993-4001
    • Yang, L.1    Clarke, M.J.2    Carlson, B.L.3
  • 53
    • 84899513979 scopus 로고    scopus 로고
    • Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
    • Nissan MH, Pratilas CA, Jones AM, et al: Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res 74:2340-2350, 2014
    • (2014) Cancer Res , vol.74 , pp. 2340-2350
    • Nissan, M.H.1    Pratilas, C.A.2    Jones, A.M.3
  • 54
    • 84940961649 scopus 로고    scopus 로고
    • Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: Clinical outcomes and response to erlotinib
    • Naidoo J, Sima CS, Rodriguez K, et al: Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: Clinical outcomes and response to erlotinib. Cancer 121:3212-3220, 2015
    • (2015) Cancer , vol.121 , pp. 3212-3220
    • Naidoo, J.1    Sima, C.S.2    Rodriguez, K.3
  • 55
    • 84892631191 scopus 로고    scopus 로고
    • Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
    • Yasuda H, Park E, Yun CH, et al: Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med 5:216ra177, 2013
    • (2013) Sci Transl Med , vol.5
    • Yasuda, H.1    Park, E.2    Yun, C.H.3
  • 56
    • 85017619449 scopus 로고    scopus 로고
    • Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models
    • Gonzalvez F, Zhu X, Huang W-S, et al: Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models. Cancer Res 76:2644, 2016
    • (2016) Cancer Res , vol.76 , pp. 2644
    • Gonzalvez, F.1    Zhu, X.2    Huang, W.-S.3
  • 57
    • 85077483330 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network: NCCN guidelines, colon cancer, version 2.2017. https://www.nccn.org
  • 58
    • 85077481969 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network:NCCNguidelines, rectal cancer, version 3.2017. https://www.nccn.org
  • 59
    • 85077485168 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network: NCCN guidelines, non-small cell lung cancer, version 5.2017. https:// www.nccn.org
  • 60
    • 85077486707 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network: NCCN guidelines, soft tissue sarcoma, version 2.2017. https://www. nccn.org
  • 61
    • 84928739294 scopus 로고    scopus 로고
    • AZD9291 in EGFRinhibitor-resistant non-small-cell lung cancer
    • Jänne PA, Yang JC, KimDW, et al: AZD9291 in EGFRinhibitor-resistant non-small-cell lung cancer.NEngl JMed 372:1689-1699, 2015
    • (2015) NEngl JMed , vol.372 , pp. 1689-1699
    • Jänne, P.A.1    Yang, J.C.2    Kim, D.W.3
  • 64
    • 84895779578 scopus 로고    scopus 로고
    • Drugging the p53 pathway: Understanding the route to clinical efficacy
    • [Erratum: Nat Rev Drug Discov 13:314, 2014]
    • Khoo KH, Verma CS, Lane DP: Drugging the p53 pathway: Understanding the route to clinical efficacy. Nat Rev Drug Discov 13:217-236, 2014 [Erratum: Nat Rev Drug Discov 13:314, 2014]
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 217-236
    • Khoo, K.H.1    Verma, C.S.2    Lane, D.P.3
  • 65
    • 84946053976 scopus 로고    scopus 로고
    • Impact of precision medicine in diverse cancers: A meta-analysis of phase II clinical trials
    • Schwaederle M, Zhao M, Lee JJ, et al: Impact of precision medicine in diverse cancers: A meta-analysis of phase II clinical trials. J Clin Oncol 33:3817-3825, 2015
    • (2015) J Clin Oncol , vol.33 , pp. 3817-3825
    • Schwaederle, M.1    Zhao, M.2    Lee, J.J.3
  • 66
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature 490:61-70, 2012
    • (2012) Nature , vol.490 , pp. 61-70
  • 67
    • 84943613527 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of invasive lobular breast cancer
    • Ciriello G, Gatza ML, Beck AH, et al: Comprehensive molecular portraits of invasive lobular breast cancer. Cell 163: 506-519, 2015
    • (2015) Cell , vol.163 , pp. 506-519
    • Ciriello, G.1    Gatza, M.L.2    Beck, A.H.3
  • 68
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330-337, 2012
    • (2012) Nature , vol.487 , pp. 330-337
  • 69
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research Network: Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513:202-209, 2014
    • (2014) Nature , vol.513 , pp. 202-209
  • 70
    • 84959319260 scopus 로고    scopus 로고
    • Current advances in targeted therapies for metastatic gastric cancer: Improving patient care
    • Aguiar PN Jr, Muniz TP, Miranda RR, et al: Current advances in targeted therapies for metastatic gastric cancer: Improving patient care. Future Oncol 12:839-854, 2016
    • (2016) Future Oncol , vol.12 , pp. 839-854
    • Aguiar, P.N.1    Muniz, T.P.2    Miranda, R.R.3
  • 71
    • 77952243926 scopus 로고    scopus 로고
    • Evolving treatment of advanced colorectal cancer
    • Cercek A, Saltz L: Evolving treatment of advanced colorectal cancer. Curr Oncol Rep 12:153-159, 2010
    • (2010) Curr Oncol Rep , vol.12 , pp. 153-159
    • Cercek, A.1    Saltz, L.2
  • 72
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, et al: Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344:1038-1042, 2001
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 73
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037, 2001
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 74
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris MG, Johnson BE, Berry LD, et al: Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 311:1998-2006, 2014
    • (2014) JAMA , vol.311 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3
  • 75
    • 84907912530 scopus 로고    scopus 로고
    • Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: Validation and landmark analyses
    • Tsimberidou AM, Wen S, Hong DS, et al: Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: Validation and landmark analyses. Clin Cancer Res 20:4827-4836, 2014
    • (2014) Clin Cancer Res , vol.20 , pp. 4827-4836
    • Tsimberidou, A.M.1    Wen, S.2    Hong, D.S.3
  • 76
    • 85077486628 scopus 로고    scopus 로고
    • Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10, 000 patients
    • (in press)
    • Zehir A, Benayed R, Ronak H, et al: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10, 000 patients. Nature Med (in press)
    • Nature Med
    • Zehir, A.1    Benayed, R.2    Ronak, H.3
  • 77
    • 84902583099 scopus 로고    scopus 로고
    • Physicians' attitudes about multiplex tumor genomic testing
    • Gray SW, Hicks-Courant K, Cronin A, et al: Physicians' attitudes about multiplex tumor genomic testing. J Clin Oncol 32:1317-1323, 2014
    • (2014) J Clin Oncol , vol.32 , pp. 1317-1323
    • Gray, S.W.1    Hicks-Courant, K.2    Cronin, A.3
  • 78
    • 84899476119 scopus 로고    scopus 로고
    • Guidelines for investigating causality of sequence variants in human disease
    • MacArthur DG, Manolio TA, Dimmock DP, et al: Guidelines for investigating causality of sequence variants in human disease. Nature 508:469-476, 2014
    • (2014) Nature , vol.508 , pp. 469-476
    • MacArthur, D.G.1    Manolio, T.A.2    Dimmock, D.P.3
  • 79
    • 84928209346 scopus 로고    scopus 로고
    • Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
    • Richards S, Aziz N, Bale S, et al: Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17:405-424, 2015
    • (2015) Genet Med , vol.17 , pp. 405-424
    • Richards, S.1    Aziz, N.2    Bale, S.3
  • 80
    • 83755225553 scopus 로고    scopus 로고
    • NCCNtask force report: Evaluating the clinical utility of tumor markers in oncology
    • quiz S33
    • Febbo PG, Ladanyi M, Aldape KD, et al:NCCNtask force report: Evaluating the clinical utility of tumor markers in oncology. J Natl Compr Canc Netw 9:S1-S32, 2011 (suppl 5); quiz S33
    • (2011) J Natl Compr Canc Netw , vol.9 , pp. S1-S32
    • Febbo, P.G.1    Ladanyi, M.2    Aldape, K.D.3
  • 81
    • 10244261646 scopus 로고    scopus 로고
    • Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
    • Hayes DF, Bast RC, Desch CE, et al: Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 88:1456-1466, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1456-1466
    • Hayes, D.F.1    Bast, R.C.2    Desch, C.E.3
  • 82
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF: Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 101:1446-1452, 2009
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 83
    • 84875983431 scopus 로고    scopus 로고
    • Prevalence of off-label use and spending in 2010 among patentprotected chemotherapies in a population-based cohort of medical oncologists
    • Conti RM, Bernstein AC, Villaflor VM, et al: Prevalence of off-label use and spending in 2010 among patentprotected chemotherapies in a population-based cohort of medical oncologists. J Clin Oncol 31:1134-1139, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 1134-1139
    • Conti, R.M.1    Bernstein, A.C.2    Villaflor, V.M.3
  • 84
    • 77958522765 scopus 로고    scopus 로고
    • Regulatory actions on the off-label use of prescription drugs: Ongoing controversy and contradiction in 2009 and 2010
    • Fairman KA, Curtiss FR: Regulatory actions on the off-label use of prescription drugs: Ongoing controversy and contradiction in 2009 and 2010. J Manag Care Pharm 16:629-639, 2010
    • (2010) J Manag Care Pharm , vol.16 , pp. 629-639
    • Fairman, K.A.1    Curtiss, F.R.2
  • 85
    • 70350510661 scopus 로고    scopus 로고
    • Going off-label without venturing off-course: Evidence and ethical off-label prescribing
    • Largent EA, Miller FG, Pearson SD: Going off-label without venturing off-course: Evidence and ethical off-label prescribing. Arch Intern Med 169:1745-1747, 2009
    • (2009) Arch Intern Med , vol.169 , pp. 1745-1747
    • Largent, E.A.1    Miller, F.G.2    Pearson, S.D.3
  • 86
    • 84951745408 scopus 로고    scopus 로고
    • Combined BRAF andMEKinhibition with dabrafenib and trametinib in BRAF V600-mutant colorectal cancer
    • Corcoran RB, Atreya CE, Falchook GS, et al: Combined BRAF andMEKinhibition with dabrafenib and trametinib in BRAF V600-mutant colorectal cancer. J Clin Oncol 33:4023-4031, 2015
    • (2015) J Clin Oncol , vol.33 , pp. 4023-4031
    • Corcoran, R.B.1    Atreya, C.E.2    Falchook, G.S.3
  • 87
    • 2142762457 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of advanced non-small-cell lung cancer: Is there a role? Focus on Eastern Cooperative Oncology Group study 2598
    • Langer CJ, Stephenson P, Thor A, et al: Trastuzumab in the treatment of advanced non-small-cell lung cancer: Is there a role? Focus on Eastern Cooperative Oncology Group study 2598. J Clin Oncol 22:1180-1187, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1180-1187
    • Langer, C.J.1    Stephenson, P.2    Thor, A.3
  • 88
    • 85020264202 scopus 로고    scopus 로고
    • Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies
    • [epub ahead of print on March 23, 2017]
    • Jordan EJ, Kim HR, Arcila ME, et al: Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies. Cancer Disc doi: 10.1158/2159-8290. CD-16-1337 [epub ahead of print on March 23, 2017]
    • Cancer Disc
    • Jordan, E.J.1    Kim, H.R.2    Arcila, M.E.3
  • 89
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SH, et al: ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 30:863-870, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 90
    • 84859794344 scopus 로고    scopus 로고
    • ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway
    • Ou SH, Tan J, Yen Y, et al: ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway. Expert Rev Anticancer Ther 12:447-456, 2012
    • (2012) Expert Rev Anticancer Ther , vol.12 , pp. 447-456
    • Ou, S.H.1    Tan, J.2    Yen, Y.3
  • 91
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-1203, 2007
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 92
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
    • Jänne PA, Shaw AT, Pereira JR, et al: Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol 14:38-47, 2013
    • (2013) Lancet Oncol , vol.14 , pp. 38-47
    • Jänne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 93
    • 84961801697 scopus 로고    scopus 로고
    • Study design and rationale for a Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of Selumetinib in Combination With Docetaxel as Second-Line Treatment in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer (SELECT-1)
    • Jänne PA, Mann H, Ghiorghiu D: Study design and rationale for a Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of Selumetinib in Combination With Docetaxel as Second-Line Treatment in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer (SELECT-1). Clin Lung Cancer 17:e1-e4, 2016
    • (2016) Clin Lung Cancer , vol.17 , pp. e1-e4
    • Jänne, P.A.1    Mann, H.2    Ghiorghiu, D.3
  • 94
    • 84864340896 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial
    • Infante JR, Fecher LA, Falchook GS, et al: Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial. Lancet Oncol 13:773-781, 2012
    • (2012) Lancet Oncol , vol.13 , pp. 773-781
    • Infante, J.R.1    Fecher, L.A.2    Falchook, G.S.3
  • 95
    • 14844285975 scopus 로고    scopus 로고
    • Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
    • Rinehart J, Adjei AA, Lorusso PM, et al: Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 22:4456-4462, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 4456-4462
    • Rinehart, J.1    Adjei, A.A.2    Lorusso, P.M.3
  • 96
    • 84925262623 scopus 로고    scopus 로고
    • Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma
    • Hu-Lieskovan S, Mok S, Homet Moreno B, et al: Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med 7:279ra41, 2015
    • (2015) Sci Transl Med , vol.7
    • Hu-Lieskovan, S.1    Mok, S.2    Homet Moreno, B.3
  • 97
    • 84937629331 scopus 로고    scopus 로고
    • PD-L1 expression and tumor-infiltrating lymphocytes define different subsets of MAPK inhibitor-treated melanoma patients
    • Kakavand H, Wilmott JS, Menzies AM, et al: PD-L1 expression and tumor-infiltrating lymphocytes define different subsets of MAPK inhibitor-treated melanoma patients. Clin Cancer Res 21:3140-3148, 2015
    • (2015) Clin Cancer Res , vol.21 , pp. 3140-3148
    • Kakavand, H.1    Wilmott, J.S.2    Menzies, A.M.3
  • 98
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le DT, Uram JN, Wang H, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372: 2509-2520, 2015
    • (2015) N Engl J Med , vol.372 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 99
    • 84962301039 scopus 로고    scopus 로고
    • RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: Therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors
    • Loi S, Dushyanthen S, Beavis PA, et al: RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: Therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors. Clin Cancer Res 22:1499-1509, 2016
    • (2016) Clin Cancer Res , vol.22 , pp. 1499-1509
    • Loi, S.1    Dushyanthen, S.2    Beavis, P.A.3
  • 100
    • 77951658161 scopus 로고    scopus 로고
    • KRASmutant lung cancer cells are differentially responsive toMEKinhibitor due to AKT or STAT3 activation: Implication for combinatorial approach
    • Yoon YK, Kim HP, Han SW, et al: KRASmutant lung cancer cells are differentially responsive toMEKinhibitor due to AKT or STAT3 activation: Implication for combinatorial approach. Mol Carcinog 49:353-362, 2010
    • (2010) Mol Carcinog , vol.49 , pp. 353-362
    • Yoon, Y.K.1    Kim, H.P.2    Han, S.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.